Abstract:
:A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (perfluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafion-silica nanocomposite. Field emission scanning electron microscopy (FE-SEM) of Nafion-silica/MWNT-g-PANI composite reveals the presence of spherical silica particles (sizes in the range 250 nm-1 microm) and tubular MWNT-g-PANI particles. Chronoamperometry and cyclic voltammetry were used to evaluate the performance of biosensor towards glucose. The Nafion-silica/MWCNT-g-PANI/GOx biosensor exhibited a linear response to glucose in the concentration range of 1-10 mm with a correlation coefficient of 0.9972, good sensitivity (5.01 microA/mm), a low response time (approximately 6s), repeatability (R.S.D value of 2.2%) and along-term stability. The presence of silica network within Nafion and MWNT-g-PANI synergistically contributes to the performance of the biosensor towards the electrochemical detection of glucose.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Gopalan AI,Lee KP,Ragupathy D,Lee SH,Lee JWdoi
10.1016/j.biomaterials.2009.07.047subject
Has Abstractpub_date
2009-10-01 00:00:00pages
5999-6005issue
30eissn
0142-9612issn
1878-5905pii
S0142-9612(09)00787-Xjournal_volume
30pub_type
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