The in vivo performance of a sol-gel glass and a glass-ceramic in the treatment of limited bone defects.

abstract：:Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their th...

journal_title：Biomaterials

authors： Lu M,Huang Y

更新日期：2020-03-02 00:00:00

abstract：:The application of non-viral gene delivery vectors is often accompanied with the poor correlation between transfection efficiency and the safety profiles of vectors. Vectors with high transfection efficiencies often suffer from high toxicities, making it unlikely to improve their efficiencies by increasing the DNA dos...

journal_title：Biomaterials

authors： Zheng N,Yin L,Song Z,Ma L,Tang H,Gabrielson NP,Lu H,Cheng J

更新日期：2014-01-01 00:00:00

abstract：:Bioprosthetic heart valves fail as the result of two simultaneous processes: structural deterioration and calcification. Leaflet deterioration and perforation have been correlated with regions of highest stress in the tissue. The failures have long been assumed to be due to simple mechanical fatigue of the collagen fi...

journal_title：Biomaterials

authors： Ellsmere JC,Khanna RA,Lee JM

更新日期：1999-06-01 00:00:00

abstract：:Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NP...

journal_title：Biomaterials

authors： Ye H,Wang K,Wang M,Liu R,Song H,Li N,Lu Q,Zhang W,Du Y,Yang W,Zhong L,Wang Y,Yu B,Wang H,Kan Q,Zhang H,Wang Y,He Z,Sun J

更新日期：2019-06-01 00:00:00

abstract：:Recently, engineering the surface of nanotherapeutics with biologics to provide them with superior biocompatibility and targeting towards pathological tissues has gained significant popularity. Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles...

journal_title：Biomaterials

authors： Evangelopoulos M,Parodi A,Martinez JO,Yazdi IK,Cevenini A,van de Ven AL,Quattrocchi N,Boada C,Taghipour N,Corbo C,Brown BS,Scaria S,Liu X,Ferrari M,Tasciotti E

更新日期：2016-03-01 00:00:00

abstract：:This study investigated the in vitro effects of akermanite, a new kind of Ca-, Mg-, Si-containing bioceramic, on the attachment, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs). Parallel comparison of the cellular behaviors of hASCs on the akermanite was made with those on beta...

journal_title：Biomaterials

authors： Liu Q,Cen L,Yin S,Chen L,Liu G,Chang J,Cui L

更新日期：2008-12-01 00:00:00

abstract：:Development of high selectivity, accurate targeted and noninvasive fluorescent probe for monitoring specific enzyme activity associated with the tumor is urgent needed for early diagnosis of cancer and clinical fluorescence interventional resection guidance treatment. Owing to the invasion of malignant tumor cells, tu...

journal_title：Biomaterials

authors： Li H,Yao Q,Xu F,Xu N,Duan R,Long S,Fan J,Du J,Wang J,Peng X

更新日期：2018-10-01 00:00:00

abstract：:In this work, an N-varied dissipative particle dynamics (DPD) simulation technique is applied to investigate detailed endocytosis kinetics for ligand-coated nanoparticles with different shapes, including sphere-, rod- and disk-shaped nanoparticles. Our results indicate that the rotation of nanoparticles, which is one ...

journal_title：Biomaterials

authors： Li Y,Yue T,Yang K,Zhang X

更新日期：2012-06-01 00:00:00

abstract：:The application of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) for sustained and controlled delivery of hydrophilic insulin was made possible by preparing insulin phospholipid complex loaded biodegradable PHBHHx nanoparticles (INS-PLC-NPs). The INS-PLC-NPs produced by a solvent evaporation method showed a spher...

journal_title：Biomaterials

authors： Peng Q,Zhang ZR,Gong T,Chen GQ,Sun X

更新日期：2012-02-01 00:00:00

abstract：:A novel technique has been developed for microstructural studies of bone. The spatial organizations of the mineral and collagen fibres in bone have been a matter of discussion for some time, with numerous diverse observations arising from various preparative techniques. In this latest investigation details of the mine...

journal_title：Biomaterials

authors： Green M,Isaac DH,Jenkins GM

更新日期：1985-05-01 00:00:00

abstract：:A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (perfluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafio...

journal_title：Biomaterials

authors： Gopalan AI,Lee KP,Ragupathy D,Lee SH,Lee JW

更新日期：2009-10-01 00:00:00

abstract：:The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodiu...

journal_title：Biomaterials

authors： Repka MA,McGinity JW

更新日期：2000-07-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuroendocrine factor that activates both the receptor VPAC1 and VPAC2. Although PACAP possesses insulinotropic activity, its therapeutic application is limited by the extremely short acting half-life and the stimulatory effects on glucagon production via...

journal_title：Biomaterials

authors： Ma Y,Fang S,Zhao S,Wang X,Wang D,Ma M,Luo T,Hong A

更新日期：2015-05-01 00:00:00

abstract：:Development of biochips containing living cells for biodetection, drug screening and tissue engineering applications is limited by a lack of reconfigurable material interfaces and actuators. Here we describe a new class of nanostructured magnetizable materials created with a femtosecond laser surface etching technique...

journal_title：Biomaterials

authors： Polte TR,Shen M,Karavitis J,Montoya M,Pendse J,Xia S,Mazur E,Ingber DE

更新日期：2007-06-01 00:00:00

abstract：:Targeted uptake of nanoscale controlled release polymer micelles encapsulated with drugs represents a potential powerful therapeutic technology. Herein we reported the development of anti-HIF-1alpha antibody-conjugated unimolecular polymer nano micelles filled with Paclitaxel for cancer targeting therapy. Pluronic tri...

journal_title：Biomaterials

authors： Song H,He R,Wang K,Ruan J,Bao C,Li N,Ji J,Cui D

更新日期：2010-03-01 00:00:00

abstract：:Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...

journal_title：Biomaterials

authors： Lomas RJ,Gillan HL,Matthews JB,Ingham E,Kearney JN

更新日期：2001-05-01 00:00:00

abstract：:Membranes, clinically used to improve bone regeneration according to the osteopromotion principle, have primarily been made of expanded polytetrafluoroethylene (Gore-Tex Membrane). Recently, different types of biodegradable membranes have become available. This investigation explored the osteopromotive potential of 10...

journal_title：Biomaterials

authors： Zellin G,Gritli-Linde A,Linde A

更新日期：1995-05-01 00:00:00

abstract：:The stabilities of two types of polymerically stabilized liposomes consisting of PEG-grafted (DSPC:CHOL:DSPE-PEG1900, 5:4:1) and physically adsorbed carboxymethylchitin (CMC) and carboxymethyl/glycolchitin (CO) are compared. The polyelectrolyte is adsorbed on positive (DSPC:CHOL:DMTAP, 5:4:1) and neutral (DSPC:CHOL, 1...

journal_title：Biomaterials

authors： Mobed M,Chang TM

更新日期：1998-07-01 00:00:00

abstract：:The oriented attachment of hydroxyapatite (HAP) nanorods was achieved through a hydrothermal treatment. The nanorods were arranged in order along the c-axis of the HAP. These formed ca. 3.5 slip-shaped pores between the rods. High-resolution transmission electron (HRTEM) also revealed that single crystals of HAP may g...

journal_title：Biomaterials

authors： Chen JD,Wang YJ,Wei K,Zhang SH,Shi XT

更新日期：2007-05-01 00:00:00

abstract：:Macropores in tissue engineering scaffolds provide space for vascularization, cell-proliferation and cellular interactions, and is crucial for successful tissue regeneration. Modulating the size and density of macropores may promote desirable cellular processes at different stages of tissue development. Most current t...

journal_title：Biomaterials

authors： Han LH,Lai JH,Yu S,Yang F

更新日期：2013-06-01 00:00:00

abstract：:Macrophages are multifunctional immune cells with diverse physiological functions such as fighting against infection, influencing progression of pathologies, maintaining homeostasis, and regenerating tissues. Macrophages can be induced to adopt distinct polarized phenotypes, such as classically activated pro-inflammat...

journal_title：Biomaterials

authors： Kang H,Zhang K,Wong DSH,Han F,Li B,Bian L

更新日期：2018-09-01 00:00:00

abstract：:Collagenous xenografts made from kangaroo tail tendon cross-linked with glutaraldehyde have a potential application in the reconstruction of massive digital tendon deficits. However, a limitation to the clinical use of these xenografts has been the optimization of collagen cross-linking, and subsequent bio-incorporati...

journal_title：Biomaterials

authors： Johnson KA,Rogers GJ,Roe SC,Howlett CR,Clayton MK,Milthorpe BK,Schindhelm K

更新日期：1999-06-01 00:00:00

abstract：:The first calcium phosphate cements (CPCs) were discovered in the 1980s. Two decades later, the interest for these materials is still rising. The goal of the present document is to review the most recent achievements in the field and to analyze future directions in research and development. ...

journal_title：Biomaterials

authors： Bohner M,Gbureck U,Barralet JE

更新日期：2005-11-01 00:00:00

abstract：:A new family of poly(anhydrides) (PA) has been developed which can be cured photochemically to produce degradable networks. These degradable anhydride networks may be useful in orthopaedics as bone cements and as matrices for drug delivery. This system, which is a semi-interpenetrating network (semi-IPN), has been eva...

journal_title：Biomaterials

authors： Shastri VP,Padera RF,Tarcha P,Langer R

更新日期：2004-02-01 00:00:00

abstract：:Extracellular matrix (ECM) based biomaterials have an established place as medical devices for wound healing and tissue regeneration. In the search for biomaterials we have identified ovine forestomach matrix (OFM), a thick, large format ECM which is biochemically diverse and biologically functional. OFM was purified ...

journal_title：Biomaterials

authors： Lun S,Irvine SM,Johnson KD,Fisher NJ,Floden EW,Negron L,Dempsey SG,McLaughlin RJ,Vasudevamurthy M,Ward BR,May BC

更新日期：2010-06-01 00:00:00

abstract：:Neural transplantation therapy using neural stem cells has received as potential treatments for neurodegenerative diseases. Indeed, this therapy is thought to be effective for replacement of degenerating neurons in restricted anatomical region. However, because injected neural stem cells integrate randomly into the ho...

journal_title：Biomaterials

authors： Kato-Negishi M,Tsuda Y,Onoe H,Takeuchi S

更新日期：2010-12-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:This study describes a family of hollow nanoscale constructs able to display a large and reversible change in size, within a narrow temperature interval. These thermoresponsive nanostructures are generated by crosslinking functionalized amphiphilic molecules, such as poly(ethylene oxide)-poly(propylene oxide)-poly(eth...

journal_title：Biomaterials

authors： Cohn D,Sagiv H,Benyamin A,Lando G

更新日期：2009-07-01 00:00:00

abstract：:Reactive diluents such as triethyleneglycol-dimethacrylate (TEGDMA) have been widely used with bisphenol-A-glycidyl-dimethacrylate (Bis-GMA) to achieve restorative resins with appropriate viscosity and higher conversion. However, additional water sorption and polymerization shrinkage were also introduced. The aim of t...

journal_title：Biomaterials

authors： Lu H,Stansbury JW,Nie J,Berchtold KA,Bowman CN

更新日期：2005-04-01 00:00:00