Bioelectrochemical control of neural cell development on conducting polymers.

abstract：:There is a need for new therapeutic strategies to treat bone defects caused by trauma, disease or tissue loss. Injectable systems for cell transplantation have the advantage of allowing the use of minimally invasive surgical procedures, and thus for less discomfort to patients. In the present study, it is hypothesized...

journal_title：Biomaterials

authors： Evangelista MB,Hsiong SX,Fernandes R,Sampaio P,Kong HJ,Barrias CC,Salema R,Barbosa MA,Mooney DJ,Granja PL

更新日期：2007-09-01 00:00:00

abstract：:Polyetheretherketone-hydroxyapatite composites were developed as alternative materials for load-bearing orthopedic applications. The amount of hydroxyapatite (HA) incorporated into the polyetheretherketone (PEEK) polymer matrix ranges from 5 to 40 vol% and these materials were successfully fabricated by injection mold...

journal_title：Biomaterials

authors： Abu Bakar MS,Cheng MH,Tang SM,Yu SC,Liao K,Tan CT,Khor KA,Cheang P

更新日期：2003-06-01 00:00:00

abstract：:In order to evaluate degradation kinetics and biocompatibility of a resorbable poly(D,L-lactic acid) (PDLLA) plug for total cemented hip prostheses, an experimental in vitro and in vivo study was carried out. Degradation rate studies were performed in Ringer solution and after in vivo plug implantation in the femoral ...

journal_title：Biomaterials

authors： Giardino R,Fini M,Aldini NN,Giavaresi G,Rocca M,Orienti L,de Lollis A,Fambri L

更新日期：1997-07-01 00:00:00

abstract：:Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated HSCs, which are the main contributors to liver fibrosis. Hence, a strategy for regulating HSC activation is important in the trea...

journal_title：Biomaterials

authors： Wang S,Kim J,Lee C,Oh D,Han J,Kim TJ,Kim SW,Seo YS,Oh SH,Jung Y

更新日期：2019-10-01 00:00:00

abstract：:The production profile of interleukin 1 (IL-1) from mouse peritoneal macrophages (M phi) was determined following their incubation with poly(DL-lactic acid) (PDLLA) granules containing ovalbumin (OVA). Upon incubation, M phi produced IL-1 at a significantly high rate compared with those incubated with OVA in the free ...

journal_title：Biomaterials

authors： Nakaoka R,Tabata Y,Ikada Y

更新日期：1996-12-01 00:00:00

abstract：:Understanding how nanovectors transport DNA molecules through cell membranes is of great importance in gene therapy. In this paper, we systematically investigate the mechanism of cellular uptake of cationic polymeric nanovectors containing DNA molecules through dissipative particle dynamics simulations. Our results sh...

journal_title：Biomaterials

authors： Ding HM,Ma YQ

更新日期：2013-11-01 00:00:00

abstract：:Bioglass 45S5 is a silica-based melt-derived glass, used in medical field as a bone regenerative material because of the deposition of a layer of hydroxy carbonate apatite (HCA) on the surface of the glass when immersed in body fluid. The present paper studies the early steps of reaction of 2-microm sized particles of...

journal_title：Biomaterials

authors： Cerruti M,Greenspan D,Powers K

更新日期：2005-05-01 00:00:00

abstract：:Simultaneous detection of multiple antigens by conventional immunological methods has been limited by the source of primary antibodies. Each antibody should be derived from a different host species (or subclass of immunoglobulin (Ig)) for suppressing the cross-reactions of secondary antibodies. Here we describe an inn...

journal_title：Biomaterials

authors： Iijima M,Matsuzaki T,Yoshimoto N,Niimi T,Tanizawa K,Kuroda S

更新日期：2011-12-01 00:00:00

abstract：:This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...

journal_title：Biomaterials

authors： Orlandi L,Solmi R,Krajewski A,Bearzatto A,Biagini G,Ciccopiedi E,Ravaglioli A

更新日期：1997-07-01 00:00:00

abstract：:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light ...

journal_title：Biomaterials

authors： da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

更新日期：2002-07-01 00:00:00

abstract：:The purpose of this article is to examine the effects of tricaprin on the physical characteristics and in vitro release of etoposide from poly (lactic-co-glycolic acid) microspheres. The microspheres were synthesized through the use of a single-emulsion solvent-extraction procedure. Samples from each batch of microsph...

journal_title：Biomaterials

authors： Schaefer MJ,Singh J

更新日期：2002-08-01 00:00:00

abstract：:Microencapsulation of dopamine-secreting cells in biocompatible, semi-permeable polymer membranes has been proposed as an alternative strategy for dopamine replacement for Parkinson's disease. In order to assess the viability of this proposal, dopamine-secreting PC12 cells were immunoisolated via microencapsulation in...

journal_title：Biomaterials

authors： Campioni EG,Nobrega JN,Sefton MV

更新日期：1998-04-01 00:00:00

abstract：:PVA-AA, an esterification product of poly(vinyl alcohol) and acryloyl chloride, was synthesized and tested for its dentine bonding ability as an additive to 2-hydroxyethyl methacrylate (HEMA). The dentine bonding strength increased significantly by increasing the concentration of PVA-AA in HEMA. The dentine tensile bo...

journal_title：Biomaterials

authors： Gung YW,Kuo SM,Wang YJ

更新日期：1997-02-01 00:00:00

abstract：:Tissue-engineered muscle is a viable option for tissue repair, though presently technologies are not developed enough to produce tissue in vitro identical to that in vivo. One important step in generating accurate engineered muscle is to mimic natural muscle architecture. Skeletal muscle is composed of fibrils whose o...

journal_title：Biomaterials

authors： Lam MT,Sim S,Zhu X,Takayama S

更新日期：2006-08-01 00:00:00

abstract：:Cationic solid lipid nanoparticles (cSLNs) are promising nanoparticles for controlled drug delivery. Increasing surface charge and/or reducing PEG density enhance cellular uptake of cSLNs in vitro, but for unknown reasons fail to improve drug delivery in vivo. Herein, we show that cSLNs present a risk for systemic pla...

journal_title：Biomaterials

authors： Wu X,Chen H,Wu C,Wang J,Zhang S,Gao J,Wang H,Sun T,Yang YG

更新日期：2018-02-01 00:00:00

abstract：:A comparative study of in vitro bioactivity of a sol-gel glass with composition 55% SiO2-41%CaO-4%P2O5 has been carried out by soaking it in a simulated body fluid (SBF) with and without exchange of this solution. When SBF is kept constant (static assay) the solution composition changes, increasing the Ca2+ concentrat...

journal_title：Biomaterials

authors： Rámila A,Vallet-Regí M

更新日期：2001-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect vertebrates by killing infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB-induced apoptosis of target cells causes inflammatory disease and chronic transplant rejection and so is an important disease target. The aim...

journal_title：Biomaterials

authors： Cheng W,Yang C,Hedrick JL,Williams DF,Yang YY,Ashton-Rickardt PG

更新日期：2013-05-01 00:00:00

abstract：:The present study deals with the synthesis and characterization of radiopaque polymers which could, when solubilized in an appropriate water-miscible solvent, be useful embolic materials for the treatment of cerebral aneurysms and arteriovenous malformations. For this purpose cellulose (both microcrystalline and powde...

journal_title：Biomaterials

authors： Mottu F,Rüfenacht DA,Laurent A,Doelker E

更新日期：2002-01-01 00:00:00

abstract：:Periprosthetic tissues observed at sites of loose total joint implants exhibit abundant macrophages, lymphocytes, fibroblasts and particulate debris. Macrophages phagocytose orthopaedic debris and release proinflammatory cytokines, chemokines, matrix metalloproteinases and other substances. In addition, other cell typ...

journal_title：Biomaterials

authors： Trindade MC,Lind M,Sun D,Schurman DJ,Goodman SB,Smith RL

更新日期：2001-02-01 00:00:00

abstract：:The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystall...

journal_title：Biomaterials

authors： Han CM,Lee EJ,Kim HE,Koh YH,Kim KN,Ha Y,Kuh SU

更新日期：2010-05-01 00:00:00

abstract：:The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were synthesised via RAFT polymerisation to feature glutamate urea targeting ligands for PSMA on the periphery. The chemotherapeutic, doxorubicin, was...

journal_title：Biomaterials

authors： Pearce AK,Simpson JD,Fletcher NL,Houston ZH,Fuchs AV,Russell PJ,Whittaker AK,Thurecht KJ

更新日期：2017-10-01 00:00:00

abstract：:Antigen-specific treatments are highly desirable for autoimmune diseases in contrast to treatments which induce systemic immunosuppression. A novel antigen-specific therapy has been developed which, when administered semi-therapeutically, is highly efficacious in the treatment of the mouse model for multiple sclerosis...

journal_title：Biomaterials

authors： Cho JJ,Stewart JM,Drashansky TT,Brusko MA,Zuniga AN,Lorentsen KJ,Keselowsky BG,Avram D

更新日期：2017-10-01 00:00:00

abstract：:One of the main issues in orthopaedic implant design is the fabrication of scaffolds that closely mimic the biomechanical properties of the surrounding bone. This research reports on a multi-stage rapid prototyping technique that was successfully developed to produce porous titanium scaffolds with fully interconnected...

journal_title：Biomaterials

authors： Ryan GE,Pandit AS,Apatsidis DP

更新日期：2008-09-01 00:00:00

abstract：:Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal signaling. A common strategy for replacing lost neurons is the injection of dissociated neural stem cells or differentiated neurons. However, this method is unl...

journal_title：Biomaterials

authors： Liaudanskaya V,Jgamadze D,Berk AN,Bischoff DJ,Gu BJ,Hawks-Mayer H,Whalen MJ,Chen HI,Kaplan DL

更新日期：2019-02-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:Peripherally inserted central catheters (PICCs) are hollow polymeric tubes that transport nutrients, blood and medications to neonates. To determine proper PICC placement, frequent X-ray imaging of neonates is performed. Because X-rays pose severe health risks to neonates, safer alternatives are needed. We hypothesize...

journal_title：Biomaterials

authors： Stevenson AT Jr,Reese LM,Hill TK,McGuire J,Mohs AM,Shekhar R,Bickford LR,Whittington AR

更新日期：2015-06-01 00:00:00

abstract：:Infection constitutes a major risk for implant failure, but the reasons why biomaterial sites are more vulnerable than normal tissue are not fully elucidated. In this study, a soft tissue infection model was developed, allowing the analysis of cellular and molecular responses in each of the sub-compartments of the imp...

journal_title：Biomaterials

authors： Svensson S,Trobos M,Hoffman M,Norlindh B,Petronis S,Lausmaa J,Suska F,Thomsen P

更新日期：2015-02-01 00:00:00

abstract：:Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...

journal_title：Biomaterials

authors： Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

更新日期：2012-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibr...

journal_title：Biomaterials

authors： Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

更新日期：2016-11-01 00:00:00

abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

journal_title：Biomaterials

authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

更新日期：2012-10-01 00:00:00