Novel angiogenesis therapeutics by redox injectable hydrogel - Regulation of local nitric oxide generation for effective cardiovascular therapy.

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that affects more than 1 million individuals in the USA. Local therapy with enema formulations, such as micronized budesonide (Entocort®), is a common strategy for treating patients with distally active IBD. However, we hypothesize th...

journal_title：Biomaterials

authors： Date AA,Halpert G,Babu T,Ortiz J,Kanvinde P,Dimitrion P,Narayan J,Zierden H,Betageri K,Musmanno O,Wiegand H,Huang X,Gumber S,Hanes J,Ensign LM

更新日期：2018-12-01 00:00:00

abstract：:Novel collagen scaffolds possessing predefined and reproducible internal channels with widths of 135 microm and greater have been produced. The process employed to make the collagen scaffold utilises a sacrificial mould, manufactured using solid freeform fabrication technology, and critical point drying technique. A c...

journal_title：Biomaterials

authors： Sachlos E,Reis N,Ainsley C,Derby B,Czernuszka JT

更新日期：2003-04-01 00:00:00

abstract：:We demonstrate the ability of immobilized vascular endothelial growth factor (VEGF) to capture endothelial cells (EC) with high specificity under fluid flow. To this end, we engineered a surface consisting of heparin bound to poly-l-lysine to permit immobilization of VEGF through the C-terminal heparin-binding domain....

journal_title：Biomaterials

authors： Smith RJ Jr,Koobatian MT,Shahini A,Swartz DD,Andreadis ST

更新日期：2015-05-01 00:00:00

abstract：:Dibutyryl chitin (DBC) is a modified chitin carrying butyryl groups at 3 and 6 positions; its peculiarity is that it dissolves promptly in common solvents, while being insoluble in aqueous systems. The high biocompatibility of dibutyryl chitin in the form of films and non-wovens has been demonstrated for human, chick ...

journal_title：Biomaterials

authors： Muzzarelli RA,Guerrieri M,Goteri G,Muzzarelli C,Armeni T,Ghiselli R,Cornelissen M

更新日期：2005-10-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:The stabilities of two types of polymerically stabilized liposomes consisting of PEG-grafted (DSPC:CHOL:DSPE-PEG1900, 5:4:1) and physically adsorbed carboxymethylchitin (CMC) and carboxymethyl/glycolchitin (CO) are compared. The polyelectrolyte is adsorbed on positive (DSPC:CHOL:DMTAP, 5:4:1) and neutral (DSPC:CHOL, 1...

journal_title：Biomaterials

authors： Mobed M,Chang TM

更新日期：1998-07-01 00:00:00

abstract：:This study is aimed to develop a long-acting injectable formulation in treatment of type II diabetes. A glucoregulatory polypeptide, exenatide (EXT), was chosen as the model drug, and an aqueous block copolymer system with a sol-gel transition upon the increase of temperature was selected as the delivery matrix of EXT...

journal_title：Biomaterials

authors： Li K,Yu L,Liu X,Chen C,Chen Q,Ding J

更新日期：2013-04-01 00:00:00

abstract：:Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters which regulate paracellular and transcellular permeability. However, most existing models of BBB m...

journal_title：Biomaterials

authors： Linville RM,DeStefano JG,Sklar MB,Xu Z,Farrell AM,Bogorad MI,Chu C,Walczak P,Cheng L,Mahairaki V,Whartenby KA,Calabresi PA,Searson PC

更新日期：2019-01-01 00:00:00

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:Most part of pH- and temperature-sensitive microspheres used for the controlled delivery of drugs are not biodegradable. Therefore, the aim of this work is to prepare pH- and temperature-sensitive microspheres from biodegradable and biocompatible natural polymers. Pullulan microspheres were prepared by suspension cros...

journal_title：Biomaterials

authors： Fundueanu G,Constantin M,Ascenzi P

更新日期：2008-06-01 00:00:00

abstract：:We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe(2)O(4)) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs wate...

journal_title：Biomaterials

authors： Yang H,Zhang C,Shi X,Hu H,Du X,Fang Y,Ma Y,Wu H,Yang S

更新日期：2010-05-01 00:00:00

abstract：:We have synthesized and characterized a novel peptide fluorosurfactant polymer (PFSP) modification that facilitates the adhesion and growth of endothelial cells on expanded polytetrafluoroetheylene (ePTFE) vascular graft material. This PFSP consists of a poly(vinyl amine) (PVAm) backbone with integrin binding Arg-Gly-...

journal_title：Biomaterials

authors： Larsen CC,Kligman F,Kottke-Marchant K,Marchant RE

更新日期：2006-10-01 00:00:00

abstract：:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants...

journal_title：Biomaterials

authors： Yang Y,Qiao X,Huang R,Chen H,Shi X,Wang J,Tan W,Tan Z

更新日期：2020-02-01 00:00:00

abstract：:A Vroman-like exchange of different proteins adsorbing from a concentrated mixture to the same hydrophobic adsorbent surface is shown to arise naturally from the selective pressure imposed by a fixed interfacial-concentration capacity (w/v, mg/mL) for which protein molecules compete. A size (molecular weight, MW) disc...

journal_title：Biomaterials

authors： Noh H,Vogler EA

更新日期：2007-01-01 00:00:00

abstract：:The introduction of metal-on-metal total disc replacements motivated studies to evaluate the effects of cobalt-chromium (CoCr) nanoparticles on cells of the dura mater. Porcine fibroblasts and epithelial cells isolated from the dura mater were cultured with clinically-relevant CoCr nanoparticles and the ions, generate...

journal_title：Biomaterials

authors： Behl B,Papageorgiou I,Brown C,Hall R,Tipper JL,Fisher J,Ingham E

更新日期：2013-05-01 00:00:00

abstract：:High-density mesenchymal stem cell (MSC) aggregates can be guided to form bone-like tissue via endochondral ossification in vitro when culture media is supplemented with proteins, such as growth factors (GFs), to first guide the formation of a cartilage template, followed by culture with hypertrophic factors. Recent r...

journal_title：Biomaterials

authors： McMillan A,Nguyen MK,Gonzalez-Fernandez T,Ge P,Yu X,Murphy WL,Kelly DJ,Alsberg E

更新日期：2018-04-01 00:00:00

abstract：:Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for soft tissue augmentation and reconstruction. The objective of the current study was to investigate the effects of allogeneic adipose-derived stem/stromal cells (ASCs) on in vivo fat regeneration in DAT bioscaffolds using an immunoco...

journal_title：Biomaterials

authors： Han TT,Toutounji S,Amsden BG,Flynn LE

更新日期：2015-12-01 00:00:00

abstract：:The Raman laser and infrared spectra of doped bio-active glasses of the 45S5 type are presented and discussed. The spectroscopic results show that the doping agents cause the destruction of the basic glass structure and the consequent formation of SiO4(4-) units in the glass network. When the doped glasses have been i...

journal_title：Biomaterials

authors： Krajewski A,Ravaglioli A,Bertoluzza A,Monti P,Battaglia MA,Pizzoferrato A,Olmi R,Moroni A

更新日期：1988-11-01 00:00:00

abstract：:Chitosan-silica xerogel hybrid membranes were fabricated using a sol-gel process and their potential applications in guided bone regeneration (GBR) were investigated in terms of their in vitro cellular activity and in vivo bone regeneration ability. TEM observation revealed that the silica xerogel was dispersed in the...

journal_title：Biomaterials

authors： Lee EJ,Shin DS,Kim HE,Kim HW,Koh YH,Jang JH

更新日期：2009-02-01 00:00:00

abstract：:We analysed tissues harvested during 24 retrievals of hip joint prostheses, with one or both articular components made of alumina. We describe the morphology of wear particles, measure their size and analyse their chemical composition. We relate histopathological aspects to the parameters that characterize ceramic wea...

journal_title：Biomaterials

authors： Pizzoferrato A,Stea S,Sudanese A,Toni A,Nigrisoli M,Gualtieri G,Squarzoni S

更新日期：1993-07-01 00:00:00

abstract：:A new implant surface has been developed with the purpose of avoiding as much stress shielding as possible, and thus prolong the prosthesis lifespan. The aim of this study was to investigate the in vitro effect of this new ultra-high roughness and dense Titanium (Ti) surface (PG60, Ra = 74 microm) in comparison with m...

journal_title：Biomaterials

authors： Borsari V,Giavaresi G,Fini M,Torricelli P,Tschon M,Chiesa R,Chiusoli L,Salito A,Volpert A,Giardino R

更新日期：2005-08-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00

abstract：:The translation of experimental stroke research from the laboratory to successful clinical practice remains a formidable challenge. We previously reported that PEGylated-lipid nanoparticles (PLNs) effectively transport across the blood-brain barrier along with less inflammatory responses. In the present study, PLNs co...

journal_title：Biomaterials

authors： Lu YM,Huang JY,Wang H,Lou XF,Liao MH,Hong LJ,Tao RR,Ahmed MM,Shan CL,Wang XL,Fukunaga K,Du YZ,Han F

更新日期：2014-01-01 00:00:00

abstract：:Severe wear of the ultra-high molecular weight polyethylene (UHMWPE) components of total joint replacements limits their long-term success. In previous studies, the infrared spectra obtained on retrieved UHMWPE components were interpreted as evidence that the UHMWPE oxidizes in vivo. In direct contrast, infrared spect...

journal_title：Biomaterials

authors： James SP,Blazka S,Merrill EW,Jasty M,Lee KR,Bragdon CR,Harris WH

更新日期：1993-07-01 00:00:00

abstract：:The widespread use of synthetic transvaginal polypropylene mesh for treating Pelvic Organ Prolapse (POP) has been curtailed due to serious adverse effects highlighted in 2008 and 2011 FDA warnings and subsequent legal action. We are developing new synthetic mesh to deliver endometrial mesenchymal stem cells (eMSC) to ...

journal_title：Biomaterials

authors： Emmerson S,Mukherjee S,Melendez-Munoz J,Cousins F,Edwards SL,Karjalainen P,Ng M,Tan KS,Darzi S,Bhakoo K,Rosamilia A,Werkmeister JA,Gargett CE

更新日期：2019-12-01 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are compa...

journal_title：Biomaterials

authors： Koob TJ,Hernandez DJ

更新日期：2003-03-01 00:00:00

abstract：:In this study, the intra-articular tolerability and suitability for local and sustained release of an in situ forming gel composed of an acetyl-capped poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) copolymer loaded with celecoxib was investigated in horse join...

journal_title：Biomaterials

authors： Petit A,Redout EM,van de Lest CH,de Grauw JC,Müller B,Meyboom R,van Midwoud P,Vermonden T,Hennink WE,René van Weeren P

更新日期：2015-01-01 00:00:00

abstract：:Strangles is an infectious disease caused by Streptococcus equi subspecies equi that affects the upper respiratory tract of the Equidae. The control of this disease seems to be dependent on its earlier detection and prevention, but prolonged animal protection without development of strong and severe side effects has n...

journal_title：Biomaterials

authors： Florindo HF,Pandit S,Gonçalves LM,Videira M,Alpar O,Almeida AJ

更新日期：2009-10-01 00:00:00

abstract：:We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction cond...

journal_title：Biomaterials

authors： Glass JR,Dickerson KT,Stecker K,Polarek JW

更新日期：1996-06-01 00:00:00

abstract：:Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth factor is known to enhance chondrocyte differentiation and endochondral ossification during development, yet whether PGRN also plays a role in bone regeneration remains un...

journal_title：Biomaterials

authors： Zhao YP,Tian QY,Frenkel S,Liu CJ

更新日期：2013-09-01 00:00:00