The effect of gelatin incorporation into electrospun poly(L-lactide-co-epsilon-caprolactone) fibers on mechanical properties and cytocompatibility.

abstract：:Isolated hepatocytes in spheroid configuration exhibit a high degree of cell-cell contacts, which are important in the maintenance of viability and liver specific functions. In the absence of a vascular network, the cells in a large spheroid size experience mass transfer limitations of metabolites and oxygen in the co...

journal_title：Biomaterials

authors： Curcio E,Salerno S,Barbieri G,De Bartolo L,Drioli E,Bader A

更新日期：2007-12-01 00:00:00

abstract：:Ectopic transplantation of islets provides a beta cell-replacement approach that may allow the recovery of physiological regulation of the blood sugar level in patients with Type I diabetes (T1D). In development of new extrahepatic islet transplantation protocols in support of the islet engraftment, it is pivotal to d...

journal_title：Biomaterials

authors： Wang X,Wang K,Zhang W,Qiang M,Luo Y

更新日期：2017-09-01 00:00:00

abstract：:Bone morphogenetic protein-2/absorbable collagen sponge (BMP-2/ACS) implants have been approved for clinical use to induce bone regeneration. We previously showed that exaggerated inflammation characterized by elevated level of inflammatory cytokines including TNF-α, IL-1β, and IL-6 has been shown to inhibit BMP-2/ACS...

journal_title：Biomaterials

authors： Huang RL,Chen G,Wang W,Herller T,Xie Y,Gu B,Li Q

更新日期：2015-10-01 00:00:00

abstract：:Stem cell transplantation is a promising therapeutic strategy for acute or chronic ischemic cardiomyopathy. A major limitation to efficacy in cell transplantation is the low efficiency of retention and engraftment, due at least in part to significant early "wash-out" of cells from coronary blood flow and heart contrac...

journal_title：Biomaterials

authors： Vandergriff AC,Hensley TM,Henry ET,Shen D,Anthony S,Zhang J,Cheng K

更新日期：2014-10-01 00:00:00

abstract：:Calcium phosphate ceramics used for clinical applications vary considerably in their phase composition. A range of hydroxyapatite and tricalcium phosphate powders, some of which are used in plasma-sprayed coatings for metal prostheses, were found to leach substances which change the pH of water and cell culture medium...

journal_title：Biomaterials

authors： Sharpe JR,Sammons RL,Marquis PM

更新日期：1997-03-01 00:00:00

abstract：:Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, po...

journal_title：Biomaterials

authors： Hernández-Rivera M,Zaibaq NG,Wilson LJ

更新日期：2016-09-01 00:00:00

abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...

journal_title：Biomaterials

authors： Beamish JA,Geyer LC,Haq-Siddiqi NA,Kottke-Marchant K,Marchant RE

更新日期：2009-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

journal_title：Biomaterials

authors： Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

更新日期：2016-01-01 00:00:00

abstract：:Recently, chitosan-gelatin scaffolds have gained much attention in various tissue engineering applications. However, the underlying cell-matrix interactions remain unclear in addition to the scaffold degradation and mechanical characteristics. In this study, we evaluated (i) the degradation kinetics of chitosan and ch...

journal_title：Biomaterials

authors： Huang Y,Onyeri S,Siewe M,Moshfeghian A,Madihally SV

更新日期：2005-12-01 00:00:00

abstract：:Materials used for total knee arthroplasty (TKA), may elicit an immune response whose role in the outcome of the arthroplasty is still unclear. The aim of this study was to evaluate the frequency of sensitization in patients who had undergone TKA, and the clinical impact of this event on the outcome of the implant. Ni...

journal_title：Biomaterials

authors： Granchi D,Cenni E,Tigani D,Trisolino G,Baldini N,Giunti A

更新日期：2008-04-01 00:00:00

abstract：:Hydrogels are frequently employed as medical device biomaterials due to their advantageous biological properties, e.g. resistance to infection and encrustation, biocompatibility; however, their poor mechanical properties generally limit the scope of application to coatings of medical devices. To address this limitatio...

journal_title：Biomaterials

authors： Jones DS,McLaughlin DW,McCoy CP,Gorman SP

更新日期：2005-05-01 00:00:00

abstract：:The Raman laser and infrared spectra of doped bio-active glasses of the 45S5 type are presented and discussed. The spectroscopic results show that the doping agents cause the destruction of the basic glass structure and the consequent formation of SiO4(4-) units in the glass network. When the doped glasses have been i...

journal_title：Biomaterials

authors： Krajewski A,Ravaglioli A,Bertoluzza A,Monti P,Battaglia MA,Pizzoferrato A,Olmi R,Moroni A

更新日期：1988-11-01 00:00:00

abstract：:Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stab...

journal_title：Biomaterials

authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoit JP

更新日期：2003-10-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:The fracture toughness of three polymethacrylate contact lens hydrogel materials was measured using the method of Generalized Fracture Mechanics. One hydrogel (SNOFLEX S68) had a significantly higher fracture energy per unit area (Jc) than the others, probably because it undergoes plastic deformation at high strains. ...

journal_title：Biomaterials

authors： Jackson AP

更新日期：1990-08-01 00:00:00

abstract：:A cardiomyocyte-targeted Fas siRNA delivery system was developed using prostaglandin E(2) (PGE(2))-modified siRNA polyplexes formed by a reducible poly(amido amine) to inhibit cardiomyocyte apoptosis. PGE(2), which was used as a specific ligand for cardiomyocyte targeting, was conjugated to the terminal-end of the sen...

journal_title：Biomaterials

authors： Kim SH,Jeong JH,Ou M,Yockman JW,Kim SW,Bull DA

更新日期：2008-11-01 00:00:00

abstract：:Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loa...

journal_title：Biomaterials

authors： Xu C,Chen F,Valdovinos HF,Jiang D,Goel S,Yu B,Sun H,Barnhart TE,Moon JJ,Cai W

更新日期：2018-05-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:To broaden the clinical application of cartilage regenerative medicine, we should develop an implant-type tissue-engineered cartilage with firmness and 3-D structure. For that, we attempted to use a porous biodegradable polymer scaffold in the combination with atelocollagen hydrogel, and optimized the structure and co...

journal_title：Biomaterials

authors： Tanaka Y,Yamaoka H,Nishizawa S,Nagata S,Ogasawara T,Asawa Y,Fujihara Y,Takato T,Hoshi K

更新日期：2010-06-01 00:00:00

abstract：:It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types. However, whether biomaterials are associated with the senescence of cultured cells is not known. The present work shows that the decrease of the hydrophobic property of poly (ethylene...

journal_title：Biomaterials

authors： Lou PJ,Chiu MY,Chou CC,Liao BW,Young TH

更新日期：2010-03-01 00:00:00

abstract：:Human stem cells are vulnerable to unfavorable conditions, and their transportation relies on costly and inconvenient cryopreservation. We report here that human mesenchymal stem cells (MSC) in spheroids survived ambient conditions (AC) many days longer than in monolayer. Under AC, the viability of MSC in spheroids re...

journal_title：Biomaterials

authors： Jiang B,Yan L,Miao Z,Li E,Wong KH,Xu RH

更新日期：2017-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been extensively investigated to promote vascularization at damaged or diseased sites and in tissue implants. Here we are interested in determining if the manner in which VEGF is presented from a scaffold to endothelial cells influences the architecture of the blood vessel...

journal_title：Biomaterials

authors： Anderson SM,Siegman SN,Segura T

更新日期：2011-10-01 00:00:00

abstract：:One of the most common non-viral methods for the introduction of foreign deoxyribonucleic acid (DNA) into cultured cells is calcium phosphate co-precipitate transfection. This technique involves the encapsulation of DNA within a calcium phosphate co-precipitate, particulate addition to in vitro cell culture, endocytos...

journal_title：Biomaterials

authors： Kofron MD,Laurencin CT

更新日期：2004-06-01 00:00:00

abstract：:A "room-temperature" injection molding approach combined with particulate leaching (RTIM/PL) has been, for the first time, developed in this work to fabricate three-dimensional porous scaffolds composed of biodegradable polyesters for tissue engineering. In this approach, a "wet" composite of particulate/polymer/solve...

journal_title：Biomaterials

authors： Wu L,Jing D,Ding J

更新日期：2006-01-01 00:00:00

abstract：:The in vivo evaluation, in New Zealand rabbits, of a SiO(2)-P(2)O(5)-CaO sol-gel glass and a SiO(2)-P(2)O(5)-CaO-MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5mm in diameter and 4mm in depth, wer...

journal_title：Biomaterials

authors： Gil-Albarova J,Garrido-Lahiguera R,Salinas AJ,Román J,Bueno-Lozano AL,Gil-Albarova R,Vallet-Regí M

更新日期：2004-08-01 00:00:00

abstract：:Despite serving as the clinical "gold standard" treatment for critical size bone defects, decellularized allografts suffer from long-term failure rates of ~60% due to the absence of the periosteum. Stem and osteoprogenitor cells within the periosteum orchestrate autograft healing through host cell recruitment, which i...

journal_title：Biomaterials

authors： Li Y,Hoffman MD,Benoit DSW

更新日期：2021-01-01 00:00:00

abstract：:Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo o...

journal_title：Biomaterials

authors： Oliveira JM,Rodrigues MT,Silva SS,Malafaya PB,Gomes ME,Viegas CA,Dias IR,Azevedo JT,Mano JF,Reis RL

更新日期：2006-12-01 00:00:00

abstract：:Although dendritic nanoparticles have been prepared by many different methods, control over their degree of branching (DB) is still impossible, preventing us from understanding the effect of the DB on the properties of the nanodendrites as cancer therapeutics. Herein, we developed a novel seed-mediated method to prepa...

journal_title：Biomaterials

authors： Qiu P,Yang M,Qu X,Huai Y,Zhu Y,Mao C

更新日期：2016-10-01 00:00:00

abstract：:The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer vaccines, as they c...

journal_title：Biomaterials

authors： Molino NM,Neek M,Tucker JA,Nelson EL,Wang SW

更新日期：2016-04-01 00:00:00

abstract：:The rationale behind this work is to design an implant device, based on a ferromagnetic material, with the potential to deform in vivo promoting osseointegration through the growth of a healthy periprosthetic bone structure. One of the primary requirements for such a device is that the material should be non-inflammat...

journal_title：Biomaterials

authors： Malheiro VN,Spear RL,Brooks RA,Markaki AE

更新日期：2011-10-01 00:00:00