A review of the effects of the cell environment physicochemical nanoarchitecture on stem cell commitment.

abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

journal_title：Biomaterials

authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

更新日期：2011-10-01 00:00:00

abstract：:The carboxymethylcellulose-gelatine carrier system was investigated for invertase immobilization. Chromium (III) acetate, chromium (III) sulphate and potassium chromium (III) sulphate were used as cross-linking agents. Effect of carboxymethylcellulose-gelatine ratio and cross-linker concentration on immobilized enzyme...

journal_title：Biomaterials

authors： Emregül E,Sungur S,Akbulut U

更新日期：1996-07-01 00:00:00

abstract：:Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...

journal_title：Biomaterials

authors： Rampoldi A,Jha R,Fite J,Boland G,Xu C

更新日期：2021-01-11 00:00:00

abstract：:Riboflavin (Rf) and its metabolic analogs flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential for normal cellular growth and function. Their intracellular transport is regulated by the riboflavin carrier protein (RCP), which has been shown to be over-expressed by metabolically active cancer...

journal_title：Biomaterials

authors： Jayapaul J,Arns S,Lederle W,Lammers T,Comba P,Gätjens J,Kiessling F

更新日期：2012-12-01 00:00:00

abstract：:Nanoparticles have been widely used for delivering various chemical and biomolecular drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles have advantages of non-cytotoxicity and biodegradability. In this study, a recombinant 30Kc19 protein was applied to human serum alb...

journal_title：Biomaterials

authors： Lee HJ,Park HH,Kim JA,Park JH,Ryu J,Choi J,Lee J,Rhee WJ,Park TH

更新日期：2014-02-01 00:00:00

abstract：:The release of the anti-inflammatory agent dexamethasone (DEX) from nanoparticles of poly(lactic-co-glycolic acid) (PLGA) embedded in alginate hydrogel (HG) matrices was investigated. DEX-loaded PLGA nanoparticles were prepared using a solvent evaporation technique and were characterized for size, drug loading, and in...

journal_title：Biomaterials

authors： Kim DH,Martin DC

更新日期：2006-05-01 00:00:00

abstract：:When developed as targeting ligands for the in vivo delivery of biomaterials to biological systems, RNA aptamers immediately face numerous obstacles, in particular nuclease degradation and post-selection 2' modification. This study aims to develop a novel class of highly stable, 2'-fully modified RNA aptamers that are...

journal_title：Biomaterials

authors： Friedman AD,Kim D,Liu R

更新日期：2015-01-01 00:00:00

abstract：:Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...

journal_title：Biomaterials

authors： Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

更新日期：2012-05-01 00:00:00

abstract：:This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyrid...

journal_title：Biomaterials

authors： Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

更新日期：2003-09-01 00:00:00

abstract：:Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...

journal_title：Biomaterials

authors： Rowley JA,Madlambayan G,Mooney DJ

更新日期：1999-01-01 00:00:00

abstract：:Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt e...

journal_title：Biomaterials

authors： Loessner D,Rockstroh A,Shokoohmand A,Holzapfel BM,Wagner F,Baldwin J,Boxberg M,Schmalfeldt B,Lengyel E,Clements JA,Hutmacher DW

更新日期：2019-01-01 00:00:00

abstract：:MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics prob...

journal_title：Biomaterials

authors： Kim JK,Choi KJ,Lee M,Jo MH,Kim S

更新日期：2012-01-01 00:00:00

abstract：:In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be...

journal_title：Biomaterials

authors： Diarra M,Pourroy G,Muster D,Zingraff M,Boymond C

更新日期：1998-08-01 00:00:00

abstract：:Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the ...

journal_title：Biomaterials

authors： Grunkemeier JM,Tsai WB,McFarland CD,Horbett TA

更新日期：2000-11-01 00:00:00

abstract：:Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, a...

journal_title：Biomaterials

authors： Kobayashi K,Ichihara Y,Sato N,Umeda N,Fields L,Fukumitsu M,Tago Y,Ito T,Kainuma S,Podaru M,Lewis-McDougall F,Yamahara K,Uppal R,Suzuki K

更新日期：2019-07-01 00:00:00

abstract：:Calcium phosphate (CaP) based approaches remain an attractive option for delivering plasmid DNA (pDNA) into cultured cells. However, despite their appeal, current synthesis methodologies typically yield lower, less consistent transfection efficiencies when compared to viral approaches. Therefore, we report here a nove...

journal_title：Biomaterials

authors： Olton D,Li J,Wilson ME,Rogers T,Close J,Huang L,Kumta PN,Sfeir C

更新日期：2007-02-01 00:00:00

abstract：:Development of non-invasive assay for the accurate diagnosis of progressive liver diseases (e.g., fatty liver and hepatocellular carcinoma (HCC)) is of great clinical significance and remains to be a big challenge. Herein, we reported the synthesis of strawberry-like Fe3O4-Au hybrid nanoparticles at room temperature t...

journal_title：Biomaterials

authors： Zhao HY,Liu S,He J,Pan CC,Li H,Zhou ZY,Ding Y,Huo D,Hu Y

更新日期：2015-05-01 00:00:00

abstract：:Thin sheets of nanofibrous (NF) poly(L-lactic acid) (PLLA) matrix were fabricated using a novel phase separation method, mimicking the structure of natural collagen fibers. In this study, the cell morphology, cytoskeleton and adhesion structure, proliferation and differentiation were investigated on NF PLLA matrix usi...

journal_title：Biomaterials

authors： Hu J,Liu X,Ma PX

更新日期：2008-10-01 00:00:00

abstract：:Photodynamic therapy (PDT) induced hypoxia can significantly upregulate the expression of vascular endothelial growth factor (VEGF) at the tumor-stromal interface, resulting in a promoted angiogenesis. Thus, an angiogenesis vessel-targeting nanoparticle (AVT-NP) consisting of photosensitizer, angiogenic vessel-targeti...

journal_title：Biomaterials

authors： Guo D,Xu S,Wang N,Jiang H,Huang Y,Jin X,Xue B,Zhang C,Zhu X

更新日期：2017-11-01 00:00:00

abstract：:The kinetics of thrombin inhibition by antithrombin (AT) and heparin cofactor II (HC II) were analysed as a function of the heparin concentration, from 10(-9) to 10(-4) M. The initial concentrations of inhibitor (l) and thrombin (E) were set at equimolar levels (CI = CE = 10(-8) M). The experimental data indicate that...

journal_title：Biomaterials

authors： Maaroufi RM,Jozefowicz M,Tapon-Bretaudière J,Fischer AM

更新日期：1997-02-01 00:00:00

abstract：:One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However, there have been no controlled studies to investigate the influence of skeletal maturity on the MSC-based repair of cartilage. The purpose of this study was to compare the ...

journal_title：Biomaterials

authors： Shimomura K,Ando W,Tateishi K,Nansai R,Fujie H,Hart DA,Kohda H,Kita K,Kanamoto T,Mae T,Nakata K,Shino K,Yoshikawa H,Nakamura N

更新日期：2010-11-01 00:00:00

abstract：:IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its ap...

journal_title：Biomaterials

authors： Yue C,Liu P,Zheng M,Zhao P,Wang Y,Ma Y,Cai L

更新日期：2013-09-01 00:00:00

abstract：:We report the synthesis and characterization of dendrimer-entrapped gold nanoparticles (Au DENPs) modified by polyethylene glycol (PEG) with enhanced biocompatibility for computed tomography (CT) imaging applications. In this study, amine-terminated poly(amidoamine) dendrimers of generation 5 (G5.NH(2)) modified by PE...

journal_title：Biomaterials

authors： Peng C,Zheng L,Chen Q,Shen M,Guo R,Wang H,Cao X,Zhang G,Shi X

更新日期：2012-02-01 00:00:00

abstract：:The effects of chitin [(1 --> 4)-2-acetamido-2-deoxy-beta-D-glucan] and its partially deacetylated derivatives, chitosans, on the proliferation of human dermal fibroblasts and keratinocytes were examined in vitro. Chitosans with relatively high degrees of deacetylation strongly stimulated fibroblast proliferation whil...

journal_title：Biomaterials

authors： Howling GI,Dettmar PW,Goddard PA,Hampson FC,Dornish M,Wood EJ

更新日期：2001-11-01 00:00:00

abstract：:The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By ble...

journal_title：Biomaterials

authors： Ji J,Zhu H,Shen J

更新日期：2004-05-01 00:00:00

abstract：:Both positively and negatively charged residues play pivotal roles in recruiting precursor ions or ion clusters, and lowering interfacial energy in natural biomineralization process. Synergistic utilization of opposite charges, however, has rarely been implemented in the design of cytocompatible synthetic scaffolds pr...

journal_title：Biomaterials

authors： Liu P,Song J

更新日期：2013-03-01 00:00:00

abstract：:Hydroxyapatite (HA) in 25%, 50% and 75% w/w fractions was incorporated into chitin solutions and processed into air- and freeze-dried materials. These HA-chitin materials were exposed to cell cultures and implanted into the intramusculature of a rat model. The HA-chitin materials were found to be non-cytotoxic and deg...

journal_title：Biomaterials

authors： Ge Z,Baguenard S,Lim LY,Wee A,Khor E

更新日期：2004-03-01 00:00:00

abstract：:Silicon (Si) substitution in the crystal structures of calcium phosphate (CaP) ceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP) generates materials with superior biological performance to stoichiometric counterparts. Si, an essential trace element required for healthy bone and connective tissues, in...

journal_title：Biomaterials

authors： Pietak AM,Reid JW,Stott MJ,Sayer M

更新日期：2007-10-01 00:00:00

abstract：:Intercellular interactions in the cell microenvironment play a critical role in determining cell fate, but the effects of these interactions on pathways governing human embryonic stem cell (hESC) behavior have not been fully elucidated. We and others have previously reported that 3-D culture of hESCs affects cell fate...

journal_title：Biomaterials

authors： Azarin SM,Lian X,Larson EA,Popelka HM,de Pablo JJ,Palecek SP

更新日期：2012-03-01 00:00:00

abstract：:Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradat...

journal_title：Biomaterials

authors： Ma C,Gerhard E,Lu D,Yang J

更新日期：2018-09-01 00:00:00