当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > The effect of RGD fluorosurfactant polymer modification of ePTFE on endothelial cell adhesion, growth, and function.

The effect of RGD fluorosurfactant polymer modification of ePTFE on endothelial cell adhesion, growth, and function.

Abstract：

:We have synthesized and characterized a novel peptide fluorosurfactant polymer (PFSP) modification that facilitates the adhesion and growth of endothelial cells on expanded polytetrafluoroetheylene (ePTFE) vascular graft material. This PFSP consists of a poly(vinyl amine) (PVAm) backbone with integrin binding Arg-Gly-Asp (RGD) peptides and perfluorocarbon pendant branches for adsorption and stable adhesion to underlying ePTFE. Aqueous PFSP solution was used to modify the surface of fluorocarbon substrates. Following subconfluent seeding, endothelial cell (EC) adhesion and growth on PFSP was assessed by determining cell population at different time points. Spectroscopic results indicated successful synthesis of PFSP. PFSP modification of ePTFE reduced the receding water contact angle measurement from 120 degrees to 6 degrees , indicating successful surface modification. Quantification of cell population demonstrated reduced EC attachment efficiency but increased growth rate on RGD PFSP compared with fibronectin (FN). Actin staining revealed a well-developed cytoskeleton for ECs on RGD PFSP indicative of stable adhesion. Uptake of acetylated low-density lipoprotein and positive staining for VE-Cadherin confirm EC phenotype for adherent cells. Production of prostacyclin, a potent antiplatelet agent, was equivalent between ECs on FN and RGD PFSP surfaces. Our results indicate successful synthesis and surface modification with PFSP; this is a simple, quantitative, and effective approach to modifying ePTFE to encourage endothelial cell attachment, growth, and function.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Larsen CC,Kligman F,Kottke-Marchant K,Marchant RE

doi

10.1016/j.biomaterials.2006.05.009

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

4846-55

issue

28

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(06)00448-0

journal_volume

27

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and beta-TCP ceramics.

    abstract：:This study investigated the in vitro effects of akermanite, a new kind of Ca-, Mg-, Si-containing bioceramic, on the attachment, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs). Parallel comparison of the cellular behaviors of hASCs on the akermanite was made with those on beta...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.08.039

    authors： Liu Q,Cen L,Yin S,Chen L,Liu G,Chang J,Cui L

    更新日期：2008-12-01 00:00:00

  • Osteoblast response to PLGA tissue engineering scaffolds with PEO modified surface chemistries and demonstration of patterned cell response.

    abstract：:Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.09.064

    authors： Koegler WS,Griffith LG

    更新日期：2004-06-01 00:00:00

  • Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors.

    abstract：:Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.08.055

    authors： Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

    更新日期：2011-12-01 00:00:00

  • Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing.

    abstract：:Restoration of tissue integrity and tissue function of wounded skin are both essential for wound repair and regeneration, while synergistic promotion of the two remains elusive. Since elevated reactive oxygen species (ROS) production in the injured site has been implicated in triggering a set of deleterious effects su...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.10.018

    authors： Wu H,Li F,Wang S,Lu J,Li J,Du Y,Sun X,Chen X,Gao J,Ling D

    更新日期：2018-01-01 00:00:00

  • Microbial adhesion to ionogenic PHEMA, PU and PP implants.

    abstract：:This study concentrates on adhesion of microorganisms to polymeric biomaterials implanted in the urinary tract. A number of extensively used polymeric biomaterials (i.e., poly(hydroxyethyl-methacrylate) and its copolymers with a series of acrylic monomers--acrylic acid and dimethylaminoethyl methacrylate--polyetherure...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)89662-1

    authors： Kiremitci-Gumusderelioglu M,Pesmen A

    更新日期：1996-02-01 00:00:00

  • Biocompatible, hyaluronic acid modified silicone elastomers.

    abstract：:Although silicones possess many useful properties as biomaterials, their hydrophobicity can be problematic. To a degree, this issue can be addressed by surface modification with hydrophilic polymers such as poly(ethylene glycol), but the resulting structures are usually not conducive to cell growth. In the present wor...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.01.069

    authors： Alauzun JG,Young S,D'Souza R,Liu L,Brook MA,Sheardown HD

    更新日期：2010-05-01 00:00:00

  • Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices.

    abstract：:Hepatocytes are anchorage-dependent cells sensitive to microenvironment; the control of the physicochemical properties of the extra-cellular matrices may be useful to the maintenance of hepatocyte functions in vitro for various applications. In a microcapsule-based 3-D hepatocyte culture microenvironment, we could con...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.08.017

    authors： Ng S,Wu YN,Zhou Y,Toh YE,Ho ZZ,Chia SM,Zhu JH,Mao HQ,Yu H

    更新日期：2005-06-01 00:00:00

  • A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria.

    abstract：:Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the important component in biofilm extracellular polymeric substances (EPS), extracellular DNA (eDNA) has been manifested to connect different EPS components and bacteria together, leading biofilms hard to eliminate. Herein a serie...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.04.007

    authors： Liu Z,Wang F,Ren J,Qu X

    更新日期：2019-07-01 00:00:00

  • Tissue responses of calcium phosphate cement: a study in dogs.

    abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00016-8

    authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

    更新日期：2000-06-01 00:00:00

  • The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching.

    abstract：:Vascular endothelial growth factor (VEGF) has been extensively investigated to promote vascularization at damaged or diseased sites and in tissue implants. Here we are interested in determining if the manner in which VEGF is presented from a scaffold to endothelial cells influences the architecture of the blood vessel...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.06.027

    authors： Anderson SM,Siegman SN,Segura T

    更新日期：2011-10-01 00:00:00

  • Bile acid transporter mediated endocytosis of oral bile acid conjugated nanocomplex.

    abstract：:The development of highly funtional and orally available nanoparticles is the ultimate goal in nanoparticle delivery. Various functional nanoparticles have been studied to that end but there has yet to be an oral nanoparticle that can be successfully applied. Here, we describe for the first time a novel bile acid conj...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.09.022

    authors： Park J,Choi JU,Kim K,Byun Y

    更新日期：2017-12-01 00:00:00

  • Alginate hydrogels as synthetic extracellular matrix materials.

    abstract：:Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(98)00107-0

    authors： Rowley JA,Madlambayan G,Mooney DJ

    更新日期：1999-01-01 00:00:00

  • Treating metastatic triple negative breast cancer with CD44/neuropilin dual molecular targets of multifunctional nanoparticles.

    abstract：:Metastasis of cancer makes up the vast majority of cancer-related deaths, and it usually initiates from tumor cells invasiveness and develops through tumor neovasculature. In this work, we have fabricated a CD44/neuropilin dual receptor-targeting nanoparticulate system (tLyP-1-HT NPs) with endogenous or FDA approved c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.05.022

    authors： Liang DS,Zhang WJ,Wang AT,Su HT,Zhong HJ,Qi XR

    更新日期：2017-08-01 00:00:00

  • Failure of Aβ(1-40) amyloid fibrils under tensile loading.

    abstract：:Amyloid fibrils and plaques are detected in the brain tissue of patients affected by Alzheimer's disease, but have also been found as part of normal physiological processes such as bacterial adhesion. Due to their highly organized structures, amyloid proteins have also been used for the development of nanomaterials, f...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.11.066

    authors： Paparcone R,Buehler MJ

    更新日期：2011-05-01 00:00:00

  • Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates.

    abstract：:Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms are unknown. In order to investigate the role of 3D cell-cell interactions in maintaining hepatocyte differentiated functions ex vivo, primary mouse hepatocytes were ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.11.063

    authors： Chang TT,Hughes-Fulford M

    更新日期：2014-02-01 00:00:00

  • Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering.

    abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.12.080

    authors： Tan H,Chu CR,Payne KA,Marra KG

    更新日期：2009-05-01 00:00:00

  • Microenvironment induced spheroid to sheeting transition of immortalized human keratinocytes (HaCaT) cultured in microbubbles formed in polydimethylsiloxane.

    abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.06.013

    authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

    更新日期：2011-10-01 00:00:00

  • A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.

    abstract：:Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.05.018

    authors： Song R,Zhang M,Liu Y,Cui Z,Zhang H,Tang Z,Chen X,Wu H,Yao Z,He M,Bu W

    更新日期：2018-08-01 00:00:00

  • Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth.

    abstract：:The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By ble...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.08.031

    authors： Ji J,Zhu H,Shen J

    更新日期：2004-05-01 00:00:00

  • The effect of poly(trimethylene carbonate) molecular weight on macrophage behavior and enzyme adsorption and conformation.

    abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.07.023

    authors： Vyner MC,Li A,Amsden BG

    更新日期：2014-11-01 00:00:00

  • New collagen implant as dural substitute.

    abstract：:A collagen prosthesis was developed as a dural substitute. It is composed of a Dallop matrix-polyester knitted net with radiation cross-linked collagen on both sides. Collagen was derived from enzyme-treated bovine Achilles tendons. Improved hydrophilic properties of the polyester base ensuring stronger adhesion to co...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(91)90041-8

    authors： Pietrucha K

    更新日期：1991-04-01 00:00:00

  • Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential.

    abstract：:Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) and poly(epsilon-caprolactone) (PCL) were obtained using met...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.10.007

    authors： Kwon IK,Kidoaki S,Matsuda T

    更新日期：2005-06-01 00:00:00

  • Water absorption characteristics of some unfilled resins.

    abstract：:The water absorption characteristics of resins, upon which many composite filling materials are based, have been studied. In general, the equilibrium uptake is less than that predicted from the water absorption of composite filling materials, if it is assumed that the polymer alone absorbs the water. Also, whereas the...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(86)90039-6

    authors： Braden M,Davy KW

    更新日期：1986-11-01 00:00:00

  • Re-assessing the enhanced permeability and retention effect in peripheral arterial disease using radiolabeled long circulating nanoparticles.

    abstract：:As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.05.018

    authors： England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

    更新日期：2016-09-01 00:00:00

  • Mucoadhesive liposomes for intranasal immunization with an avian influenza virus vaccine in chickens.

    abstract：:The aim of this study was to characterize a nasally delivered bioadhesive liposome using an inactivated H5N3 virus as a model antigen. Bioadhesive liposomes were developed using tremella (T) or xanthan gum (XG) as the bioadhesive polysaccharide. Using chickens as the target animal, we evaluated whether delivery of a b...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.06.046

    authors： Chiou CJ,Tseng LP,Deng MC,Jiang PR,Tasi SL,Chung TW,Huang YY,Liu DZ

    更新日期：2009-10-01 00:00:00

  • Mechanism of initial attachment of cells derived from human bone to commonly used prosthetic materials during cell culture.

    abstract：:The suitability of polymeric biomaterials as surfaces for the attachment and growth of cells has often been investigated in cell culture. In this study the contribution that serum fibronectin (Fn) or vitronectin (Vn) make to the attachment and spreading of cells cultured from explanted human bone (bone-derived cells) ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(94)90070-1

    authors： Howlett CR,Evans MD,Walsh WR,Johnson G,Steele JG

    更新日期：1994-02-01 00:00:00

  • Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM.

    abstract：:Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of culture conditions enabli...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.01.081

    authors： Ng CP,Sharif AR,Heath DE,Chow JW,Zhang CB,Chan-Park MB,Hammond PT,Chan JK,Griffith LG

    更新日期：2014-04-01 00:00:00

  • Tissue engineering scaffolds using superstructures.

    abstract：:Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fib...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)85753-x

    authors： Wintermantel E,Mayer J,Blum J,Eckert KL,Lüscher P,Mathey M

    更新日期：1996-01-01 00:00:00

  • Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.

    abstract：:In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that scaffolds that promote sequenti...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.10.017

    authors： Spiller KL,Nassiri S,Witherel CE,Anfang RR,Ng J,Nakazawa KR,Yu T,Vunjak-Novakovic G

    更新日期：2015-01-01 00:00:00

  • The influence of the restoration-tooth interface in light cured composite restorations: a finite element analysis.

    abstract：:This study examines the early shrinkage behaviour of dental composite resins, and in particular the interfacial stresses around the margins of a composite restoration. The development of stresses at the restoration-tooth interface can have a detrimental effect on the longevity of a restoration. The influence of this i...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00058-8

    authors： Ensaff H,O'Doherty DM,Jacobsen PH

    更新日期：2001-12-01 00:00:00