当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > In vivo cell recruitment, cytokine release and chemiluminescence response at gold, and thiol functionalized surfaces.

In vivo cell recruitment, cytokine release and chemiluminescence response at gold, and thiol functionalized surfaces.

Abstract：

:Hydroxylated and methylated surfaces were prepared by the self-assembled monolayer technique (SAM) of alkane thiols on gold. The surfaces were used to evaluate the influence of implant surface chemistry on protein deposition and inflammatory cell response. Implants were inserted subcutaneously in the rat for 3 and 24 h. The surface chemical properties influenced the in vitro rat plasma protein adsorption (ellipsometry/antibody) with few exceptions (albumin not found and fibrinogen always found). The number of recruited cells and their distribution (DNA from implant versus from exudate) was influenced by the different chemistries at 24 h, but not at 3 h. HIS48+, ED1+, ED2+ and small numbers of CD5+ cells were present in the exudate at both time periods (flow cytometry). The cellular oxidative metabolism was low, although cells on -OH surfaces responded with the highest phorbol ester-stimulated chemiluminescence (CL)/DNA. The levels of cytokines IL-1alpha, IL-1beta and TNFalpha (ELISA) were not influenced by material surface chemistry. Sham operated sites had a higher cytokine concentration/DNA compared with exudates from an implant milieu. The results of this study show that surface chemical functionalization modifies specific events in the inflammatory response around implants in soft tissues.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Källtorp M,Oblogina S,Jacobsson S,Karlsson A,Tengvall P,Thomsen P

doi

10.1016/s0142-9612(99)00115-5

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

2123-37

issue

22

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(99)00115-5

journal_volume

20

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Differential characterization of hepatic tumors in MR imaging by burst-released Mn2+-ions from hollow manganese-silicate nanoparticles in the liver.

    abstract：:Gd3+-based contrast agents monopolize in the clinical MR imaging-based diagnosis of hepatic tumors, however, the inherent toxicity by the released Gd3+-ions triggered an urgent demand for safer alternatives. Here, we demonstrate hollow manganese silicate nanoparticles (HMS), which exert burst-release of Mn2+-ions by s...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.119600

    authors： Kim JG,Jang MS,Kumari N,Choi JK,Im GH,Kwon T,Lee JH,Lee WJ,Lee IS

    更新日期：2020-02-01 00:00:00

  • The promotion of neural progenitor cells proliferation by aligned and randomly oriented collagen nanofibers through β1 integrin/MAPK signaling pathway.

    abstract：:In regenerative medicine, accumulating evidence demonstrates that the property of substrates monitors neural stem cells behavior. However, how stem cells sense and interpret biochemical and topographical cues remains elusive. This study aimed to explore the mechanism how nanofibrous scaffold modulated stem cells behav...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.05.075

    authors： Wang Y,Yao M,Zhou J,Zheng W,Zhou C,Dong D,Liu Y,Teng Z,Jiang Y,Wei G,Cui X

    更新日期：2011-10-01 00:00:00

  • Contractile behavior of smooth muscle actin-containing osteoblasts in collagen-GAG matrices in vitro: implant-related cell contraction.

    abstract：:The contraction of connective tissue cells may facilitate their production and maintenance of extracellular matrix architecture and can benefit healing through wound closure. However, aberrant cell contraction can result in pathological contracture. Implants may stimulate this process leading to contracture of the sur...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00062-4

    authors： Menard C,Mitchell S,Spector M

    更新日期：2000-09-01 00:00:00

  • The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotype.

    abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.08.004

    authors： Beamish JA,Geyer LC,Haq-Siddiqi NA,Kottke-Marchant K,Marchant RE

    更新日期：2009-10-01 00:00:00

  • An injectable conductive hydrogel encapsulating plasmid DNA-eNOs and ADSCs for treating myocardial infarction.

    abstract：:Myocardial infarction (MI) leads to the mass death of cardiomyocytes accompanying with the unfavorable alternation of microenvironment, a fibrosis scar deprived of electrical communications, and the lack of blood supply in the infarcted myocardium. The three factors are inextricably intertwined and thus result in a co...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.01.021

    authors： Wang W,Tan B,Chen J,Bao R,Zhang X,Liang S,Shang Y,Liang W,Cui Y,Fan G,Jia H,Liu W

    更新日期：2018-04-01 00:00:00

  • Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo.

    abstract：:Resistance to platinum agents is challenging in cancer treatment with platinum drugs. Such resistant cells prevent effective platinum accumulation intracellular and alter cellular adaptations to survive from cytotoxicity by regulating corresponding proteins expression. Ideal therapeutics should combine resolution to t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.11.014

    authors： Yu C,Ding B,Zhang X,Deng X,Deng K,Cheng Z,Xing B,Jin D,Ma P,Lin J

    更新日期：2018-02-01 00:00:00

  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern.

    abstract：:The physiological activity of hyaluronic acid (HA) polymers and oligomers makes it a promising material for a variety of applications. The development of HA-hydrogel scaffolds with improved mechanical stability against degradation and biochemical functionality may enhance their application to tissue engineering. In th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.02.067

    authors： Segura T,Anderson BC,Chung PH,Webber RE,Shull KR,Shea LD

    更新日期：2005-02-01 00:00:00

  • Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin.

    abstract：:pH-triggered lipid-membranes designed from biophysical principles are evaluated in the form of targeted liposomal doxorubicin with the aim to ultimately better control the growth of vascularized tumors. We compare the antitumor efficacy of anti-HER2/neu pH-triggered lipid vesicles encapsulating doxorubicin to the anti...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.02.039

    authors： Bandekar A,Karve S,Chang MY,Mu Q,Rotolo J,Sofou S

    更新日期：2012-06-01 00:00:00

  • MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates.

    abstract：:Microbial polyhydroxyalkanoates (PHA) including poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) were found to induce chondrogenesis of mesenchymal stem cells (MSCs) and preserve chondrocytic phenotype as well as support chondrocytes-specific extracellular matrix (ECM) secretion. In this study, mouse MSCs cultur...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.05.031

    authors： Yan C,Wang Y,Shen XY,Yang G,Jian J,Wang HS,Chen GQ,Wu Q

    更新日期：2011-09-01 00:00:00

  • 'Dual' peptidyl-oligonucleotide conjugates: Role of conformational flexibility in catalytic cleavage of RNA.

    abstract：:Traditional therapeutic interventions against abnormal gene expression in disease states at the level of expressed proteins are becoming increasingly difficult due to poor selectivity, off-target effects and associated toxicity. Upstream catalytic targeting of specific RNA sequences offers an alternative platform for ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.09.033

    authors： Staroseletz Y,Williams A,Burusco KK,Alibay I,Vlassov VV,Zenkova MA,Bichenkova EV

    更新日期：2017-01-01 00:00:00

  • The glass ionomer cement: the sources of soluble fluoride.

    abstract：:This study aimed to investigate certain processes of fluoride production which enable glass ionomer cements to leach fluoride. Two fluoroaluminosilicate glasses, G338 and LG26 were used. The free and total fluoride which could be dissolved from the glasses was measured, before and after acetic acid washing. Both glass...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00352-0

    authors： Williams JA,Billington RW,Pearson GJ

    更新日期：2002-05-01 00:00:00

  • Development of a soft tissue seal around bone-anchored transcutaneous amputation prostheses.

    abstract：:Conventional amputation prosthetics are problematic because they rely on the stump-socket interface for attachment. Intraosseous transcutaneous amputation prostheses (ITAP) could solve these problems; however they rely on the integrity of the soft tissue-implant interface as a barrier to exogenous agents, and in the p...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.03.041

    authors： Pendegrass CJ,Goodship AE,Blunn GW

    更新日期：2006-08-01 00:00:00

  • Crack propagation in conventional and high copper dental amalgam as a function of strain rate.

    abstract：:Dental amalgam prepared from high copper and conventional alloys was evaluated for its compressive strength as a function of deformation rate. Results showed that the compressive strength rose to a maximum as deformation rate increased and then began to fall at higher deformation rates. Crack propagation predominated ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(86)90046-3

    authors： Zardiackas LD,Anderson L Jr

    更新日期：1986-07-01 00:00:00

  • Local variation in the tearing strength of chemically modified pericardium.

    abstract：:Forty squares of tissue, 40 mm X 40 mm, were harvested from bovine pericardium fixed in glutaraldehyde free of tension. Two parallel dumb-bell specimens were excised from each square. In 20 pairs of adjacent samples, two 1 mm cuts were introduced into one of the samples at the centre of the dumb-bell. The other 20 pai...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(89)90098-7

    authors： Crofts CE,Trowbridge EA

    更新日期：1989-05-01 00:00:00

  • Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer.

    abstract：:Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of solid carcinomas confined within the peritoneal cavity, with potential benefits in locoregional and systemic management of residual tumors. In this study, we intended to increase local retention of platinum in the peritoneal cavity over a prolon...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.10.039

    authors： Cho EJ,Sun B,Doh KO,Wilson EM,Torregrosa-Allen S,Elzey BD,Yeo Y

    更新日期：2015-01-01 00:00:00

  • Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection.

    abstract：:Developing materials that are effective against sexually transmitted pathogens such as Chlamydia trachomatis (Ct) and HIV-1 is challenging both in terms of material selection and improving bio-membrane and cellular permeability at desired mucosal sites. Here, we engineered the prokaryotic bacterial virus (M13 phage) c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.03.054

    authors： Bhattarai SR,Yoo SY,Lee SW,Dean D

    更新日期：2012-07-01 00:00:00

  • Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs.

    abstract：:Most part of pH- and temperature-sensitive microspheres used for the controlled delivery of drugs are not biodegradable. Therefore, the aim of this work is to prepare pH- and temperature-sensitive microspheres from biodegradable and biocompatible natural polymers. Pullulan microspheres were prepared by suspension cros...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.03.025

    authors： Fundueanu G,Constantin M,Ascenzi P

    更新日期：2008-06-01 00:00:00

  • Dual-role self-assembling nanoplexes for efficient gene transfection and sustained gene delivery.

    abstract：:Novel cationic pentablock copolymers with poly(diethylamino ethyl methacrylate) blocks covalently attached to parent triblock Pluronic copolymers have been designed and developed as sustained release non-viral gene delivery vectors. These copolymers electrostatically condense plasmid DNA into nanostructures (nanoplexe...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2007.10.010

    authors： Agarwal A,Unfer RC,Mallapragada SK

    更新日期：2008-02-01 00:00:00

  • Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles.

    abstract：:TRAIL has received considerable attention as a potential anti-cancer agent due to its specific ability to target tumors. However, recombinant TRAIL has several limitations, such as, its short biological half-life, its inherent instability, and its potential hepatotoxicity. In this study, we developed a sustained relea...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.01.054

    authors： Lim SM,Kim TH,Jiang HH,Park CW,Lee S,Chen X,Lee KC

    更新日期：2011-05-01 00:00:00

  • The synovial response to intra-articular acrylic cement particles in guinea pigs.

    abstract：:The histology and cytology of the tissue response to intra-articular insertion of particles of acrylic bone cement containing barium sulphate has been studied in the guinea pig knee joint. Following insertion of the acrylic, fibrinous debris admixed with particles became adherent to the synovial membrane. Cell prolife...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(84)90003-6

    authors： Meachim G,Brooke G

    更新日期：1984-03-01 00:00:00

  • Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate.

    abstract：:In the cellular microenvironment, growth factor gradients are crucial in dictating cell fate. Towards developing materials that capture the native microenvironment we engineered biomimetic films that present gradients of matrix-bound bone morphogenetic proteins (BMP-2 and BMP-7). To this end layer-by-layer films compo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.01.012

    authors： Almodóvar J,Guillot R,Monge C,Vollaire J,Selimović S,Coll JL,Khademhosseini A,Picart C

    更新日期：2014-04-01 00:00:00

  • Creep in a palladium-enriched high-copper amalgam.

    abstract：:Palladium additions to a dispersed phase high-copper amalgam have been shown recently to suppress markedly the eta' (Cu6Sn5) concentration and decrease creep. A detailed study of the dental and 24 h creep for Pd containing high-copper amalgams and six commercial controls as a function of applied temperature and stress...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(88)90086-5

    authors： Greener EH,Chung KH,Lin JH

    更新日期：1988-05-01 00:00:00

  • The role of physiological mechanical cues on mesenchymal stem cell differentiation in an airway tract-like dense collagen-silk fibroin construct.

    abstract：:Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airwa...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.04.040

    authors： Ghezzi CE,Marelli B,Donelli I,Alessandrino A,Freddi G,Nazhat SN

    更新日期：2014-08-01 00:00:00

  • The effect of spacer arm length of an adhesion ligand coupled to an alginate gel on the control of fibroblast phenotype.

    abstract：:Tissue engineering requires the use of polymeric scaffolds that mimic many roles of extracellular matrices (ECM) in the body. Controlling cell-scaffold interactions is one of the most critical parameters for regulating cell phenotype in tissue engineering, and a peptide with the sequence of RGD has been widely exploit...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.03.063

    authors： Lee JW,Park YJ,Lee SJ,Lee SK,Lee KY

    更新日期：2010-07-01 00:00:00

  • Preparation of EVAL membranes with smooth and particulate morphologies for neuronal culture.

    abstract：:In this work, the in vitro interaction of cerebellar granule neurons prepared from 7-day-old Wistar rats and poly ethylene-co-vinyl alcohol (EVAL) membranes was investigated. Cells were cultured in smooth and particulate EVAL membranes for up to 7 days. Particulate membranes were prepared by using 1-octanol to precipi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00337-9

    authors： Young TH,Lin CW,Cheng LP,Hsieh CC

    更新日期：2001-07-01 00:00:00

  • In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles: mechanisms, key factors, and their implications.

    abstract：:The development of more selective delivery systems for cancer diagnosis and chemotherapy is one of the most important goals of current anticancer research. The purpose of this study is to evaluate various self-assembled nanoparticles as candidates to shuttle radionuclide and/or drugs into tumors and to investigate the...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.10.002

    authors： Cho YW,Park SA,Han TH,Son DH,Park JS,Oh SJ,Moon DH,Cho KJ,Ahn CH,Byun Y,Kim IS,Kwon IC,Kim SY

    更新日期：2007-02-01 00:00:00

  • Relationships between degradability of silk scaffolds and osteogenesis.

    abstract：:Bone repairs represent a major focus in orthopedic medicine with biomaterials as a critical aspect of the regenerative process. However, only a limited set of biomaterials are utilized today and few studies relate biomaterial scaffold design to degradation rate and new bone formation. Matching biomaterial remodeling r...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.04.028

    authors： Park SH,Gil ES,Kim HJ,Lee K,Kaplan DL

    更新日期：2010-08-01 00:00:00

  • Iodine-containing cellulose mixed esters as radiopaque polymers for direct embolization of cerebral aneurysms and arteriovenous malformations.

    abstract：:The present study deals with the synthesis and characterization of radiopaque polymers which could, when solubilized in an appropriate water-miscible solvent, be useful embolic materials for the treatment of cerebral aneurysms and arteriovenous malformations. For this purpose cellulose (both microcrystalline and powde...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00087-4

    authors： Mottu F,Rüfenacht DA,Laurent A,Doelker E

    更新日期：2002-01-01 00:00:00

  • Autoclavable highly cross-linked polyurethane networks in ophthalmology.

    abstract：:Highly cross-linked aliphatic polyurethane networks have been prepared by the bulk step reaction of low molecular weight polyols and hexamethylenediisocyanate (HDI). These polyurethane networks are optically transparent, colourless and autoclavable amorphous glassy thermosets, which are suited for use in ophthalmic ap...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(93)90210-s

    authors： Bruin P,Meeuwsen EA,van Andel MV,Worst JG,Pennings AJ

    更新日期：1993-11-01 00:00:00

  • pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride.

    abstract：:pH-sensitive degradable chimaeric polymersomes were developed based on asymmetric poly(ethylene glycol)-b-poly(2,4,6-trimethoxybenzylidene-1,1,1-tris(hydroxymethyl)ethane methacrylate)-b-poly(acrylic acid) (PEG-PTTMA-PAA) triblock copolymers for active loading as well as triggered intracellular release of hydrophilic ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.06.034

    authors： Du Y,Chen W,Zheng M,Meng F,Zhong Z

    更新日期：2012-10-01 00:00:00