Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery.

abstract：:The flexural strength of five glass ionomers was measured at intervals ranging from 1 h to 3 months after mixing. The pattern of change in flexural strength is material-specific with two water-activated materials having significantly higher long-term flexural strengths than the others. This may be attributable to the ...

journal_title：Biomaterials

authors： Pearson GJ,Atkinson AS

更新日期：1991-09-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaff...

journal_title：Biomaterials

authors： Wan Y,Feng G,Shen FH,Laurencin CT,Li X

更新日期：2008-02-01 00:00:00

abstract：:Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...

journal_title：Biomaterials

authors： Ghandehari H,Kopecková P,Kopecek J

更新日期：1997-06-01 00:00:00

abstract：:Angiogenesis is a complex multistage process involving multiple factors and numerous cells. The use of the Chorioallantoic Membrane (CAM) assay is well documented as a method to investigate angiogenesis. This technique is ideal for screening samples, but requires an objective analysis technique. The angiogenic respons...

journal_title：Biomaterials

authors： Oates M,Chen R,Duncan M,Hunt JA

更新日期：2007-09-01 00:00:00

abstract：:The ultimate goal of implantation of biomaterials in the skeleton is to reach full integration of the non-living implant with the living bone. The biomaterial can be used much as a bone graft, resorbing or dissolving as bone growth occurs, and the end result is a new remoulded bone. Calcium pyrophosphate, Ca2P2O7, is ...

journal_title：Biomaterials

authors： Lin FH,Lin CC,Lu CM,Liu HC,Sun JS,Wang CY

更新日期：1995-07-01 00:00:00

abstract：:G-rich oligonucleotides tend to fall into kinetically trapped unstable structures because of their conformational polymorphism. Nucleic acid chaperones accelerate association of nucleic acids assemblies into the thermodynamically most stable conformations by decreasing the energy barrier for breakage or re-assembly of...

journal_title：Biomaterials

authors： Moriyama R,Shimada N,Kano A,Maruyama A

更新日期：2011-10-01 00:00:00

abstract：:Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-respon...

journal_title：Biomaterials

authors： Wang M,Chen M,Niu W,Winston DD,Cheng W,Lei B

更新日期：2020-12-01 00:00:00

abstract：:The object of this study was to develop a small experimental animal model for a systematic study of the interfacial phenomena between percutaneous implants and skin. Plasma-sprayed and dense hydroxyapatite test implants were inserted into the tibia and dorsum of guinea pigs and into the tibia and on the cranium of rab...

journal_title：Biomaterials

authors： Jansen JA,de Groot K

更新日期：1988-05-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) plays a critical role in the innate immune system. Stimulation of TLR4 occurs upon binding lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls. Due to the potency of the induced inflammatory response, there is a growing interest in agents that can most proximally mod...

journal_title：Biomaterials

authors： Foit L,Thaxton CS

更新日期：2016-09-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:Cutaneous melanoma is an increasingly common and potentially lethal malignancy of melanocytes, the melanin producing cells normally located in the basal layer of the skin epidermis. Despite major advances in cancer chemotherapeutics and immunotherapy, the success in treating metastatic melanoma remains poor. The notio...

journal_title：Biomaterials

authors： Chandrasekaran S,DeLouise LA

更新日期：2011-12-01 00:00:00

abstract：:The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b. Complement consumption is determined by a haemolytic assay CH50. Hydroxyapatite powders after sintering induce a significant conversion of C3 and reduction of ...

journal_title：Biomaterials

authors： Klein CP,de Groot K,van Kamp G

更新日期：1983-07-01 00:00:00

abstract：:Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts o...

journal_title：Biomaterials

authors： Nguyen KT,West JL

更新日期：2002-11-01 00:00:00

abstract：:The objective of this study is to develop a carrier for the controlled release of bone morphogenetic protein-2 (BMP-2) suitable for enhancement of the bone regeneration activity. Hydrogels with different water contents were prepared through glutaraldehyde crosslinking of gelatin with an isoelectric point of 9.0 under ...

journal_title：Biomaterials

authors： Yamamoto M,Takahashi Y,Tabata Y

更新日期：2003-11-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:Heat treatment of an MgO-CaO-SiO2-P2O5 glass gave a glass ceramic containing crystalline apatite (Ca10(PO4)6O,F2] and beta-wollastonite (CaO,SiO2) in an MgO-CaO-SiO2 glassy matrix. It showed bioactivity and a fairly high mechanical strength which decreased only slowly, even under load-bearing conditions in the body. I...

journal_title：Biomaterials

authors： Kokubo T

更新日期：1991-03-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:We have previously shown that the high-affinity streptavidin (SA)-biotin interaction enhanced the initial integrin-mediated adhesion of biotinylated endothelial cells to SA-coated surface by serving as an extrinsic bond to stabilize and enhance the intrinsic fibronectin-integrin binding between the cell and surface. H...

journal_title：Biomaterials

authors： Chan BP,Chilkoti A,Reichert WM,Truskey GA

更新日期：2003-02-01 00:00:00

abstract：:Dacron velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to ...

journal_title：Biomaterials

authors： Paquay YC,de Ruijter JE,van der Waerden JP,Jansen JA

更新日期：1996-06-01 00:00:00

abstract：:Permanent male sterilization has been recognized as useful tools for the development of neuter experimental animals and fattening livestock, as well as efficient control of pet overpopulation. Traditional routes such as surgical ways, chemical injections, and anti-fertility vaccines have addressed these crucial proble...

journal_title：Biomaterials

authors： Liu Z,Liu X,Ran X,Ju E,Ren J,Qu X

更新日期：2015-11-01 00:00:00

abstract：:Recapitulation of the cellular microenvironment of the heart, which promotes cell contraction, remains a key challenge in cardiac tissue engineering. We report here on our work, where for the first time, a 3-dimensional (3D) spring-like fiber scaffold was fabricated, successfully mimicking the coiled perimysial fibers...

journal_title：Biomaterials

authors： Fleischer S,Feiner R,Shapira A,Ji J,Sui X,Daniel Wagner H,Dvir T

更新日期：2013-11-01 00:00:00

abstract：:One of the major limitations of studying cancer-bone metastasis has been the lack of an appropriate ex-vivo model which can be used under defined conditions that simulates closely the in vivo live bone microenvironment in response to cancer-bone interactions. We have developed and utilized a three-dimensional (3D) can...

journal_title：Biomaterials

authors： Curtin P,Youm H,Salih E

更新日期：2012-02-01 00:00:00

abstract：:Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for ...

journal_title：Biomaterials

authors： Song R,Zhang M,Liu Y,Cui Z,Zhang H,Tang Z,Chen X,Wu H,Yao Z,He M,Bu W

更新日期：2018-08-01 00:00:00

abstract：:Virus-based nanoparticles have shown promise as vehicles for delivering therapeutic genes. However, the rational design of viral vectors that enable selective tropism towards particular types of cells and tissues remains challenging. Here, we explored structural-functional relationships of the adeno-associated virus 2...

journal_title：Biomaterials

authors： Zhang C,Yao T,Zheng Y,Li Z,Zhang Q,Zhang L,Zhou D

更新日期：2016-02-01 00:00:00

abstract：:Hybrid drug delivery system containing both organic and inorganic nanocarriers is expected to achieve its complementary advantages for the aim of improving the performance of antineoplastic drugs in tumor therapy. Here we report the use of liposomes and gold nanoparticles to construct a liposome with a hybrid Cluster ...

journal_title：Biomaterials

authors： Zhang N,Chen H,Liu AY,Shen JJ,Shah V,Zhang C,Hong J,Ding Y

更新日期：2016-01-01 00:00:00

abstract：:One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However, there have been no controlled studies to investigate the influence of skeletal maturity on the MSC-based repair of cartilage. The purpose of this study was to compare the ...

journal_title：Biomaterials

authors： Shimomura K,Ando W,Tateishi K,Nansai R,Fujie H,Hart DA,Kohda H,Kita K,Kanamoto T,Mae T,Nakata K,Shino K,Yoshikawa H,Nakamura N

更新日期：2010-11-01 00:00:00

abstract：:The pore architecture in 3-D polymeric scaffoldings plays a critical role in tissue engineering as it provides the framework for the seeded cells to organize into a functioning tissue. In the present paper, we investigate the effect of freezing regime on the pore microstructure in 3-D alginate scaffolds, fabricated by...

journal_title：Biomaterials

authors： Zmora S,Glicklis R,Cohen S

更新日期：2002-10-01 00:00:00

abstract：:An ideal approach for bone tissue engineering allows for osteoconductivity, osteoinductivity, and cell transplantation. In this study, we examined coprecipitation and surface adsorption schemes with respect to their abilities to control the spatial quantity and localization of a model protein, bovine serum albumin (BS...

journal_title：Biomaterials

authors： Luong LN,Hong SI,Patel RJ,Outslay ME,Kohn DH

更新日期：2006-03-01 00:00:00

abstract：:Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms are unknown. In order to investigate the role of 3D cell-cell interactions in maintaining hepatocyte differentiated functions ex vivo, primary mouse hepatocytes were ...

journal_title：Biomaterials

authors： Chang TT,Hughes-Fulford M

更新日期：2014-02-01 00:00:00

abstract：:Our focus was to develop a three-dimensional (3D) human dynamic in vitro tissue model that mimics the natural microenvironment of the small intestine. We co-cultured human Caco-2 cells with primary-isolated human microvascular endothelial cells (hMECs) on decellularized porcine jejunal segments within a custom-made dy...

journal_title：Biomaterials

authors： Pusch J,Votteler M,Göhler S,Engl J,Hampel M,Walles H,Schenke-Layland K

更新日期：2011-10-01 00:00:00