Abstract：
:In this study, we report the systematic comparison of different poly(ethylene glycol) (PEG) self-assembled monolayers on glass with respect to their protein adsorption and cell adhesion resistance. Combining PEGylation with micellar nanolithography allowed the formation of gold nanoparticle arrays on glass and selective coverage of the free glass area by PEG. The gold nanoparticles serve as anchor points for the attachment of individual proteins and peptides such as the cell-matrix adhesion promoting cyclic RGDfK motif or the kinesin motor protein Eg5. The capability of the motor protein to bind microtubules remained unaffected by the immobilization. It was shown that the film thickness of a water swollen PEG layer is crucial to maximize the interaction between proteins and peptides with the nanostructures. Non-specific interaction between cells or microtubules and the surface was minimized. The optimum PEG layer thickness correlated with the size of gold nanoparticles which was approximately 5 nm.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Blümmel J,Perschmann N,Aydin D,Drinjakovic J,Surrey T,Lopez-Garcia M,Kessler H,Spatz JPdoi
10.1016/j.biomaterials.2007.07.038subject
Has Abstractpub_date
2007-11-01 00:00:00pages
4739-47issue
32eissn
0142-9612issn
1878-5905pii
S0142-9612(07)00555-8journal_volume
28pub_type
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