Abstract:
:A collagen prosthesis was developed as a dural substitute. It is composed of a Dallop matrix-polyester knitted net with radiation cross-linked collagen on both sides. Collagen was derived from enzyme-treated bovine Achilles tendons. Improved hydrophilic properties of the polyester base ensuring stronger adhesion to collagen were obtained by pretreating the net with a low-temperature plasma in air. Cross-linking of collagen and simultaneous sterilization of the final prosthesis was obtained by irradiation with 5 MeV electrons. Measurement of the physicochemical parameters of the prostheses gives satisfactory results. In vitro biological examinations show that the prostheses are non-toxic. The results of in vivo clinical experimental evaluation are positive and lead to the conclusion that the collagen-covered polyester net does not differ significantly from Zenoderm dural substitute.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Pietrucha Kdoi
10.1016/0142-9612(91)90041-8subject
Has Abstractpub_date
1991-04-01 00:00:00pages
320-3issue
3eissn
0142-9612issn
1878-5905pii
0142-9612(91)90041-8journal_volume
12pub_type
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