Static and dynamic in vitro study of a sol-gel glass bioactivity.

abstract：:Compared to soluble cytokines, surface-tethered ligands can deliver biological signalling with precise control of spatial positioning and concentration. A strategy that immobilises ligand molecules on a surface in a uniform orientation using non-cleavable linkages under physiological conditions would enhance the speci...

journal_title：Biomaterials

authors： Lee EJ,Be CL,Vinson AR,Riches AG,Fehr F,Gardiner J,Gengenbach TR,Winkler DA,Haylock D

更新日期：2015-01-01 00:00:00

abstract：:Chemotherapeutic agents often cause severe side effects because they produce a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both tumor microenvironment-sensitive polypeptides (TMSP) and folate to create a more selecti...

journal_title：Biomaterials

authors： Gao W,Xiang B,Meng TT,Liu F,Qi XR

更新日期：2013-05-01 00:00:00

abstract：:Thermosensitive "micellar hydrogel" is prepared based on poly(ε-caprolactone-co- 1,4,8-trioxa[4.6]spiro-9-undecanone)-b-poly(ethylene glycol)- b-poly(ε-caprolactone- co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) triblock copolymer. Fluorescence resonance energy transfer (FRET) is adopted to explore its assembly (form...

journal_title：Biomaterials

authors： Huang P,Song H,Zhang Y,Liu J,Cheng Z,Liang XJ,Wang W,Kong D,Liu J

更新日期：2017-11-01 00:00:00

abstract：:In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be...

journal_title：Biomaterials

authors： Diarra M,Pourroy G,Muster D,Zingraff M,Boymond C

更新日期：1998-08-01 00:00:00

abstract：:Suture materials may interact with immune competent cells and thereby affect localized immunity. Macrophages are central to the inflammatory response and coordinate wound healing. They are also involved in the clearance of foreign material, bacteria and malignant cells. We studied the influence of soluble factors asso...

journal_title：Biomaterials

authors： Uff CR,Scott AD,Pockley AG,Phillips RK

更新日期：1995-03-01 00:00:00

abstract：:The ability to influence the direction of polymerization of a self-assembling biomolecular system has the potential to generate materials with extremely high anisotropy. In biological systems where highly-oriented cellular populations give rise to aligned and often load-bearing tissue such organized molecular scaffold...

journal_title：Biomaterials

authors： Saeidi N,Sander EA,Ruberti JW

更新日期：2009-12-01 00:00:00

abstract：:We genetically introduced the Fc-binding peptide (FcBP) into the loop of a self-assembled protein cage, ferritin, constituting four-fold symmetry at the surface to use it as a modular delivery nanoplatform. FcBP-presenting ferritin (FcBP-ferritin) formed very stable non-covalent complexes with both human and rabbit Ig...

journal_title：Biomaterials

authors： Kang HJ,Kang YJ,Lee YM,Shin HH,Chung SJ,Kang S

更新日期：2012-07-01 00:00:00

abstract：:Cell attachment, proliferation and differentiation on different materials depend largely on the surface properties of the materials. This study sheds light on the mechanism by which the modulation of the chemical composition of calcium silicate cements with different Si/Ca molar ratios could produce different cell res...

journal_title：Biomaterials

authors： Shie MY,Ding SJ

更新日期：2013-09-01 00:00:00

abstract：:Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated HSCs, which are the main contributors to liver fibrosis. Hence, a strategy for regulating HSC activation is important in the trea...

journal_title：Biomaterials

authors： Wang S,Kim J,Lee C,Oh D,Han J,Kim TJ,Kim SW,Seo YS,Oh SH,Jung Y

更新日期：2019-10-01 00:00:00

abstract：:Atherosclerosis is the leading cause of many fatal cardiovascular and cerebrovascular diseases. Whereas nanomedicines are promising for targeted therapy of atherosclerosis, great challenges remain in development of effective, safe, and translational nanotherapies for its treatment. Herein we hypothesize that non-proin...

journal_title：Biomaterials

authors： Dou Y,Chen Y,Zhang X,Xu X,Chen Y,Guo J,Zhang D,Wang R,Li X,Zhang J

更新日期：2017-10-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are promising cell sources for cell-based therapy. It has been established that the formation of ESC aggregates promotes their differentiation into the derivatives of all three germ layers. ESC aggregates are generally prepared via the formation of suspended spherical aggregates called embr...

journal_title：Biomaterials

authors： Sasaki D,Shimizu T,Masuda S,Kobayashi J,Itoga K,Tsuda Y,Yamashita JK,Yamato M,Okano T

更新日期：2009-09-01 00:00:00

abstract：:Although PEGylated liposome-based drug delivery systems hold great promising applications for cancer therapy due to their prolonged blood circulation time, PEGylation significantly reduces their cellular uptake, which markedly impairs the in vivo tumor retention and antitumor efficiency of drug-loaded liposomes. Most ...

journal_title：Biomaterials

authors： Li Y,Liu R,Yang J,Shi Y,Ma G,Zhang Z,Zhang X

更新日期：2015-02-01 00:00:00

abstract：:X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2O3 (BP/Bi2O3) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer ...

journal_title：Biomaterials

authors： Huang H,He L,Zhou W,Qu G,Wang J,Yang N,Gao J,Chen T,Chu PK,Yu XF

更新日期：2018-07-01 00:00:00

abstract：:In vitro experiments were conducted upon some common metallic biomaterials and carbons, both isolated or forming galvanic couples, in a cell specially designed for crevice corrosion studies. The alloys examined were AISI 316L stainless steel, Ti6AI4V and Co-Cr-Mo. The types of carbon were glassy carbon and carbon fibr...

journal_title：Biomaterials

authors： Silva RA,Barbosa MA,Jenkins GM,Sutherland I

更新日期：1990-07-01 00:00:00

abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...

journal_title：Biomaterials

authors： Matsuda K,Suzuki S,Isshiki N,Ikada Y

更新日期：1993-10-01 00:00:00

abstract：:We present a new ultrasonic technique for monitoring the entire setting process of injectable bone cement. The problem with existing standards is their subjectivity. Because of this the results are not comparable between different research groups. A strong advantage with the proposed technique is that it is non-invasi...

journal_title：Biomaterials

authors： Carlson J,Nilsson M,Fernández E,Planell JA

更新日期：2003-01-01 00:00:00

abstract：:Polystyrene and phenylated polyacrolein microspheres of different diameters, as well as modified cellulose microspheres with different surface charges, were prepared in order to study the size and surface charge effect on their phagocytosis by mouse peritoneal macrophages. It was found that the maximal phagocytosis of...

journal_title：Biomaterials

authors： Tabata Y,Ikada Y

更新日期：1988-07-01 00:00:00

abstract：:Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully design...

journal_title：Biomaterials

authors： Liang X,Fang L,Li X,Zhang X,Wang F

更新日期：2017-07-01 00:00:00

abstract：:An independent assessment was performed of the results of woven carbon implants of mesh or rods into articular cartilage defects performed by two surgeons in the knees of 96 patients. Eight had symptomatic osteochondritis, 31 had chondromalacia patellae and 57 had early osteoarthritis. They were reviewed up to 5 yr af...

journal_title：Biomaterials

authors： Pongor P,Betts J,Muckle DS,Bentley G

更新日期：1992-01-01 00:00:00

abstract：:Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...

journal_title：Biomaterials

authors： Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

更新日期：2010-09-01 00:00:00

abstract：:The thermally responsive cholesteryl end-capped poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and cholesteryl grafted poly[N-isopropylacrylamide-co-N-(hydroxymethyl) acrylamide] amphiphilic polymers were synthesized and utilized to encapsulate cyclosporin A (CyA) and indomethacin (IND) within core-shell nanopa...

journal_title：Biomaterials

authors： Chaw CS,Chooi KW,Liu XM,Tan CW,Wang L,Yang YY

更新日期：2004-08-01 00:00:00

abstract：:Two types of cells--human platelets and spore cells--were encapsulated in polymer shells by adsorbing polyanions and polycations in a stepwise fashion. The encapsulated cells were attached to gold and silicon surfaces and their morphological and adhesion properties were studied in air using tapping mode atomic force m...

journal_title：Biomaterials

authors： Yu M,Ivanisevic A

更新日期：2004-08-01 00:00:00

abstract：:Dextran T40 was modified with carboxylic, benzylamide and benzylamine-sulphonated groups (samples 1-10). The polymers were incubated with dextranase and the decrease of molecular weight was determined by high performance size exclusion chromatography. It was shown that the higher the substitution of dextrans, the lowe...

journal_title：Biomaterials

authors： Crepon B,Jozefonvicz J,Chytry V,Rihová B,Kopecek J

更新日期：1991-08-01 00:00:00

abstract：:Pancreatic cancer has the worst prognosis of all cancers due to disease aggressiveness and paucity of early detection platforms. We developed biomaterial scaffolds that recruit metastatic tumor cells and reflect the immune dysregulation of native metastatic sites. While this platform has shown promise in orthotopic br...

journal_title：Biomaterials

authors： Bushnell GG,Orbach SM,Ma JA,Crawford HC,Wicha MS,Jeruss JS,Shea LD

更新日期：2020-12-23 00:00:00

abstract：:Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...

journal_title：Biomaterials

authors： Rowley JA,Madlambayan G,Mooney DJ

更新日期：1999-01-01 00:00:00

abstract：:We report on the fabrication of multifunctional polymeric unimolecular micelles as an integrated platform for cancer targeted drug delivery and magnetic resonance imaging (MRI) contrast enhancement under in vitro and in vivo conditions. Starting from a fractionated fourth-generation hyperbranched polyester (Boltorn H4...

journal_title：Biomaterials

authors： Li X,Qian Y,Liu T,Hu X,Zhang G,You Y,Liu S

更新日期：2011-09-01 00:00:00

abstract：:Combinations of calcium phosphate scaffolds and bioactive factors are promising niche-mimetic solutions for repairing large-sized bone defects. However, the importance of compatibility between scaffolds and bioactive factors on their osteogenic outcomes has been largely ignored. This study aimed to investigate the com...

journal_title：Biomaterials

authors： Zhang X,Xu M,Song L,Wei Y,Lin Y,Liu W,Heng BC,Peng H,Wang Y,Deng X

更新日期：2013-12-01 00:00:00

abstract：:Lymphocytes typically interact with implanted biomaterials through adsorbed exogenous proteins. To provide a more complete characterization of these interactions, analysis of lymphocyte migration on adsorbed extracellular matrix proteins must accompany the commonly performed adhesion studies. We report here a comparis...

journal_title：Biomaterials

authors： Bergman AJ,Zygourakis K

更新日期：1999-12-01 00:00:00

abstract：:Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...

journal_title：Biomaterials

authors： Rokkanen PU,Böstman O,Hirvensalo E,Mäkelä EA,Partio EK,Pätiälä H,Vainionpää SI,Vihtonen K,Törmälä P

更新日期：2000-12-01 00:00:00

abstract：:The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxy-substituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovin...

journal_title：Biomaterials

authors： Neenan TX,Allcock HR

更新日期：1982-04-01 00:00:00