Abstract:
:We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Khoo X,Simons EJ,Chiang HH,Hickey JM,Sabharwal V,Pelton SI,Rosowski JJ,Langer R,Kohane DSdoi
10.1016/j.biomaterials.2012.10.025subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1281-8issue
4eissn
0142-9612issn
1878-5905pii
S0142-9612(12)01146-5journal_volume
34pub_type
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