Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy.

abstract：:The purpose of this study was to determine the mechanical properties and the atomistic structures of various gelatin hydrogels as a preliminary to using these in bioengineering applications. The hydrogels were investigated as neat materials and as particulate-reinforced composites both in the as-formed state and follo...

journal_title：Biomaterials

authors： Usta M,Piech DL,MacCrone RK,Hillig WB

更新日期：2003-01-01 00:00:00

abstract：:Renal regeneration approaches offer great potential for the treatment of chronic kidney disease, but their availability remains limited by the clinical challenges they pose. In the present study, we used continuous detergent perfusion to generate decellularized (DC) rat kidney scaffolds. The scaffolds retained intact ...

journal_title：Biomaterials

authors： Yu YL,Shao YK,Ding YQ,Lin KZ,Chen B,Zhang HZ,Zhao LN,Wang ZB,Zhang JS,Tang ML,Mei J

更新日期：2014-08-01 00:00:00

abstract：:Clinically used contrast agents for magnetic resonance imaging (MRI) suffer by the lack of specificity; short circulation time; and insufficient relaxivity. Here, a one-step combinatorial approach is described for the synthesis of magnetic lipid-polymer (hybrid) nanoparticles (MHNPs) encapsulating 5 nm ultra-small sup...

journal_title：Biomaterials

authors： Aryal S,Key J,Stigliano C,Ananta JS,Zhong M,Decuzzi P

更新日期：2013-10-01 00:00:00

abstract：:Due to mild reaction conditions and temporal and spatial control over material formation, photopolymerization has become a valuable technique for the encapsulation of living cells in three dimensional, hydrated, biomimetic materials. For such applications, 2-hydroxy-1-[4-(2-hydroxyethoxy) phenyl]-2-methyl-1-propanone ...

journal_title：Biomaterials

authors： Fairbanks BD,Schwartz MP,Bowman CN,Anseth KS

更新日期：2009-12-01 00:00:00

abstract：:We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also se...

journal_title：Biomaterials

authors： Khoo X,Simons EJ,Chiang HH,Hickey JM,Sabharwal V,Pelton SI,Rosowski JJ,Langer R,Kohane DS

更新日期：2013-01-01 00:00:00

abstract：:The coupling of specific antibodies to imaging agents often improves imaging specificity. However, free amine groups designed for the coupling can cause nonspecific binding of the imaging agents. We report here development of a nanocarrier, MnMEIO-silane-NH2-mPEG nanoparticles (NPs), consisting of a manganese-doped ir...

journal_title：Biomaterials

authors： Wu SC,Lin KL,Wang TP,Tzou SC,Singh G,Chen MH,Cheng TL,Chen CY,Liu GC,Lee TW,Hu SH,Wang YM

更新日期：2013-05-01 00:00:00

abstract：:It is now well accepted that the initial rapid adsorption of blood proteins to biomaterial surfaces is important in the long-term performance of the implant. Cells that interact with the implant will be reacting to a layer (single or multiple) of adsorbed protein. The parameters of importance in a study of protein ads...

journal_title：Biomaterials

authors： Chittur KK

更新日期：1998-03-01 00:00:00

abstract：:A hydroxyapatite (HA) particulate reinforced ultrahigh molecular weight polyethylene (UHMWPE) nanocomposite was fabricated by compounding HA and UHMWPE mixtures in paraffin oil using twin-screw extrusion and then compression molding. Scanning electron microscope images revealed that HA aggregates were broken down to n...

journal_title：Biomaterials

authors： Fang L,Leng Y,Gao P

更新日期：2006-07-01 00:00:00

abstract：:The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

journal_title：Biomaterials

authors： Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

更新日期：1996-02-01 00:00:00

abstract：:Anchorage-dependent cells (NRK 49F) were grown at 37 degrees C in serum containing medium on glass coated with a N-isopropyl acrylamide/N-t-butyl acrylamide copolymer (NIPAaM/NTBAM) with a lower critical solution temperature (LCST) of 8 degrees C. After incubating the dishes and adherent cells at 4 degrees C for 1 h, ...

journal_title：Biomaterials

authors： Rollason G,Davies JE,Sefton MV

更新日期：1993-01-01 00:00:00

abstract：:We introduce a general class of mixture models suitable to describe water-dependent degradation and erosion of biodegradable polymers in conjunction with drug release. The ability to predict and quantify degradation and erosion has direct impact in a variety of biomedical applications and is a useful design tool for b...

journal_title：Biomaterials

authors： Soares JS,Zunino P

更新日期：2010-04-01 00:00:00

abstract：:To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...

journal_title：Biomaterials

authors： Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

更新日期：2009-07-01 00:00:00

abstract：:Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseas...

journal_title：Biomaterials

authors： Gu X,Kwok RTK,Lam JWY,Tang BZ

更新日期：2017-11-01 00:00:00

abstract：:An implantable, anti-microbial delivery device for the treatment of periodontal disease has been developed. In this polymer-based delivery system, the encapsulation efficiency, release characteristics, and bioactivity of anti-microbial agent were controlled by the complexation of the drug with cyclodextrins of differi...

journal_title：Biomaterials

authors： Yue IC,Poff J,Cortés ME,Sinisterra RD,Faris CB,Hildgen P,Langer R,Shastri VP

更新日期：2004-08-01 00:00:00

abstract：:Xenogeneic extracellular matrix (ECM) can be harvested and configured to function as a bioscaffold for tissue and organ reconstruction. The mechanical properties of the ECM vary depending upon the tissue from which it is harvested. Likewise, the manufacturing steps required to develop ECMs into medical grade devices w...

journal_title：Biomaterials

authors： Freytes DO,Badylak SF,Webster TJ,Geddes LA,Rundell AE

更新日期：2004-05-01 00:00:00

abstract：:The influence of crystallization, upon heat treatment, on the properties of high-velocity oxy-fuel (HVOF) sprayed hydroxyapatite (HA) coatings was investigated. The characterization of the HA coating was performed by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). Differential Scanning Calo...

journal_title：Biomaterials

authors： Li H,Khor KA,Cheang P

更新日期：2002-05-01 00:00:00

abstract：:By taking advantage of the excessively upregulated expression of neuropilin (NRP) on the surface of both glioma cells and endothelial cells of angiogenic blood vessels, the ligand of NRP with high affinity - tLyp-1 peptide, which also contains a CendR motif ((R/K)XX(R/K)), was functionalized to the surface of PEG-PLA ...

journal_title：Biomaterials

authors： Hu Q,Gao X,Gu G,Kang T,Tu Y,Liu Z,Song Q,Yao L,Pang Z,Jiang X,Chen H,Chen J

更新日期：2013-07-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:Platinum nanoparticle-doped chitosan (CHIT) solution can be easily prepared by treating the CHIT solution with aqueous H2PtCl6 solution followed by chemical reduction of Pt(IV) with NaBH4. Multiwalled carbon nanotubes (MWCNT) are then dispersed in the nanoparticle-doped solution. The resulting Pt-CNT-CHIT material bri...

journal_title：Biomaterials

authors： Yang M,Yang Y,Yang H,Shen G,Yu R

更新日期：2006-01-01 00:00:00

abstract：:Poly(3, 4-ethylenedioxythiophene)-coated carbon microfibers (PEDOT-MFs) hold promise for developing advanced neuroprostheses and neural repair devices. We investigated the chronic cellular responses to PEDOT-MFs implanted into the uninjured and the transected rat spinal cord, and compared the effects of polymer surfac...

journal_title：Biomaterials

authors： Alves-Sampaio A,García-Rama C,Collazos-Castro JE

更新日期：2016-05-01 00:00:00

abstract：:In order to develop a more effective self-etching primer, with a longer lasting shelf life, we designed a self-etching primer comprised of methacrylamide, N-methacryloyl glycine, NMGly. In this study, the hydrolytic stability of the amide portion in the NMGly was examined. The difference in the hydrolytic stability be...

journal_title：Biomaterials

authors： Nishiyama N,Suzuki K,Yoshida H,Teshima H,Nemoto K

更新日期：2004-03-01 00:00:00

abstract：:It is widely accepted that implant surface factors affect the quality of the bone-to-implant interface. Recent additional treatments superimposed on moderately rough cpTitanium surface provide further enhancement of bone-to-implant contact. The aim of this study was to compare osteoinductive and bone-specific gene exp...

journal_title：Biomaterials

authors： Guo J,Padilla RJ,Ambrose W,De Kok IJ,Cooper LF

更新日期：2007-12-01 00:00:00

abstract：:Microcomputed tomography (micro-CT) is increasingly being used to analyze the three-dimensional structure and architecture of microvascular networks. Therefore we have evaluated a micro-CT analysis of VEGF-induced vessel ingrowth into a porous polyurethane scaffold through comparison with analyses by CD31 immunohistoc...

journal_title：Biomaterials

authors： Schmidt C,Bezuidenhout D,Beck M,Van der Merwe E,Zilla P,Davies N

更新日期：2009-10-01 00:00:00

abstract：:A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformat...

journal_title：Biomaterials

authors： Ferruti P,Penco M,D'Addato P,Ranucci E,Deghenghi R

更新日期：1995-12-01 00:00:00

abstract：:The protective role of different dentine fractions and of dentine slices in moderating the cytotoxicity of zinc oxide eugenol (ZOE) was investigated. The collagen fraction of dentine powder provided increased protection over intact powder. Slices of dentine offered greater protection probably by providing a physical b...

journal_title：Biomaterials

authors： Meryon SD,Jakeman KJ

更新日期：1986-11-01 00:00:00

abstract：:Fungal keratitis is a leading cause of ocular morbidity. It is frequently misdiagnosed as bacterial keratitis, causing a delay in proper treatment. Furthermore, due to the lack of safe and effective anti-fungal agents for clinical use, treatment of fugal keratitis remains a challenge. In recent years, antimicrobial pe...

journal_title：Biomaterials

authors： Wu H,Ong ZY,Liu S,Li Y,Wiradharma N,Yang YY,Ying JY

更新日期：2015-03-01 00:00:00

abstract：:Particle-associated periprosthetic osteolysis remains a major issue in joint replacement. Ongoing bone loss resulting from wear particle-induced inflammation is accompanied by continued attempts at bone repair. Previously we showed that mesenchymal stem cells (MSCs) are recruited systemically to bone exposed to contin...

journal_title：Biomaterials

authors： Gibon E,Yao Z,Rao AJ,Zwingenberger S,Batke B,Valladares R,Smith RL,Biswal S,Gambhir SS,Goodman SB

更新日期：2012-05-01 00:00:00

abstract：:An oxidizing treatment of carbon fibres in boiling nitric acid leads to significant changes in the chemical state of their surface. As a result of the chemical treatment on a hydrophobic carbon surface, hydrophilic domains are formed and phenolic, carbonyl and carboxyl groups appear. In this work the intensity of phag...

journal_title：Biomaterials

authors： Czajkowska B,Błazewicz M

更新日期：1997-01-01 00:00:00

abstract：:In our previous study, a three-dimensional zein porous scaffold with a compressive Young's modulus of up to 86.6+/-19.9 MPa and a compressive strength of up to 11.8+/-1.7 MPa was prepared, and was suitable for culture of mesenchymal stem cells (MSCs) in vitro. In this study, we examined its tissue compatibility in a r...

journal_title：Biomaterials

authors： Wang HJ,Gong SJ,Lin ZX,Fu JX,Xue ST,Huang JC,Wang JY

更新日期：2007-09-01 00:00:00

abstract：:In this study, we quantified the adsorption of immunoglobulin G (IgG) protein onto several polyelectrolyte-modified sintered porous polyethylene (PPE) membranes. The polymer surfaces had both cationic and anionic charges obtained via the adsorption of polyethylenimine (PEI) and polyacrylic acid (PAA), respectively, on...

journal_title：Biomaterials

authors： Greene G,Radhakrishna H,Tannenbaum R

更新日期：2005-10-01 00:00:00