Abstract：
:Periosteal derived bovine osteoblast-like cells migrated in culture onto an ionomeric cement. Cell cultures were maintained for 4 weeks and used to study the in vitro behaviour of cells on the ionomeric bone cement (IC). The cells produced bone matrix proteins (osteocalcin, bone sialoprotein II) and were osteoblast-like. The osteoblast-like cells colonized the substrate in monolayers and produced an extracellular matrix as seen by light and scanning electron microscopy. Morphological comparison between cells growing on the ionomeric bone cement and cortical bone revealed no significant difference in phenotypic expression. Staining for aluminium in osteoblasts growing on the IC showed an uptake and storage of aluminium in the cells. Energy dispersive X-ray microanalysis revealed high concentrations of aluminium and silicon in the periosteal tissue. Despite the known toxic effect of aluminium in vivo and in vitro on osteoblasts, no signs of toxicity were apparent on light and scanning electron microscopy analysis.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Meyer U,Szulczewski DH,Barckhaus RH,Atkinson M,Jones DBdoi
10.1016/0142-9612(93)90133-msubject
Has Abstractpub_date
1993-10-01 00:00:00pages
917-24issue
12eissn
0142-9612issn
1878-5905pii
0142-9612(93)90133-Mjournal_volume
14pub_type
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