Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors.

abstract：:Osteoinductive biomaterials are promising for bone repair. There is no direct proof that bone marrow mesenchymal stem cells (BMSCs) home to non-osseous sites and participate in ectopic bone formation induced by osteoinductive bioceramics. The objective of this study was to use a sex-mismatched beagle dog model to inve...

journal_title：Biomaterials

authors： Song G,Habibovic P,Bao C,Hu J,van Blitterswijk CA,Yuan H,Chen W,Xu HH

更新日期：2013-03-01 00:00:00

abstract：:Layered double hydroxide (LDH) nanoparticles are attractive as potential drug vectors for the targeting not only of tissues, but also of intracellular organelles, and particularly the acidic endolysosomes created after cell endocytosis. The purpose of this study was to investigate the ability of LDH nanoparticles desi...

journal_title：Biomaterials

authors： Li A,Qin L,Zhu D,Zhu R,Sun J,Wang S

更新日期：2010-02-01 00:00:00

abstract：:The development of a method that can efficiently deliver nucleic acids into the nucleus of living systems remains one of the key challenges for experimental and therapeutic use of nonbiological gene delivery agents. In the current study, we demonstrate a functionalized gold nanoparticle (AuNP) that can serve as a univ...

journal_title：Biomaterials

authors： Kim DW,Kim JH,Park M,Yeom JH,Go H,Kim S,Han MS,Lee K,Bae J

更新日期：2011-04-01 00:00:00

abstract：:Despite serving as the clinical "gold standard" treatment for critical size bone defects, decellularized allografts suffer from long-term failure rates of ~60% due to the absence of the periosteum. Stem and osteoprogenitor cells within the periosteum orchestrate autograft healing through host cell recruitment, which i...

journal_title：Biomaterials

authors： Li Y,Hoffman MD,Benoit DSW

更新日期：2021-01-01 00:00:00

abstract：:Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this pur...

journal_title：Biomaterials

authors： Nuhn L,Van Hoecke L,Deswarte K,Schepens B,Li Y,Lambrecht BN,De Koker S,David SA,Saelens X,De Geest BG

更新日期：2018-09-01 00:00:00

abstract：:A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)...

journal_title：Biomaterials

authors： Holland J,Hersh L,Bryhan M,Onyiriuka E,Ziegler L

更新日期：1996-11-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:Although PEGylated liposome-based drug delivery systems hold great promising applications for cancer therapy due to their prolonged blood circulation time, PEGylation significantly reduces their cellular uptake, which markedly impairs the in vivo tumor retention and antitumor efficiency of drug-loaded liposomes. Most ...

journal_title：Biomaterials

authors： Li Y,Liu R,Yang J,Shi Y,Ma G,Zhang Z,Zhang X

更新日期：2015-02-01 00:00:00

abstract：:Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of...

journal_title：Biomaterials

authors： Ke W,Yin W,Zha Z,Mukerabigwi JF,Chen W,Wang Y,He C,Ge Z

更新日期：2018-02-01 00:00:00

abstract：:The development of biocompatible photopolymerizing polymers for biomedical and tissue engineering applications has the potential to reduce the invasiveness and cost of biomaterial implants designed to repair or augment tissues. However, more information is needed about the cellular toxicity of the compounds and initia...

journal_title：Biomaterials

authors： Williams CG,Malik AN,Kim TK,Manson PN,Elisseeff JH

更新日期：2005-04-01 00:00:00

abstract：:Collagen, type I, is a highly abundant natural protein material which has been cross-linked by a variety of methods including chemical agents, physical heating and UV irradiation with the aim of enhancing its physical characteristics such as mechanical strength, thermal stability, resistance to proteolytic breakdown, ...

journal_title：Biomaterials

authors： Chau DY,Collighan RJ,Verderio EA,Addy VL,Griffin M

更新日期：2005-11-01 00:00:00

abstract：:Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently ena...

journal_title：Biomaterials

authors： Viswanathan P,Ondeck MG,Chirasatitsin S,Ngamkham K,Reilly GC,Engler AJ,Battaglia G

更新日期：2015-06-01 00:00:00

abstract：:Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...

journal_title：Biomaterials

authors： Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

更新日期：2012-12-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are the vital, life-long source of all blood cell types. They are found in stem cell niches, specific anatomic locations that offer all the factors and signals necessary for the maintenance of the stem cell potential of HSCs. Much attention has been paid to the biochemical composition o...

journal_title：Biomaterials

authors： Altrock E,Muth CA,Klein G,Spatz JP,Lee-Thedieck C

更新日期：2012-04-01 00:00:00

abstract：:Water uptake characteristics of BisGMA-based composites incorporating untreated and surface-treated hydroxyapatite (HA) with a silane coupling agent have been investigated. The water absorption and desorption behaviour of these composites obeyed the classical diffusion theory. The diffusion coefficients of the composi...

journal_title：Biomaterials

authors： Santos C,Clarke RL,Braden M,Guitian F,Davy KW

更新日期：2002-04-01 00:00:00

abstract：:MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics prob...

journal_title：Biomaterials

authors： Kim JK,Choi KJ,Lee M,Jo MH,Kim S

更新日期：2012-01-01 00:00:00

abstract：:The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...

journal_title：Biomaterials

authors： Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

更新日期：2011-09-01 00:00:00

abstract：:A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...

journal_title：Biomaterials

authors： Zeng S,Xiong MP

更新日期：2013-09-01 00:00:00

abstract：:As synergistic photothermal immunotherapy has developed as one of the most attractive strategies for cancer therapy, it is crucial to design an effective photothermal immunotherapy system to enhance the synergistic anti-tumor effect and reveal the essential role of each treatment. In this study, we designed CpG self-c...

journal_title：Biomaterials

authors： Dong X,Liang J,Yang A,Qian Z,Kong D,Lv F

更新日期：2019-07-01 00:00:00

abstract：:Efficient and site-specific delivery of anticancer drugs to tumors is important in the development of effective cancer chemotherapy. As an undecapeptide of the tachykinin neuropeptide family, the substance P (SP)/neurokinin-1 receptor (NK1R) system has been identified as a promising ligand-receptor pair in tumor-speci...

journal_title：Biomaterials

authors： Wu J,Zhou Y,Li S,Qu D,Zhu WH,Tian H

更新日期：2017-03-01 00:00:00

abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

journal_title：Biomaterials

authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

更新日期：2011-12-01 00:00:00

abstract：:Control of the precise location and extent of cellular attachment and proliferation, and of tissue outgrowth is important in a number of biomedical applications, including biomaterials and tissue engineered medical devices. Here we describe a method to control and direct the location and define boundaries of tissue gr...

journal_title：Biomaterials

authors： Thissen H,Johnson G,Hartley PG,Kingshott P,Griesser HJ

更新日期：2006-01-01 00:00:00

abstract：:A homogeneous glycidyl acrylate polymer (GAP) has been grafted on to polytetrafluoroethylene (PTFE) and polyethylene (PE) using a modified plasma glow discharge technique with glycidyl acrylate. The polymeric layer appears to be extremely stable to acidic media and to common organic solvents. The modified surface can ...

journal_title：Biomaterials

authors： Tanfani F,Durrani AA,Kojima M,Chapman D

更新日期：1990-10-01 00:00:00

abstract：:Fibrosis affects most organs, it results in replacement of normal parenchymal tissue with collagen-rich extracellular matrix, which compromises tissue architecture and ultimately causes loss of function of the affected organ. Biochemical pathways that contribute to fibrosis have been extensively studied, but the role ...

journal_title：Biomaterials

authors： Varkey M,Ding J,Tredget EE,Wound Healing Research Group.

更新日期：2014-12-01 00:00:00

abstract：:Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of interaction remains ...

journal_title：Biomaterials

authors： Onal S,Turker-Burhan M,Bati-Ayaz G,Yanik H,Pesen-Okvur D

更新日期：2021-01-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disability and death worldwide. An effective therapeutic approach is urgently needed. Stroke-induced angiogenesis and neurogenesis are essential mechanisms in the long-term repair. Extracellular matrix proteins are also involved in tissue self-repair. Recently, a PHSRN (Pro-His-...

journal_title：Biomaterials

authors： Wu CC,Wang LC,Su YT,Wei WY,Tsai KJ

更新日期：2018-12-01 00:00:00

abstract：:The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in three-dimensions (3D). A facile method was developed to modify gelatin with cysteine via a bifunctional PEG linker, thus intr...

journal_title：Biomaterials

authors： Fu Y,Xu K,Zheng X,Giacomin AJ,Mix AW,Kao WJ

更新日期：2012-01-01 00:00:00

abstract：:Integrating inductivity with conductivity in a material may advance tissue engineering. An organic/inorganic hybrid was developed by incorporating plasmid DNA encoding for the beta-gal gene complexed with Lipofectamine 2000 (DNA-Lipoplex) within apatite via coprecipitation. It was hypothesized that this system will re...

journal_title：Biomaterials

authors： Luong LN,McFalls KM,Kohn DH

更新日期：2009-12-01 00:00:00

abstract：:Although synergistic therapy for tumors has displayed significant promise for effective treatment of cancer, developing a simple and effective strategy to build a multi-functional nanoplatform is still a huge challenge. By virtue of the characteristics of tumor microenvironment, such as hypoxia, slight acidity and H2O...

journal_title：Biomaterials

authors： Wang M,Chang M,Chen Q,Wang D,Li C,Hou Z,Lin J,Jin D,Xing B

更新日期：2020-09-01 00:00:00

abstract：:Pancreatic cancer has the worst prognosis of all cancers due to disease aggressiveness and paucity of early detection platforms. We developed biomaterial scaffolds that recruit metastatic tumor cells and reflect the immune dysregulation of native metastatic sites. While this platform has shown promise in orthotopic br...

journal_title：Biomaterials

authors： Bushnell GG,Orbach SM,Ma JA,Crawford HC,Wicha MS,Jeruss JS,Shea LD

更新日期：2020-12-23 00:00:00