In vitro model of mesenchymal condensation during chondrogenic development.

abstract：:Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...

journal_title：Biomaterials

authors： Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

更新日期：2012-12-01 00:00:00

abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

journal_title：Biomaterials

authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

更新日期：2012-10-01 00:00:00

abstract：:Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

journal_title：Biomaterials

authors： Chen TY,Wen TK,Dai NT,Hsu SH

更新日期：2020-12-16 00:00:00

abstract：UNLABELLED:Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir fo...

journal_title：Biomaterials

authors： Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

更新日期：2016-03-01 00:00:00

abstract：:We have synthesized and characterized a novel peptide fluorosurfactant polymer (PFSP) modification that facilitates the adhesion and growth of endothelial cells on expanded polytetrafluoroetheylene (ePTFE) vascular graft material. This PFSP consists of a poly(vinyl amine) (PVAm) backbone with integrin binding Arg-Gly-...

journal_title：Biomaterials

authors： Larsen CC,Kligman F,Kottke-Marchant K,Marchant RE

更新日期：2006-10-01 00:00:00

abstract：:Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their th...

journal_title：Biomaterials

authors： Lu M,Huang Y

更新日期：2020-03-02 00:00:00

abstract：:Renal regeneration approaches offer great potential for the treatment of chronic kidney disease, but their availability remains limited by the clinical challenges they pose. In the present study, we used continuous detergent perfusion to generate decellularized (DC) rat kidney scaffolds. The scaffolds retained intact ...

journal_title：Biomaterials

authors： Yu YL,Shao YK,Ding YQ,Lin KZ,Chen B,Zhang HZ,Zhao LN,Wang ZB,Zhang JS,Tang ML,Mei J

更新日期：2014-08-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:Recent advances in biomaterial surface engineering have shown that surface biomechanical, spatial and topographical properties can elicit control over fundamental biological processes such as cell shape, proliferation, differentiation and apoptosis. Along these lines, we have very recently shown that the self-assembly...

journal_title：Biomaterials

authors： George PA,Quinn K,Cooper-White JJ

更新日期：2010-02-01 00:00:00

abstract：:A pH-sensitive molecularly imprinted polymer (MIP) nanospheres/hydrogel composite exhibiting controlled release of dexamethasone-21 phosphate disodium (DXP) was developed as a potential coating for implantable biosensors to improve their biocompatibility. The molecularly imprinted pH-sensitive nanospheres were prepare...

journal_title：Biomaterials

authors： Wang C,Javadi A,Ghaffari M,Gong S

更新日期：2010-06-01 00:00:00

abstract：:Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, includin...

journal_title：Biomaterials

authors： Choi BH,Choi YS,Kang DG,Kim BJ,Song YH,Cha HJ

更新日期：2010-12-01 00:00:00

abstract：:Novel cationic pentablock copolymers with poly(diethylamino ethyl methacrylate) blocks covalently attached to parent triblock Pluronic copolymers have been designed and developed as sustained release non-viral gene delivery vectors. These copolymers electrostatically condense plasmid DNA into nanostructures (nanoplexe...

journal_title：Biomaterials

authors： Agarwal A,Unfer RC,Mallapragada SK

更新日期：2008-02-01 00:00:00

abstract：:We investigated the morphological effect of phase-separated block copolymer surfaces composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) and poly(dimethylsiloxane) (PDMS) on protein adsorption and cell adhesion behavior. We observed three different types of phase-separated surface morphologies by T...

journal_title：Biomaterials

authors： Seo JH,Matsuno R,Takai M,Ishihara K

更新日期：2009-10-01 00:00:00

abstract：:Superparamagnetic magnetite nanoparticles (MNP) coated with silica were synthesized and chronically implanted into the middle ear epithelial tissues of a guinea pig model (n=16) for the generation of force by an external magnetic field. In vivo limitations of biocompatibility include particle morphology, size distribu...

journal_title：Biomaterials

authors： Dormer K,Seeney C,Lewelling K,Lian G,Gibson D,Johnson M

更新日期：2005-05-01 00:00:00

abstract：:Three types of bioactive polymethylmethacrylate (PMMA)-based bone cement containing nano-sized titania (TiO2) particles were prepared, and their mechanical properties and osteoconductivity are evaluated. The three types of bioactive bone cement were T50c, ST50c, and ST60c, which contained 50 wt% TiO2, and 50 and 60 wt...

journal_title：Biomaterials

authors： Goto K,Tamura J,Shinzato S,Fujibayashi S,Hashimoto M,Kawashita M,Kokubo T,Nakamura T

更新日期：2005-11-01 00:00:00

abstract：:Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our limited understanding and control of the interactions within complex in...

journal_title：Biomaterials

authors： D'Hollander A,Jans H,Velde GV,Verstraete C,Massa S,Devoogdt N,Stakenborg T,Muyldermans S,Lagae L,Himmelreich U

更新日期：2017-04-01 00:00:00

abstract：:Hepatocytes are anchorage-dependent cells sensitive to microenvironment; the control of the physicochemical properties of the extra-cellular matrices may be useful to the maintenance of hepatocyte functions in vitro for various applications. In a microcapsule-based 3-D hepatocyte culture microenvironment, we could con...

journal_title：Biomaterials

authors： Ng S,Wu YN,Zhou Y,Toh YE,Ho ZZ,Chia SM,Zhu JH,Mao HQ,Yu H

更新日期：2005-06-01 00:00:00

abstract：:Calcium phosphate coatings were deposited by pulsed laser ablation with a radiation of 355 nm from a Nd:YAG laser. All the coatings were obtained at the same conditions, but deposition was stopped after different number of pulses to get coatings with different thickness. The influence of thickness in the structural an...

journal_title：Biomaterials

authors： Fernández-Pradas JM,Clèries L,Sardin G,Morenza JL

更新日期：2002-05-01 00:00:00

abstract：:The nanoscale materials properties of bone apatite crystals have been implicated in breast cancer bone metastasis and their interactions with extracellular matrix proteins are likely involved. In this study, we used geologic hydroxyapatite (HAP, Ca10(PO4)6(OH)2), closely related to bone apatite, to investigate how HAP...

journal_title：Biomaterials

authors： Wu F,Chen W,Gillis B,Fischbach C,Estroff LA,Gourdon D

更新日期：2017-02-01 00:00:00

abstract：:The rationale behind this work is to design an implant device, based on a ferromagnetic material, with the potential to deform in vivo promoting osseointegration through the growth of a healthy periprosthetic bone structure. One of the primary requirements for such a device is that the material should be non-inflammat...

journal_title：Biomaterials

authors： Malheiro VN,Spear RL,Brooks RA,Markaki AE

更新日期：2011-10-01 00:00:00

abstract：:Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of topical ...

journal_title：Biomaterials

authors： Lin YH,Tsai SC,Lai CH,Lee CH,He ZS,Tseng GC

更新日期：2013-06-01 00:00:00

abstract：:Chemotherapeutic agents often cause severe side effects because they produce a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both tumor microenvironment-sensitive polypeptides (TMSP) and folate to create a more selecti...

journal_title：Biomaterials

authors： Gao W,Xiang B,Meng TT,Liu F,Qi XR

更新日期：2013-05-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fa...

journal_title：Biomaterials

authors： Li J,Darabi M,Gu J,Shi J,Xue J,Huang L,Liu Y,Zhang L,Liu N,Zhong W,Zhang L,Xing M,Zhang L

更新日期：2016-09-01 00:00:00

abstract：:The production profile of interleukin 1 (IL-1) from mouse peritoneal macrophages (M phi) was determined following their incubation with poly(DL-lactic acid) (PDLLA) granules containing ovalbumin (OVA). Upon incubation, M phi produced IL-1 at a significantly high rate compared with those incubated with OVA in the free ...

journal_title：Biomaterials

authors： Nakaoka R,Tabata Y,Ikada Y

更新日期：1996-12-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of the c-Myc oncogene in iPSCs affected hepatic differentiation or inhibited in vivo tumor formation. In this study, we demon...

journal_title：Biomaterials

authors： Li HY,Chien Y,Chen YJ,Chen SF,Chang YL,Chiang CH,Jeng SY,Chang CM,Wang ML,Chen LK,Hung SI,Huo TI,Lee SD,Chiou SH

更新日期：2011-09-01 00:00:00

abstract：:A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, an...

journal_title：Biomaterials

authors： Ye X,Lu L,Kolewe ME,Park H,Larson BL,Kim ES,Freed LE

更新日期：2013-12-01 00:00:00

abstract：:Delivery of polynucleotide-based therapeutics into target cells involves interactions with glycosaminoglycan chains that are located on cell membrane milieu. Mechanisms governing glycosaminoglycan-mediated changes in the nanoparticulate structures of polymer-polynucleotide complexes are unknown, and cannot be fully el...

journal_title：Biomaterials

authors： Meneksedag-Erol D,Tang T,Uludağ H

更新日期：2018-02-01 00:00:00

abstract：:Composite particles made by growing nanoscopic silicon wires from the surface of monodispersed, microsized silica beads were tested in this study for their ability to affect the integrity and permeability of an epithelial cell layer. Polyethylene glycol (PEG) is known to sterically stabilize particles and prevent prot...

journal_title：Biomaterials

authors： Uskoković V,Lee PP,Walsh LA,Fischer KE,Desai TA

更新日期：2012-02-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder currently having no cure. Here we report that culture substrates patterned with nanogrooves and functionalized with Matrigel (or laminin) present an engineered cell microenvironment to allow myotubes derived from non-diseased, less-affected DMD, and severel...

journal_title：Biomaterials

authors： Xu B,Magli A,Anugrah Y,Koester SJ,Perlingeiro RCR,Shen W

更新日期：2018-11-01 00:00:00

abstract：:We studied non-implanted ultra-high molecular weight polyethylene (UHMWPE) knee components, that were gamma-sterilized in air and shelf-aged during 6 and 7 years, to explore fracture mechanisms in the degraded material. Prior to the fractography study, we assessed degradation through FTIR and optical density measureme...

journal_title：Biomaterials

authors： Puértolas JA,Larrea A,Gómez-Barrena E

更新日期：2001-08-01 00:00:00