Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors.

abstract：:Composite particles made by growing nanoscopic silicon wires from the surface of monodispersed, microsized silica beads were tested in this study for their ability to affect the integrity and permeability of an epithelial cell layer. Polyethylene glycol (PEG) is known to sterically stabilize particles and prevent prot...

journal_title：Biomaterials

authors： Uskoković V,Lee PP,Walsh LA,Fischer KE,Desai TA

更新日期：2012-02-01 00:00:00

abstract：:The urgent needs of functional arterial replacements for curing the vascular system diseases have been proposed for many years. However, an ideal small-diameter vascular scaffold, which is nonthrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of natural vessels, and supports neovascular tis...

journal_title：Biomaterials

authors： Han F,Jia X,Dai D,Yang X,Zhao J,Zhao Y,Fan Y,Yuan X

更新日期：2013-10-01 00:00:00

abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

journal_title：Biomaterials

authors： Davies EH,Kuhn AT

更新日期：1984-11-01 00:00:00

abstract：:An independent assessment was performed of the results of woven carbon implants of mesh or rods into articular cartilage defects performed by two surgeons in the knees of 96 patients. Eight had symptomatic osteochondritis, 31 had chondromalacia patellae and 57 had early osteoarthritis. They were reviewed up to 5 yr af...

journal_title：Biomaterials

authors： Pongor P,Betts J,Muckle DS,Bentley G

更新日期：1992-01-01 00:00:00

abstract：:Colloidal nanoparticle drug delivery systems have attracted much interest for their ability to enable effective formulation and delivery of therapeutic agents. The selective delivery of these nanoparticles to the disease site can be enhanced by coating the surface of the nanoparticles with targeting moieties, such as ...

journal_title：Biomaterials

authors： Fay F,McLaughlin KM,Small DM,Fennell DA,Johnston PG,Longley DB,Scott CJ

更新日期：2011-11-01 00:00:00

abstract：:Chlorin-core star-shaped block copolymer (CSBC) may self-assemble to form micelles, which act as nanosized photosensitizing agents for photodynamic therapy (PDT) and further encapsulate hydrophobic drugs. This functionalized micellar delivery system is a potential dual carrier for the synergistic combination of photod...

journal_title：Biomaterials

authors： Peng CL,Lai PS,Lin FH,Yueh-Hsiu Wu S,Shieh MJ

更新日期：2009-07-01 00:00:00

abstract：:We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction cond...

journal_title：Biomaterials

authors： Glass JR,Dickerson KT,Stecker K,Polarek JW

更新日期：1996-06-01 00:00:00

abstract：:Sol-gel derived porous silica carriers for the controlled release of proteins were synthesized using a room temperature process. The materials are intended to serve as both substrates for bone growth as well as to allow incorporated proteins such as growth factors to diffuse out and stimulate cell function and tissue ...

journal_title：Biomaterials

authors： Santos EM,Radin S,Ducheyne P

更新日期：1999-09-01 00:00:00

abstract：:The ability to precisely pattern embryonic stem (ES) cells in vitro into predefined arrays/geometries may allow for the recreation of a stem cell niche for better understanding of how cellular microenvironmental factors govern stem cell maintenance and differentiation. In this study, a new gelatin-based laser direct-w...

journal_title：Biomaterials

authors： Raof NA,Schiele NR,Xie Y,Chrisey DB,Corr DT

更新日期：2011-03-01 00:00:00

abstract：:As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

journal_title：Biomaterials

authors： England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

更新日期：2016-09-01 00:00:00

abstract：:This study was undertaken to evaluate the role of collagen matrix to enhance platelet-rich plasma (PRP) effects on pro-inflammatory cytokine-induced arthritic model. We have previously demonstrated the highly regenerative roles of PRP to restore disc degeneration and osteoporosis. In this study, PRP modulated by colla...

journal_title：Biomaterials

authors： Wu CC,Chen WH,Zao B,Lai PL,Lin TC,Lo HY,Shieh YH,Wu CH,Deng WP

更新日期：2011-09-01 00:00:00

abstract：:Stem cell therapy is a promising therapeutic method for the treatment of ischemic heart diseases; however, some challenges prohibit the efficacy after cell delivery due to hostile microenvironment of the injured myocardium. 3D printed pre-vascularized stem cell patch can enhance the therapeutic efficacy for cardiac re...

journal_title：Biomaterials

authors： Jang J,Park HJ,Kim SW,Kim H,Park JY,Na SJ,Kim HJ,Park MN,Choi SH,Park SH,Kim SW,Kwon SM,Kim PJ,Cho DW

更新日期：2017-01-01 00:00:00

abstract：:Electrically conducting polymers hold promise for developing advanced neuroprostheses, bionic systems and neural repair devices. Among them, poly(3, 4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) exhibits superior physicochemical properties but biocompatibility issues have limited its use. We d...

journal_title：Biomaterials

authors： Collazos-Castro JE,Polo JL,Hernández-Labrado GR,Padial-Cañete V,García-Rama C

更新日期：2010-12-01 00:00:00

abstract：:Over the past two decades, in vitro autologous endothelial cell (EC) coverage of expanded polytetrafluoroethylene (ePTFE) graft has been developed and clinically applied with success in infrainguinal bypasses. Before endothelialization, the luminal surface of the graft has to be coated with a currently used fibrinolyt...

journal_title：Biomaterials

authors： Fernandez P,Deguette A,Pothuaud L,Belleannée G,Coste P,Bordenave L

更新日期：2005-08-01 00:00:00

abstract：:We investigated the in vitro effects of the molecular weight (MW) of hyaluronic acid (HA) on the maintenance of the pluripotency and proliferation of murine embryonic stem (ES) cells. High (1000 kDa) or low (4-8 kDa) MW HA was derivatized using an ultraviolet-reactive compound, 4-azidoaniline, and the derivative was i...

journal_title：Biomaterials

authors： Joddar B,Kitajima T,Ito Y

更新日期：2011-11-01 00:00:00

abstract：:Ectopic expression of heme oxygenase-1 (HO-1) in ischemic tissue protects the tissue from apoptosis and necrosis and promotes angiogenesis. However, apoptosis and necrosis will decrease HO-1 gene transfection efficacy. We hypothesized that fibroblast growth factor-2 (FGF2) would attenuate ischemic damage during the in...

journal_title：Biomaterials

authors： Bhang SH,Kim JH,Yang HS,La WG,Lee TJ,Sun AY,Kim GH,Lee M,Kim BS

更新日期：2009-10-01 00:00:00

abstract：:Peripheral nerve injuries often lead to incomplete recovery and contribute to significant disability to approximately 360,000 people in the USA each year. Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and differentiation potential in vivo are stil...

journal_title：Biomaterials

authors： Du J,Zhen G,Chen H,Zhang S,Qing L,Yang X,Lee G,Mao HQ,Jia X

更新日期：2018-10-01 00:00:00

abstract：:It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for some complications. Aimed to have a better understanding of the specific role of T-80 coating on nanoparticles and simplify the problem,...

journal_title：Biomaterials

authors： Sun W,Xie C,Wang H,Hu Y

更新日期：2004-07-01 00:00:00

abstract：:Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread cells. Additionally, the system facilitates immuno-fluorescent staining of aspirated cells to investi...

journal_title：Biomaterials

authors： Reynolds NH,Ronan W,Dowling EP,Owens P,McMeeking RM,McGarry JP

更新日期：2014-04-01 00:00:00

abstract：:Alginate-polylysine (PLL) capsules are commonly applied for immunoprotection of endocrine tissues. Alginate is composed of mannuronic acid (M) and guluronic acid (G). Different types of alginate have different ratios of G to M, but little is known of the influence of these differences on biocompatibility. Therefore, w...

journal_title：Biomaterials

authors： De Vos P,De Haan B,Van Schilfgaarde R

更新日期：1997-02-01 00:00:00

abstract：:An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge of achieving desirab...

journal_title：Biomaterials

authors： Volpatti LR,Facklam AL,Cortinas AB,Lu YC,Matranga MA,MacIsaac C,Hill MC,Langer R,Anderson DG

更新日期：2021-01-01 00:00:00

abstract：:Targeted therapy is needed for hepatitis B virus (HBV)-mediated hepatocellular carcinoma (HCC) which shows overexpression of HBV surface antigen (HBsAg). We previously developed scFv15, a human single-chain antibody against HBsAg. Here we tested the strategic feasibility of scFv15-mediated delivery of apoptotic effect...

journal_title：Biomaterials

authors： Yan B,Ouyang Q,Zhao Z,Cao F,Wang T,Jia X,Meng Y,Jiang S,Liu J,Chen R,Jia L,Zhang R,Wen W,Jin B,Chen S,Zhao J,Yang A

更新日期：2013-07-01 00:00:00

abstract：:The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode. The friction force and adhesive force measurements were able to differentiate the non-crosslinked pHEMA chains from the surface of the crosslinked pHEMA n...

journal_title：Biomaterials

authors： Kim SH,Marmo C,Somorjai GA

更新日期：2001-12-01 00:00:00

abstract：:An increasing number of treatments of metastases rely on diagnostics and imaging these days. The facts that the activity of cathepsin B (CB) is markedly linked to the metastatic process and that CB is found highly expressed in the pericellular regions in this process make CB an attractive target for diagnosing metasta...

journal_title：Biomaterials

authors： Ryu JH,Na JH,Ko HK,You DG,Park S,Jun E,Yeom HJ,Seo DH,Park JH,Jeong SY,Kim IS,Kim BS,Kwon IC,Choi K,Kim K

更新日期：2014-02-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:Macropores in tissue engineering scaffolds provide space for vascularization, cell-proliferation and cellular interactions, and is crucial for successful tissue regeneration. Modulating the size and density of macropores may promote desirable cellular processes at different stages of tissue development. Most current t...

journal_title：Biomaterials

authors： Han LH,Lai JH,Yu S,Yang F

更新日期：2013-06-01 00:00:00

abstract：:Ultra-high molecular-weight polyethylene (UHMWPE) has been used in total joint replacement for the last three decades. Despite the recent advancements in prosthesis design, the wear of UHMWPE remains a serious clinical problem; the release of wear debris may induce osteolysis and implant loosening. Controlling the qua...

journal_title：Biomaterials

authors： Affatato S,Bersaglia G,Emiliani D,Foltran I,Taddei P,Reggiani M,Ferrieri P,Toni A

更新日期：2003-10-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:We design a class of imprinted hybrid microgels that can optically monitor glucose levels with high sensitivity and selectivity in complex media at physiological pH, acting like a "glucose-indicator". Such imprinted hybrid microgels were made of Ag nanoparticles (NPs) in situ immobilized in molecularly imprinted gluco...

journal_title：Biomaterials

authors： Wu W,Shen J,Li Y,Zhu H,Banerjee P,Zhou S

更新日期：2012-10-01 00:00:00

abstract：:Angiogenesis is critical in the early stage of reparative processes and tissue regeneration, but the persistence of a vascular network may interfere with later transformation/maturation in naturally avascular tissues such as articular cartilage. Our supposition is that the timed delivery of an anti-angiogenic factor i...

journal_title：Biomaterials

authors： Sun XD,Jeng L,Bolliet C,Olsen BR,Spector M

更新日期：2009-02-01 00:00:00