Abstract：
:A pH-sensitive molecularly imprinted polymer (MIP) nanospheres/hydrogel composite exhibiting controlled release of dexamethasone-21 phosphate disodium (DXP) was developed as a potential coating for implantable biosensors to improve their biocompatibility. The molecularly imprinted pH-sensitive nanospheres were prepared by UV-initiated precipitation polymerization using DXP as the template molecule. The DXP loading and release experiments showed that the MIP nanospheres exhibited a higher loading level and slower release rate than non-imprinted polymer (NIP) nanospheres due to the interaction of DXP with the DXP-imprinted cavities within the MIP nanospheres. Furthermore, the MIP nanospheres exhibited a faster DXP release rate at a lower pH value within the pH range tested (i.e., 6.0-7.4), which is desirable for suppressing inflammation because inflammation induces an acidic microenvironment. In contrast, the NIP nanospheres did not show a notable pH-responsive DXP release behavior. The hydrogel poly(2-hydroxyethyl methacrylate (HEMA) -N-vinyl-2-pyrrolidinone (NVP) -2-methacryloyloxyethyl phosphorylcholine (MPC)) was prepared by UV polymerization. The MIP nanospheres were successfully incorporated into the hydrogel. The equilibrium water content and swelling kinetics of the MIP nanospheres/hydrogel composite were similar to those of pure hydrogel. The MIP nanospheres/hydrogel composite exhibited a much better controlled DXP release profile than the pure hydrogel. This pH-sensitive MIP nanospheres/hydrogel composite designed as a coating for implantable biosensors can potentially suppress the inflammation response of the implanted biosensors efficiently thereby effectively improving their lifetime.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Wang C,Javadi A,Ghaffari M,Gong Sdoi
10.1016/j.biomaterials.2010.02.073subject
Has Abstractpub_date
2010-06-01 00:00:00pages
4944-51issue
18eissn
0142-9612issn
1878-5905pii
S0142-9612(10)00336-4journal_volume
31pub_type
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