Abstract：
:The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By blending the PDL-LA with the ligand-tethered PEO-PPO-PEO derivatives, the surface of modified PDL-LA film was investigated by ATR-FTIR, XPS and contact angle. The chondrocytes test on different PDL-LA films indicated that the PEO-PPO-PEO amino acid and RGD derivatives modified PDL-LA films could promote chondrocyte attachment and growth. This simple surface treatment method may have potentials for tissue engineering and other biomedical applications.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Ji J,Zhu H,Shen Jdoi
10.1016/j.biomaterials.2003.08.031keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
1859-67issue
10eissn
0142-9612issn
1878-5905pii
S0142961203006938journal_volume
25pub_type
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