Abstract:
:A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lipid monolayer, and combine the advantages and avoid disadvantages of polymeric nanoparticles and liposomes in drug delivery. X-ray photoelectron spectroscopy (XPS) confirmed the coating of the mixed lipid monolayer on the polymeric core. Fluorescent microscopy proved the targeting efficacy of the folic acid conjugated on the mixed lipid monolayer for the cancer cells of over expression of folate receptors. The folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core were proved to possess sustainable, controlled and targeted delivery of anticancer drugs with Docetaxel as a model drug, which may provide a drug delivery system of precise control of the targeting effect.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Liu Y,Li K,Pan J,Liu B,Feng SSdoi
10.1016/j.biomaterials.2009.09.036subject
Has Abstractpub_date
2010-01-01 00:00:00pages
330-8issue
2eissn
0142-9612issn
1878-5905pii
S0142-9612(09)00966-1journal_volume
31pub_type
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