Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy.

Abstract:

:X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2O3 (BP/Bi2O3) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2O3 nanoparticles onto BP nanosheets. The Bi2O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2O3 enable 1O2 overproduction under X-ray irradiation. This X-ray-PDT effect of the BP/Bi2O3 nanosheets enhances the radiotherapy activity towards cancer cells by inducing cell apoptosis and cycle arrest. In vivo treatment of melanoma conducted on a clinical radiotherapeutic instrument demonstrates that the BP/Bi2O3 sensitized radiotherapy inhibits tumor growth efficiently. Furthermore, the BP/Bi2O3 nanosheets composed of biological friendly P, O, and Bi elements shows good biocompatibility in vitro and in vivo. This radiosensitizer thus has immense clinical potential for cancer therapy, and our findings reveal a general strategy to fabricate stable BP-based heterostructures for different applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Huang H,He L,Zhou W,Qu G,Wang J,Yang N,Gao J,Chen T,Chu PK,Yu XF

doi

10.1016/j.biomaterials.2018.04.022

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

12-22

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(18)30278-3

journal_volume

171

pub_type

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