Abstract:
:The adhesion of osteoblasts to substrates is mediated through proteins that have adsorbed to the substrate, providing integrins on the cell membrane with ligands to connect to. The integrins regulate cell behavior through bi-directional signaling pathways. This critical review has the purpose to consider the research that has been performed with osteoblasts, integrins, and bone replacing materials. Until now, most research has been done to investigate the integrin expression of osteoblasts in culture during cellular adhesion. However, it remains difficult to draw general conclusions from this research. Nevertheless, it can be concluded that the used substrates and protein or peptide coatings can influence the integrin expression and cellular behavior. Additional research has to be done to fully understand all the parameters involved in integrin expression, the adhesion of cells to substrates, and the subsequent cellular behavior. For this purpose, model substrates are under development. The signaling pathway is receiving more and more attention, but for biomaterial purposes, too little consideration is paid to the translation of the in vitro results to the in vivo situation, and to practical applications.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Siebers MC,ter Brugge PJ,Walboomers XF,Jansen JAdoi
10.1016/j.biomaterials.2004.02.021keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
137-46issue
2eissn
0142-9612issn
1878-5905pii
S0142961204001607journal_volume
26pub_type
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