Abstract：
:In this work, we designed and synthesized an all-in-one zwitterionic material (poly2-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)acetate (pCBMAA-1)) bearing elasticity, switchable antimicrobial/antifouling properties, and stability. Zwitterionic materials have drawn special attention due to their outstanding antifouling properties; however, conventional zwitterionic materials lack tunable elasticity, stability and antimicrobial properties. We addressed these challenges by integrating all desired properties into a single zwitterionic molecule through rational design. pCBMAA-1 hydrogel showed typical elastomeric stress-strain curves with low Young's modulus and high yield strain, in both tensile and compression tests. About 65% tensile strain and 85% compressive strain were achieved. pCBMAA-1 hydrogel can switch between cationic antimicrobial form and zwitterionic antifouling form. In its cationic ring form, pCBMAA-1 hydrogel killed 99.5% of attached bacterial cells and then released 95% of killed cells. pCBMAA-1 surfaces highly resisted the protein adsorption from 100% blood plasma and serum. The amount of adsorbed protein was below the detection limit (0.3 ng cm(-2)) of the SPR sensor. Compared to existing zwitterionic materials, this material showed the dramatically improved stability in both basic and acidic conditions. We believe that this all-in-one material will broaden the application spectrum of zwitterionic materials to a great extent.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Cao B,Li L,Tang Q,Cheng Gdoi
10.1016/j.biomaterials.2013.06.063subject
Has Abstractpub_date
2013-10-01 00:00:00pages
7592-600issue
31eissn
0142-9612issn
1878-5905pii
S0142-9612(13)00778-3journal_volume
34pub_type
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