The role of sterilization in the cytocompatibility of titania nanotubes.

abstract：:The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential cytotoxicity of these particles remains an issue of debate. In the present study, 4 different NP types (dextran-coated Endorem, carboxydextran-coated Resovist, lipid-coated...

journal_title：Biomaterials

authors： Soenen SJ,Himmelreich U,Nuytten N,De Cuyper M

更新日期：2011-01-01 00:00:00

abstract：:We present a new ultrasonic technique for monitoring the entire setting process of injectable bone cement. The problem with existing standards is their subjectivity. Because of this the results are not comparable between different research groups. A strong advantage with the proposed technique is that it is non-invasi...

journal_title：Biomaterials

authors： Carlson J,Nilsson M,Fernández E,Planell JA

更新日期：2003-01-01 00:00:00

abstract：:Mesenchymal condensation is a pre-requisite of chondrogenesis during embryonic development. The current understanding of chondrogenesis is limited in terms of chondrogenic condensation mechanisms. In particular, the role of matrix stiffness on homotypic cell-cell interactions leading to the establishment of distinct a...

journal_title：Biomaterials

authors： Ghosh S,Laha M,Mondal S,Sengupta S,Kaplan DL

更新日期：2009-11-01 00:00:00

abstract：:The in vitro response in simulated body fluid (SBF) of silicate glass coatings on Ti6A14V was evaluated. Glasses belonging to the SiO2-CaO-MgO-Na2O-K2O-P2O5 system were used to prepare 50-70 m thick coatings on Ti6Al4V, employing a simple enameling technique. Glasses with silica content higher than 55 wt% can be used ...

journal_title：Biomaterials

authors： Saiz E,Goldman M,Gomez-Vega JM,Tomsia AP,Marshall GW,Marshall SJ

更新日期：2002-09-01 00:00:00

abstract：:We design a class of water-dispersible hybrid nanogels for intracellular delivery of hydrophobic curcumin. The core-shell structured hybrid nanogels were synthesized by coating the Ag/Au bimetallic nanoparticles (NPs) with a hydrophobic polystyrene (PS) gel layer as inner shell, and a subsequent thin hydrophilic nonli...

journal_title：Biomaterials

authors： Wu W,Shen J,Banerjee P,Zhou S

更新日期：2011-01-01 00:00:00

abstract：:Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) were studied by computer graphics with a personal computer. Crystal models of fluoridated hydroxyapatite and fluorapatite, in which F- ions are substituted into some or all OH- positions, were also drawn. Data on the structural coordinates of the hydroxyapatite a...

journal_title：Biomaterials

authors： Okazaki M,Sato M

更新日期：1990-10-01 00:00:00

abstract：:Glioblastoma (GBM) is the deadliest and most common type of primary brain tumor in adults with a grim prognosis despite multimodal treatments. Dendritic cell (DC)-based immunotherapy has emerged as a promising therapeutic modality for GBM, whose efficacy is nonetheless fundamentally undermined by GBM-induced immunosup...

journal_title：Biomaterials

authors： Li TF,Li K,Zhang Q,Wang C,Yue Y,Chen Z,Yuan SJ,Liu X,Wen Y,Han M,Komatsu N,Xu YH,Zhao L,Chen X

更新日期：2018-10-01 00:00:00

abstract：:A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lip...

journal_title：Biomaterials

authors： Liu Y,Li K,Pan J,Liu B,Feng SS

更新日期：2010-01-01 00:00:00

abstract：:Three-dimensional constructs formed by cells embedded in an exogenous scaffold could not represent a faithful in vitro replica of native and functional tissues. In this work we produced an endogenous human skin equivalent by means of a tissue engineering process that induces the full morphogenesis of functional dermal...

journal_title：Biomaterials

authors： Casale C,Imparato G,Urciuolo F,Netti PA

更新日期：2016-09-01 00:00:00

abstract：:The efficient delivery of short interfering RNA (siRNA) is an enormous challenge in the field of gene therapy. Herein, we report a delivery nanosystem based on programmed DNA self-assembly mammalian target of rapamycin (mTOR) siRNA-loaded DNA nanotubes (DNA-NTs). We demonstrate that these siRNA-DNA-NTs can be effectiv...

journal_title：Biomaterials

authors： You Z,Qian H,Wang C,He B,Yan J,Mao C,Wang G

更新日期：2015-10-01 00:00:00

abstract：:The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable ...

journal_title：Biomaterials

authors： Wang H,Shi J,Wang Y,Yin Y,Wang L,Liu J,Liu Z,Duan C,Zhu P,Wang C

更新日期：2014-04-01 00:00:00

abstract：:Tissue engineering combined with gene therapy represents a promising approach for bone regeneration. The Hypoxia-inducible factor-1α (HIF-1α) gene is a pivotal regulator of vascular reactivity and angiogenesis. Our recent study has showed that HIF-1α could promote osteogenesis of bone mesenchymal stem cells (BMSCs) us...

journal_title：Biomaterials

authors： Zou D,Zhang Z,He J,Zhu S,Wang S,Zhang W,Zhou J,Xu Y,Huang Y,Wang Y,Han W,Zhou Y,Wang S,You S,Jiang X,Huang Y

更新日期：2011-12-01 00:00:00

abstract：:Cationic polymers are currently being studied as non-viral vectors to deliver therapeutic DNA into cells. In this study, a series of trehalose-based glycopolymers containing four secondary amines in the repeat unit were synthesized via the 'click reaction' [degrees of polymerization (n(w))=35, 53, 75, or 100] to eluci...

journal_title：Biomaterials

authors： Srinivasachari S,Liu Y,Prevette LE,Reineke TM

更新日期：2007-06-01 00:00:00

abstract：:The development of more selective delivery systems for cancer diagnosis and chemotherapy is one of the most important goals of current anticancer research. The purpose of this study is to evaluate various self-assembled nanoparticles as candidates to shuttle radionuclide and/or drugs into tumors and to investigate the...

journal_title：Biomaterials

authors： Cho YW,Park SA,Han TH,Son DH,Park JS,Oh SJ,Moon DH,Cho KJ,Ahn CH,Byun Y,Kim IS,Kwon IC,Kim SY

更新日期：2007-02-01 00:00:00

abstract：:Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to engineer human cartilage grafts in a size with clinical relevance f...

journal_title：Biomaterials

authors： Santoro R,Olivares AL,Brans G,Wirz D,Longinotti C,Lacroix D,Martin I,Wendt D

更新日期：2010-12-01 00:00:00

abstract：:A 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) was exploited as a ligand for efficient brain-targeting gene delivery. RVG29 was modified on polyamidoamine dendrimers (PAMAM) through bifunctional PEG, then complexed with DNA, yielding PAMAM-PEG-RVG29/DNA nanoparticles (NPs). The NPs were obs...

journal_title：Biomaterials

authors： Liu Y,Huang R,Han L,Ke W,Shao K,Ye L,Lou J,Jiang C

更新日期：2009-09-01 00:00:00

abstract：:FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands I, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the...

journal_title：Biomaterials

authors： Chang MC,Tanaka J

更新日期：2002-12-01 00:00:00

abstract：:The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodiu...

journal_title：Biomaterials

authors： Repka MA,McGinity JW

更新日期：2000-07-01 00:00:00

abstract：:Periosteal derived bovine osteoblast-like cells migrated in culture onto an ionomeric cement. Cell cultures were maintained for 4 weeks and used to study the in vitro behaviour of cells on the ionomeric bone cement (IC). The cells produced bone matrix proteins (osteocalcin, bone sialoprotein II) and were osteoblast-li...

journal_title：Biomaterials

authors： Meyer U,Szulczewski DH,Barckhaus RH,Atkinson M,Jones DB

更新日期：1993-10-01 00:00:00

abstract：:In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al(2)O(3)) or 'ultra-high molecular weight polyethylene' (UHMWPE) particles for 24h. T...

journal_title：Biomaterials

authors： Granchi D,Amato I,Battistelli L,Ciapetti G,Pagani S,Avnet S,Baldini N,Giunti A

更新日期：2005-05-01 00:00:00

abstract：:Hepatocytes are anchorage-dependent cells sensitive to microenvironment; the control of the physicochemical properties of the extra-cellular matrices may be useful to the maintenance of hepatocyte functions in vitro for various applications. In a microcapsule-based 3-D hepatocyte culture microenvironment, we could con...

journal_title：Biomaterials

authors： Ng S,Wu YN,Zhou Y,Toh YE,Ho ZZ,Chia SM,Zhu JH,Mao HQ,Yu H

更新日期：2005-06-01 00:00:00

abstract：:There is a growing demand for the production of a DNA biosensor with applications in medicine, the food industry, agriculture, veterinary science and environmental science. In this paper we describe methods for the optical and electrochemical detection of DNA using the enzyme horseradish peroxidase (EC 1.11.1.7) and g...

journal_title：Biomaterials

authors： Downs ME,Warner PJ,Turner AP,Fothergill JC

更新日期：1988-01-01 00:00:00

abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

journal_title：Biomaterials

authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

更新日期：2020-02-01 00:00:00

abstract：:Drug hepatotoxicity testing requires in vitro hepatocyte culture to maintain the long-term and stable liver specific functions. We developed a drug testing platform based on laminar-flow immediate-overlay hepatocyte sandwich perfusion culture. The immediate-overlay sandwich (collagen-coated porous polymeric membrane a...

journal_title：Biomaterials

authors： Xia L,Ng S,Han R,Tuo X,Xiao G,Leo HL,Cheng T,Yu H

更新日期：2009-10-01 00:00:00

abstract：:Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including food uptake, eye movements and facial expressions. Although craniofacial muscles have significantly different embryonic origin, most current skeletal muscle differentiation protocols using human induced plurip...

journal_title：Biomaterials

authors： Kim E,Wu F,Wu X,Choo HJ

更新日期：2020-07-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:RNA interference induced by double-stranded, small interfering RNA (siRNA) molecules has attracted great attention as a genetic therapeutic approach. Despite major advances in this field, new nanoparticle formulations are required for in vivo delivery of siRNA, particularly for tissue-specific delivery of siRNA reagen...

journal_title：Biomaterials

authors： Tagalakis AD,He L,Saraiva L,Gustafsson KT,Hart SL

更新日期：2011-09-01 00:00:00

abstract：:Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...

journal_title：Biomaterials

authors： Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

更新日期：2012-03-01 00:00:00

abstract：:A nucleus pulposus prosthesis (NPP) made of the hydrogel N-vinyl-2-pyrrolidinone copolymerized with 2-(4'-iodobenzoyl)-oxo-ethyl methacrylate has recently been developed. The special features of this NPP, i.e. intrinsic radiopacity and its ability to swell in situ to fill the nucleus cavity and restore disc height, we...

journal_title：Biomaterials

authors： Bergknut N,Smolders LA,Koole LH,Voorhout G,Hagman RE,Lagerstedt AS,Saralidze K,Hazewinkel HA,van der Veen AJ,Meij BP

更新日期：2010-09-01 00:00:00

abstract：:Tissue engineering scaffolds with complex geometries can provide an architecture that directs tissue formation. Drug delivery from these scaffolds to promote regeneration is often challenging due to the complex fabrication processes. Surface-mediated DNA delivery from multiple channel bridges was applied to deliver li...

journal_title：Biomaterials

authors： De Laporte L,Yan AL,Shea LD

更新日期：2009-04-01 00:00:00