Synthesis of a heparinized poly(organophosphazene).

abstract：:The neutrophil polarization assay, a technique used to measure chemotaxis, was adapted to examine complement activation. Complement activation in serum which had been incubated with metallic and polymeric biomaterials was examined using the neutrophil polarization assay and immunoelectrophoresis assay. In agreement wi...

journal_title：Biomaterials

authors： Remes A,Williams DF

更新日期：1991-08-01 00:00:00

abstract：:Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and m...

journal_title：Biomaterials

authors： Li X,Wang Y,Chen Y,Zhou P,Wei K,Wang H,Wang J,Fang H,Zhang S

更新日期：2020-10-01 00:00:00

abstract：:To fully understand biological behavior in vitro often dictates that oxygen be reported at either a local or a cellular level. Oxygen sensors based on the luminescent quenching of a specific form of electrospun fiber were developed for measurement of both gaseous and dissolved oxygen concentrations. Electrospinning wa...

journal_title：Biomaterials

authors： Xue R,Nelson MT,Teixeira SA,Viapiano MS,Lannutti JJ

更新日期：2016-01-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:Fluorescent Ⅱ-Ⅳ Quantum dots (QDs) have demonstrated to be highly promising biological probes for various biological and biomedical applications due to their many attractive merits, such as robust photostabilty, strong photoluminescence, and size-tunable fluorescence. Along with wide ranging bioapplications, concerns ...

journal_title：Biomaterials

authors： Su Y,Peng F,Jiang Z,Zhong Y,Lu Y,Jiang X,Huang Q,Fan C,Lee ST,He Y

更新日期：2011-09-01 00:00:00

abstract：:An urgent unmet need exists for early-stage treatment of spinal cord injury (SCI). Currently methylprednisolone is the only therapeutic agent used in clinics, for which the efficacy is controversial and the side effect is well-known. We demonstrated functional restoration of injured spinal cord by self-assembled nanop...

journal_title：Biomaterials

authors： Wu W,Lee SY,Wu X,Tyler JY,Wang H,Ouyang Z,Park K,Xu XM,Cheng JX

更新日期：2014-02-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disability and death worldwide. An effective therapeutic approach is urgently needed. Stroke-induced angiogenesis and neurogenesis are essential mechanisms in the long-term repair. Extracellular matrix proteins are also involved in tissue self-repair. Recently, a PHSRN (Pro-His-...

journal_title：Biomaterials

authors： Wu CC,Wang LC,Su YT,Wei WY,Tsai KJ

更新日期：2018-12-01 00:00:00

abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

journal_title：Biomaterials

authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

更新日期：2003-07-01 00:00:00

abstract：:The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...

journal_title：Biomaterials

authors： Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

更新日期：2011-08-01 00:00:00

abstract：:Remarkable water-stimulated shape memory effect was revealed in a natural biopolymer of peacock's tail covert feathers of which the innate shape can almost be fully recovered after severe deformation by a short hydration step. The shape memory effect manifests a good stability of high recovery rate and ratio during cy...

journal_title：Biomaterials

authors： Liu ZQ,Jiao D,Zhang ZF

更新日期：2015-10-01 00:00:00

abstract：:A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)...

journal_title：Biomaterials

authors： Holland J,Hersh L,Bryhan M,Onyiriuka E,Ziegler L

更新日期：1996-11-01 00:00:00

abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...

journal_title：Biomaterials

authors： Beamish JA,Geyer LC,Haq-Siddiqi NA,Kottke-Marchant K,Marchant RE

更新日期：2009-10-01 00:00:00

abstract：:Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, includin...

journal_title：Biomaterials

authors： Choi BH,Choi YS,Kang DG,Kim BJ,Song YH,Cha HJ

更新日期：2010-12-01 00:00:00

abstract：:Thermosensitive "micellar hydrogel" is prepared based on poly(ε-caprolactone-co- 1,4,8-trioxa[4.6]spiro-9-undecanone)-b-poly(ethylene glycol)- b-poly(ε-caprolactone- co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) triblock copolymer. Fluorescence resonance energy transfer (FRET) is adopted to explore its assembly (form...

journal_title：Biomaterials

authors： Huang P,Song H,Zhang Y,Liu J,Cheng Z,Liang XJ,Wang W,Kong D,Liu J

更新日期：2017-11-01 00:00:00

abstract：:To evaluate the biocompatibility of chemically and structurally modified polyurethane elastomers for use as blood vessel replacements, small squares of vascular prostheses were cultured in direct contact with endothelium from chick embryo aorta using an organotypic culture assay. The polyurethane materials tested were...

journal_title：Biomaterials

authors： Guidoin R,Sigot M,King M,Sigot-Luizard MF

更新日期：1992-01-01 00:00:00

abstract：:Excessive production of reactive oxygen species (ROS) is a hallmark feature in nanomaterials (NMs) induced cellular toxicity. However, the inter-relationship between NMs induced ROS generation and the cells innate ability to regulate intracellular ROS level in effecting a particular cellular outcome is currently under...

journal_title：Biomaterials

authors： Setyawati MI,Tay CY,Leong DT

更新日期：2013-12-01 00:00:00

abstract：:Carbon fiber implants were used to fill osteochondral defects created on the articular surface of the patella of 36 rabbits, for the purpose of studying the long-term histological changes of the repair process. Six months after surgery the defect was filled by fibrous tissue, where the superficial area was organized p...

journal_title：Biomaterials

authors： Carranza-Bencano A,Armas-Padrón JR,Gili-Miner M,Lozano MA

更新日期：2000-11-01 00:00:00

abstract：:Matrix anisotropy is important for long term in vivo functionality. However, it is not fully understood how to guide matrix anisotropy in vitro. Experiments suggest actin-mediated cell traction contributes. Although F-actin in 2D displays a stretch-avoidance response, 3D data are lacking. We questioned how cyclic stre...

journal_title：Biomaterials

authors： Foolen J,Deshpande VS,Kanters FM,Baaijens FP

更新日期：2012-10-01 00:00:00

abstract：:Nitric oxide (NO) is an important biological messenger involved in the treatment of bacterial infections, but its controlled and targeted release in bacterial infections remains a major challenge. Herein, an intelligent NO nanogenerator triggered by near-infrared (NIR) light is constructed for targeted treatment of P....

journal_title：Biomaterials

authors： Wu Y,Deng G,Jiang K,Wang H,Song Z,Han H

更新日期：2021-01-01 00:00:00

abstract：:High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such ...

journal_title：Biomaterials

authors： Moraes C,Wang G,Sun Y,Simmons CA

更新日期：2010-01-01 00:00:00

abstract：:In recent years, graphene and graphene-based nanocomposites owning to their highly enriched physical and chemical properties have been widely explored for applications in many different fields including biomedicine. In the present work, we decorate graphene oxide (GO) by both iron oxide nanoparticles (IONPs) and gold,...

journal_title：Biomaterials

authors： Shi X,Gong H,Li Y,Wang C,Cheng L,Liu Z

更新日期：2013-07-01 00:00:00

abstract：:Bioengineered tissue equivalents should provide physiologically relevant biochemical and mechanical cues to support the growth and differentiation of seeded cells. Herein, tubular dense collagen constructs (TDCCs) with collagen content comparable to native extracellular matrix were used to investigate the effect of sh...

journal_title：Biomaterials

authors： Ghezzi CE,Risse PA,Marelli B,Muja N,Barralet JE,Martin JG,Nazhat SN

更新日期：2013-03-01 00:00:00

abstract：:Pancreatic islet transplantation is one of the most promising strategies for patients suffering from type 1 diabetes mellitus, but several therapeutic immunosuppressive medications must be administered simultaneously to protect transplanted islets in the long-term, and these expose patients to the risk of serious comp...

journal_title：Biomaterials

authors： Yun Lee D,Hee Nam J,Byun Y

更新日期：2007-04-01 00:00:00

abstract：:This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-401). Crystallisation during biodegradation was not considered...

journal_title：Biomaterials

authors： Han X,Pan J

更新日期：2009-01-01 00:00:00

abstract：:Graphene oxide (GO) immunotoxicity is not clarified well up to date. Herein we reported the effects of GOs with and without polyvinylpyrrolidone (PVP) coating on human immune cells such as dendritic cells (DCs), T lymphocytes and macrophages. Human immune cells such as dendritic cells (DCs), T lymphocytes and macropha...

journal_title：Biomaterials

authors： Zhi X,Fang H,Bao C,Shen G,Zhang J,Wang K,Guo S,Wan T,Cui D

更新日期：2013-07-01 00:00:00

abstract：:A major role of respiratory mucus is to trap inhaled particles, including pathogens and environmental particulates, to limit body exposure. Despite the tremendous health implications, how particle size and surface chemistry affect mobility in respiratory mucus from humans without lung disease is not known. We prepared...

journal_title：Biomaterials

authors： Schuster BS,Suk JS,Woodworth GF,Hanes J

更新日期：2013-04-01 00:00:00

abstract：:The flexural strength of five glass ionomers was measured at intervals ranging from 1 h to 3 months after mixing. The pattern of change in flexural strength is material-specific with two water-activated materials having significantly higher long-term flexural strengths than the others. This may be attributable to the ...

journal_title：Biomaterials

authors： Pearson GJ,Atkinson AS

更新日期：1991-09-01 00:00:00

abstract：:Mesoporous silica (MPS), synthesized via the supramolecular polymer templating method, is one of the most attractive nanomaterials for biomedical applications, such as drug delivery systems, labeling, and tissue engineering. The significant difference between MPS and general silica (colloidal silica) is the pore archi...

journal_title：Biomaterials

authors： Lee S,Yun HS,Kim SH

更新日期：2011-12-01 00:00:00

abstract：:Despite clinical exploitation of exendin 4 for the treatment of type 2 diabetes, the significantly short half-life requiring twice a day injection has limited the wide applications. In this work, a protocol for the synthesis of long acting hyaluronate (HA) - exendin 4 conjugate was successfully developed using Michael...

journal_title：Biomaterials

authors： Kong JH,Oh EJ,Chae SY,Lee KC,Hahn SK

更新日期：2010-05-01 00:00:00

abstract：:Inorganic phosphate (Pi) is a physiological regulator of osteoblasts and chondrocytes, suggesting that phosphate may contribute to the biological response of these cells to bioactive glasses like Bioglass 45S5, which is composed of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5. We investigated the effect of varying the...

journal_title：Biomaterials

authors： Lossdörfer S,Schwartz Z,Lohmann CH,Greenspan DC,Ranly DM,Boyan BD

更新日期：2004-06-01 00:00:00