Bonding osteogenesis in coralline hydroxyapatite combined with bone marrow cells.

abstract：:A series of coumarin fluorophores (1-3), each bearing a double bond conjugated quinoline unit that can undergo a Michael-type reaction with thiol-containing compounds, is reported. These systems, designed to provide so-called turn-on changes in fluorescence response when exposed to thiols, act as fluorescent chemical ...

journal_title：Biomaterials

authors： Jung HS,Han JH,Pradhan T,Kim S,Lee SW,Sessler JL,Kim TW,Kang C,Kim JS

更新日期：2012-01-01 00:00:00

abstract：:Lingo-1 is selectively expressed on both oligodendrocytes and neurons in the central nervous system (CNS) and serves as a key negative regulator of nerve regeneration, implying a therapeutic target for spinal cord injury (SCI). Here we described a strategy to knock-down Lingo-1 expression in vivo using lentiviral vect...

journal_title：Biomaterials

authors： Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y

更新日期：2013-02-01 00:00:00

abstract：:This study was undertaken to evaluate the role of collagen matrix to enhance platelet-rich plasma (PRP) effects on pro-inflammatory cytokine-induced arthritic model. We have previously demonstrated the highly regenerative roles of PRP to restore disc degeneration and osteoporosis. In this study, PRP modulated by colla...

journal_title：Biomaterials

authors： Wu CC,Chen WH,Zao B,Lai PL,Lin TC,Lo HY,Shieh YH,Wu CH,Deng WP

更新日期：2011-09-01 00:00:00

abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

journal_title：Biomaterials

authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

更新日期：2000-06-01 00:00:00

abstract：:Resurfacing of cartilage defects using cell-seeded, biomaterial grafts is a promising approach for articular cartilage repair and in this study we investigated the ability of human chondrocytes from osteoarthritic joints to generate cartilage tissue under standard conditions in cultured over 21 days on Hyalograft matr...

journal_title：Biomaterials

authors： Katopodi T,Tew SR,Clegg PD,Hardingham TE

更新日期：2009-02-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:The shelf life of implantable materials has rarely been addressed. We determined whether osteoconductivity of titanium is stable over time. Rat bone marrow-derived osteoblasts were cultured on new titanium disks (immediately after acid-etching), 3-day-old (stored after acid-etching for 3 days in dark ambient condition...

journal_title：Biomaterials

authors： Att W,Hori N,Takeuchi M,Ouyang J,Yang Y,Anpo M,Ogawa T

更新日期：2009-10-01 00:00:00

abstract：:Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...

journal_title：Biomaterials

authors： Koller MR,Palsson MA,Manchel I,Maher RJ,Palsson BO

更新日期：1998-11-01 00:00:00

abstract：:Immediate finishing is a highly desirable property of restorative materials. In general, the resin composites, the polyacid-modified resin composites and resin-modified glass-ionomers are finished immediately after light-curing. For the conventional glass-ionomers a waiting period of 24 h is recommended. Therefore, th...

journal_title：Biomaterials

authors： Gladys S,Braem M,Van Meerbeek B,Lambrechts P,Vanherle G

更新日期：1998-03-01 00:00:00

abstract：:The use of a composite graft of bovine trabecular demineralized bone matrix (DBM) and perichondrium has been found a reliable method for in vivo generation of cartilage. In the present study, the mechanism whereby this commercially available matrix increases cartilage formation was investigated. First, the time course...

journal_title：Biomaterials

authors： van Osch GJ,ten Koppel PG,van der Veen SW,Poppe P,Burger EH,Verwoerd-Verhoef HL

更新日期：1999-02-01 00:00:00

abstract：:Efficient and site-specific delivery of anticancer drugs to tumors is important in the development of effective cancer chemotherapy. As an undecapeptide of the tachykinin neuropeptide family, the substance P (SP)/neurokinin-1 receptor (NK1R) system has been identified as a promising ligand-receptor pair in tumor-speci...

journal_title：Biomaterials

authors： Wu J,Zhou Y,Li S,Qu D,Zhu WH,Tian H

更新日期：2017-03-01 00:00:00

abstract：:Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem cells. In this study, we evaluate the potential of thermosensitive hydroxybutyl chitosan (HBC) as a biomaterial for the culture of human mesenchymal stem cells (hM...

journal_title：Biomaterials

authors： Dang JM,Sun DD,Shin-Ya Y,Sieber AN,Kostuik JP,Leong KW

更新日期：2006-01-01 00:00:00

abstract：:Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

journal_title：Biomaterials

authors： Kim MH,Kino-oka M

更新日期：2014-07-01 00:00:00

abstract：:Protein delivery allows a clinical effect to be directly realized without genetic modification of the host cells. We have developed a cationic bolaamphiphile as a non-viral vector for protein delivery application. The relatively low toxicity and efficient protein delivery by the cationic bolaamphiphile prompted us to ...

journal_title：Biomaterials

authors： Khan M,Narayanan K,Lu H,Choo Y,Du C,Wiradharma N,Yang YY,Wan AC

更新日期：2013-07-01 00:00:00

abstract：:Theranostic nanoagents which integrate diagnostic and therapeutic moieties into a single platform have attracted broad attention in cancer therapy, however the development of more effective and less toxic diagnostic and therapeutic interventions is still of great urgency. Herein, novel core-shell PB@MIL-100(Fe) dual m...

journal_title：Biomaterials

authors： Wang D,Zhou J,Chen R,Shi R,Zhao G,Xia G,Li R,Liu Z,Tian J,Wang H,Guo Z,Wang H,Chen Q

更新日期：2016-09-01 00:00:00

abstract：:High throughput cellular studies require small sample volume to reduce costs and enhance sensitivity. Microfluidics-generated water-in-oil (W/O) single emulsion droplet systems, in particular, provide uniform, well defined and discrete microenvironment for cell culture, screening, and sorting. However, these single em...

journal_title：Biomaterials

authors： Zhang Y,Ho YP,Chiu YL,Chan HF,Chlebina B,Schuhmann T,You L,Leong KW

更新日期：2013-06-01 00:00:00

abstract：:To understand the effect of photosensitizer (PS) release from graft copolymer based micelles in photodynamic therapy (PDT), the two pH-sensitive and non-pH-sensitive graft copolymers, (poly(N-vinyly caprolactam)-g-poly(D,L-lactide) and poly(N-vinyly caprolactam-co-N-vinyl imidazole)-g-poly(D,L-lactide)), were synthesi...

journal_title：Biomaterials

authors： Tsai HC,Tsai CH,Lin SY,Jhang CR,Chiang YS,Hsiue GH

更新日期：2012-02-01 00:00:00

abstract：:Calcium phosphate cements were first proposed as synthetic bone substitutes over two decades ago, however, they are characterised by slow chemical or cellular resorption and a slow osteointegration. In contrast, bone autograft has been shown to stimulate osteoclastogenesis and angiogenesis resulting in active bone rem...

journal_title：Biomaterials

authors： Le Nihouannen D,Hacking SA,Gbureck U,Komarova SV,Barralet JE

更新日期：2008-08-01 00:00:00

abstract：:Injectable scaffolds made of biodegradable biomaterials can stabilize a myocardial infarct and promote cardiac repair. Here, we describe the synthesis of a new, temperature-sensitive, aliphatic polyester hydrogel (HG) conjugated with vascular endothelial growth factor (VEGF) and evaluate its effects on cardiac recover...

journal_title：Biomaterials

authors： Wu J,Zeng F,Huang XP,Chung JC,Konecny F,Weisel RD,Li RK

更新日期：2011-01-01 00:00:00

abstract：:Sodium alginate hydrogel, stabilized with gelatin, is a suitable, biologically inert matrix that can be used for encapsulating and 3D bioprinting of bone-related SaOS-2 cells. However, the cells, embedded in this matrix, remain in a non-proliferating state. Here we show that addition of an overlay onto the bioprinted ...

journal_title：Biomaterials

authors： Neufurth M,Wang X,Schröder HC,Feng Q,Diehl-Seifert B,Ziebart T,Steffen R,Wang S,Müller WEG

更新日期：2014-10-01 00:00:00

abstract：:Platelet-derived growth factor BB (PDGF-BB) was an important inductive factor during wound healing, but the lack of efficient delivery system limited its clinical application. Here, a peptide of seven amino acids was firstly utilized to engineer PDGF-BB to construct a collagen-targeting system. This peptide functioned...

journal_title：Biomaterials

authors： Lin H,Chen B,Sun W,Zhao W,Zhao Y,Dai J

更新日期：2006-11-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:Inorganic phosphate (Pi) is a physiological regulator of osteoblasts and chondrocytes, suggesting that phosphate may contribute to the biological response of these cells to bioactive glasses like Bioglass 45S5, which is composed of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5. We investigated the effect of varying the...

journal_title：Biomaterials

authors： Lossdörfer S,Schwartz Z,Lohmann CH,Greenspan DC,Ranly DM,Boyan BD

更新日期：2004-06-01 00:00:00

abstract：:This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...

journal_title：Biomaterials

authors： Li W,Swain MV,Li Q,Ironside J,Steven GP

更新日期：2004-09-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:The search for a cell-supporting scaffold with controlled topography and surface chemistry is a constant topic within tissue engineering. Here we have employed M13 phages, which are genetically modifiable biological nanofibers (∼ 880 nm long and ∼ 6.6 nm wide) non-toxic to human beings, to form films for supporting th...

journal_title：Biomaterials

authors： Zhu H,Cao B,Zhen Z,Laxmi AA,Li D,Liu S,Mao C

更新日期：2011-07-01 00:00:00

abstract：:Chitin grafted with poly(acrylic acid) (chitin-PAA) was prepared with the aim of obtaining a hydrogel characteristic for wound dressing application. The chitin-PAA films were synthesized at various acrylic acid feed contents to investigate its effect on water sorption ability. Acrylic acid (AA) was first linked to chi...

journal_title：Biomaterials

authors： Tanodekaew S,Prasitsilp M,Swasdison S,Thavornyutikarn B,Pothsree T,Pateepasen R

更新日期：2004-03-01 00:00:00

abstract：:Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem™, a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vas...

journal_title：Biomaterials

authors： Aurora A,Roe JL,Corona BT,Walters TJ

更新日期：2015-10-01 00:00:00

abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

journal_title：Biomaterials

authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

更新日期：2003-07-01 00:00:00

abstract：:Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections...

journal_title：Biomaterials

authors： Huang N,Chen X,Zhu X,Xu M,Liu J

更新日期：2017-10-01 00:00:00