Study of the initial stages of drug release from a degradable matrix of poly(d,l-lactide-co-glycolide).

abstract：:It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types. However, whether biomaterials are associated with the senescence of cultured cells is not known. The present work shows that the decrease of the hydrophobic property of poly (ethylene...

journal_title：Biomaterials

authors： Lou PJ,Chiu MY,Chou CC,Liao BW,Young TH

更新日期：2010-03-01 00:00:00

abstract：:The management of trauma-associated nerve defects is difficult because of the absence of autologous donor motor or sensory nerves. Pre-clinical development and clinical experience has shown that damaged nerves can be surgically repaired using a tubular conduit interposed across the defect. Acceptable patient outcomes ...

journal_title：Biomaterials

authors： Sierpinski P,Garrett J,Ma J,Apel P,Klorig D,Smith T,Koman LA,Atala A,Van Dyke M

更新日期：2008-01-01 00:00:00

abstract：:Designing biomaterial scaffolds remains a major challenge in tissue engineering. Key to this challenge is improved understanding of the relationships between the scaffold properties and its degradation kinetics, as well as the cell interactions and the promotion of new matrix deposition. Here we present the use of non...

journal_title：Biomaterials

authors： Rice WL,Firdous S,Gupta S,Hunter M,Foo CW,Wang Y,Kim HJ,Kaplan DL,Georgakoudi I

更新日期：2008-05-01 00:00:00

abstract：:Sintered bovine cancellous bone exhibited excellent biocompatiblity, high porosity and have an interconnecting porous structure allowing for bone ingrowth. However, the main mineral constitution of sintered bovine bone-hydroxyapatite (Ca10(PO4)6(OH)2, HAP) seems to be too stable in vivo. For improving its bioactivity,...

journal_title：Biomaterials

authors： Lin FH,Liao CJ,Chen KS,Sun JS

更新日期：1999-03-01 00:00:00

abstract：:Implantation of skeletal myoblasts to the heart has been investigated as a means to regenerate and protect the myocardium from damage after myocardial infarction. While several animal studies utilizing skeletal myoblasts have reported positive findings, results from clinical studies have been mixed. In this study we u...

journal_title：Biomaterials

authors： McGinn AN,Nam HY,Ou M,Hu N,Straub CM,Yockman JW,Bull DA,Kim SW

更新日期：2011-01-01 00:00:00

abstract：:Polyetheretherketone-hydroxyapatite composites were developed as alternative materials for load-bearing orthopedic applications. The amount of hydroxyapatite (HA) incorporated into the polyetheretherketone (PEEK) polymer matrix ranges from 5 to 40 vol% and these materials were successfully fabricated by injection mold...

journal_title：Biomaterials

authors： Abu Bakar MS,Cheng MH,Tang SM,Yu SC,Liao K,Tan CT,Khor KA,Cheang P

更新日期：2003-06-01 00:00:00

abstract：:Chondrocytes isolated from human foetal epiphyseal cartilage were seeded dynamically into polyglycolic acid (PGA) scaffolds and cultured in recirculation column bioreactors to produce tissue-engineered cartilage. Several culture techniques with the potential to provide endogenous growth factors and other conditions be...

journal_title：Biomaterials

authors： Mahmoudifar N,Doran PM

更新日期：2005-12-01 00:00:00

abstract：:Chitosan-silica xerogel hybrid membranes were fabricated using a sol-gel process and their potential applications in guided bone regeneration (GBR) were investigated in terms of their in vitro cellular activity and in vivo bone regeneration ability. TEM observation revealed that the silica xerogel was dispersed in the...

journal_title：Biomaterials

authors： Lee EJ,Shin DS,Kim HE,Kim HW,Koh YH,Jang JH

更新日期：2009-02-01 00:00:00

abstract：:The introduction of vaccines is regarded as one of the most successful medical interventions to date. However, there is a clear need for the development of new vaccines for diseases which require the induction of a potent cellular immune response. Advancements in the field of vaccine research have resulted in a move a...

journal_title：Biomaterials

authors： Moran HBT,Turley JL,Andersson M,Lavelle EC

更新日期：2018-11-01 00:00:00

abstract：:Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt e...

journal_title：Biomaterials

authors： Loessner D,Rockstroh A,Shokoohmand A,Holzapfel BM,Wagner F,Baldwin J,Boxberg M,Schmalfeldt B,Lengyel E,Clements JA,Hutmacher DW

更新日期：2019-01-01 00:00:00

abstract：:The effect of hirudin, a known inhibitor of thrombin, was evaluated for whole blood samples in terms of platelet deposition/adhesion to a non-biological test surface (tetrafluoroethylene-propylene copolymer), adenosine diphosphate (ADP) release and reduction in platelet count during laminar shear flow for a shear rate...

journal_title：Biomaterials

authors： Alkhamis TM,Beissinger RL,Chediak JR

更新日期：1993-09-01 00:00:00

abstract：:Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodis...

journal_title：Biomaterials

authors： Harmsen S,Medine EI,Moroz M,Nurili F,Lobo J,Dong Y,Turkekul M,Pillarsetty NVK,Ting R,Ponomarev V,Akin O,Aras O

更新日期：2020-12-23 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:The search for a cell-supporting scaffold with controlled topography and surface chemistry is a constant topic within tissue engineering. Here we have employed M13 phages, which are genetically modifiable biological nanofibers (∼ 880 nm long and ∼ 6.6 nm wide) non-toxic to human beings, to form films for supporting th...

journal_title：Biomaterials

authors： Zhu H,Cao B,Zhen Z,Laxmi AA,Li D,Liu S,Mao C

更新日期：2011-07-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Polyacrylamide hydrogels have been used extensively to study cell responses to the mechanical and biochemical properties of extracellular matrix substrates. A key step in fabricating these substrates is the conjugation of cell adhesion proteins to the polyacrylamide surfaces, which typically involves nonspecifically a...

journal_title：Biomaterials

authors： Lee JP,Kassianidou E,MacDonald JI,Francis MB,Kumar S

更新日期：2016-09-01 00:00:00

abstract：:The Raman laser and infrared spectra of doped bio-active glasses of the 45S5 type are presented and discussed. The spectroscopic results show that the doping agents cause the destruction of the basic glass structure and the consequent formation of SiO4(4-) units in the glass network. When the doped glasses have been i...

journal_title：Biomaterials

authors： Krajewski A,Ravaglioli A,Bertoluzza A,Monti P,Battaglia MA,Pizzoferrato A,Olmi R,Moroni A

更新日期：1988-11-01 00:00:00

abstract：:The formation of bone tissue in pores, and around, a block made of partially dehydroxylated porous hydroxyapatite ceramic and implanted into a rat's femur using X-ray diffraction (XRD), infrared spectroscopy (IRS) and histological methods were investigated. Structural characteristics and composition of new bone tissue...

journal_title：Biomaterials

authors： Zyman Z,Ivanov I,Glushko V,Dedukh N,Malyshkina S

更新日期：1998-07-01 00:00:00

abstract：:Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) and poly(epsilon-caprolactone) (PCL) were obtained using met...

journal_title：Biomaterials

authors： Kwon IK,Kidoaki S,Matsuda T

更新日期：2005-06-01 00:00:00

abstract：:New light-activation units equipped with high-illuminant blue light-emitting diodes (LEDs) have recently been proposed as a replacement for the halogen units that are widely used in dentistry to polymerize light-cured resins. The photoinitiators in light-cured dental resins, typified by the camphorquinone (CQ)/amine p...

journal_title：Biomaterials

authors： Teshima W,Nomura Y,Tanaka N,Urabe H,Okazaki M,Nahara Y

更新日期：2003-05-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaff...

journal_title：Biomaterials

authors： Wan Y,Feng G,Shen FH,Laurencin CT,Li X

更新日期：2008-02-01 00:00:00

abstract：:We have previously shown that the high-affinity streptavidin (SA)-biotin interaction enhanced the initial integrin-mediated adhesion of biotinylated endothelial cells to SA-coated surface by serving as an extrinsic bond to stabilize and enhance the intrinsic fibronectin-integrin binding between the cell and surface. H...

journal_title：Biomaterials

authors： Chan BP,Chilkoti A,Reichert WM,Truskey GA

更新日期：2003-02-01 00:00:00

abstract：:Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatfo...

journal_title：Biomaterials

authors： Zhang C,Liu WL,Bai XF,Cheng SX,Zhong ZL,Zhang XZ

更新日期：2019-04-01 00:00:00

abstract：:Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epitheli...

journal_title：Biomaterials

authors： Monteiro N,Smith EE,Angstadt S,Zhang W,Khademhosseini A,Yelick PC

更新日期：2016-11-01 00:00:00

abstract：:For cardiovascular biomaterials, thrombosis, thromboembolism and vascular graft occlusion are believed to be precipitated by the adsorption of proteins containing adhesive ligands for platelets. Polyethylene-glycol-diisocyanate (PEG-diisocyanate, 3400 MW) may potentially react with protein amines to form molecular bar...

journal_title：Biomaterials

authors： Deible CR,Petrosko P,Johnson PC,Beckman EJ,Russell AJ,Wagner WR

更新日期：1998-10-01 00:00:00

abstract：:In vitro protein adsorption, platelet adhesion and activation on new hydrogel surfaces, composed of poly(ethylene oxide) (PEO) and poly(tetramethylene oxide) (PTMO) or poly(dimethyl siloxane) (PDMS), were investigated. By varying PEO length (MW = 2000 or 3400), hydrophobic components (PTMO or PDMS) or polymer topology...

journal_title：Biomaterials

authors： Park JH,Bae YH

更新日期：2002-04-01 00:00:00

abstract：:Polyurethane microspheres having diameters in the range 150-1500 microns were prepared by condensation polymerization of toluene diisocyanate (TDI) with poly(tetramethylene glycol) (PTMG) of average mol wt 990 in an aqueous dispersion medium containing dioctyl sulphosuccinate (DOS) as the suspension stabilizer and 1,4...

journal_title：Biomaterials

authors： Thanoo BC,Sunny MC,Jayakrishnan A

更新日期：1991-07-01 00:00:00

abstract：:This study was designed to examine the adhesion, proliferation, and morphology of chondrocytes on new scaffolds; and to examine these cells histologically for the ability of the chondrocytes to maintain chondrogenic properties after subcutaneous implantation into nude mice. Both 75:25 poly (L-lactide-co-epsilon-caprol...

journal_title：Biomaterials

authors： Honda M,Morikawa N,Hata K,Yada T,Morita S,Ueda M,Kimata K

更新日期：2003-09-01 00:00:00

abstract：:The development of artificial microstructures suited for interfacing of peripheral nerves is not only relevant for basic neurophysiological research but also for future prosthetic approaches. Aim of the present study was to provide a detailed analysis of axonal sprouting and reactive tissue changes after implantation ...

journal_title：Biomaterials

authors： Klinge PM,Vafa MA,Brinker T,Brandis A,Walter GF,Stieglitz T,Samii M,Wewetzer K

更新日期：2001-09-01 00:00:00

abstract：:The incidence of Parkinson's disease (PD), the second most common neurodegenerative disorder, has increased exponentially as the global population continues to age. Although the etiological factors contributing to PD remain uncertain, its average incidence rate is reported to be 1% of the global population older than ...

journal_title：Biomaterials

authors： Karthivashan G,Ganesan P,Park SY,Lee HW,Choi DK

更新日期：2020-02-01 00:00:00