Abstract：
OBJECTIVES:To analyze the biocompatibility of multifilament polyester (PET) meshes used for the implantation of auditory brainstem implants in a standardized Wistar rat model (n=29). METHODS:The physical properties of the meshes were examined during surgery. Using a modified plastic embedding, the local tissue reaction and the stability of mesh position in the region of the fourth ventricle were evaluated in section series from day 3 to 64. The cellular reaction was further differentiated using transmission and scanning electron microscopy. RESULTS:PET meshes were stable for handling. However, sharp edges inevitably led to brainstem and cerebellar penetration in some cases. The meshes were preserved in situ in all section series. Positioning was stable with one exception. A sufficient fibroblast and collagen fiber encasement was reached after 14 days. In all cases, no further change was observed through day 64. The host-defense reaction was persistent and characterized by numerous macrophages and foreign-body giant cells. Bacterial infection occurred in three cases. CONCLUSIONS:PET meshes proved to have an acceptable biocompatibility regarding local-tissue reaction in the brain. Modified polymer structures should be developed to reduce risk of injury. Anti-inflammatory surface treatments and monofilament meshes could reduce the infection rate.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Quester R,Hermanns B,Klosterhalfen B,Schröder R,Klug Ndoi
10.1016/s0142-9612(02)00320-4keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
711-21issue
5eissn
0142-9612issn
1878-5905pii
S0142961202003204journal_volume
24pub_type
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