Abstract:
:We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction conditions during peptide immobilization. Following cell attachment, cells actively proliferate and colonize the pores of the matrix. This material should prove useful for the maintenance of cells on a chemically defined three-dimensional substrate or as a scaffold for enhancing tissue repair.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Glass JR,Dickerson KT,Stecker K,Polarek JWdoi
10.1016/0142-9612(96)85911-4subject
Has Abstractpub_date
1996-06-01 00:00:00pages
1101-8issue
11eissn
0142-9612issn
1878-5905pii
0142961296859114journal_volume
17pub_type
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