Abstract:
:Arterial catheterization is one of the most frequently performed inpatient diagnostic and therapeutic procedures in the development countries. Complications may occur after any catheterization from inadequate hemostasis, particularly in the setting of aggressive anticoagulation. This study suggests that microcrystalline chitosan (MCCh) sealant installation via an arterial sheath at the completion of catheterization may improve hemostasis. Results using MCCh in eight heparinized dogs documented significant reductions in manual compression time (P = 0.016) of the artery after withdrawal of both the sheath introducer and catheter. Comparative results were found in rats, wherein a created wound in the aorta could be sealed relatively quickly and easily. The biodegradability, optimalization, and a better pharmaceutical formulation of this potential hemostatic agent require further studies.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Hoekstra A,Struszczyk H,Kivekäs Odoi
10.1016/s0142-9612(98)00060-xsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
1467-71issue
16eissn
0142-9612issn
1878-5905pii
S0142-9612(98)00060-Xjournal_volume
19pub_type
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