Abstract:
:Graphene oxide (GO) immunotoxicity is not clarified well up to date. Herein we reported the effects of GOs with and without polyvinylpyrrolidone (PVP) coating on human immune cells such as dendritic cells (DCs), T lymphocytes and macrophages. Human immune cells such as dendritic cells (DCs), T lymphocytes and macrophages were isolated from health donated bloods, PVP-coating GO (PVP-GO) exhibited lower immunogenicity compared with pure GO on the aspect of inducing differentiation and maturation of dendritic cells (DCs), the levels of secreted TNF-α and IL-1β had no obvious difference between two groups, yet the secretion of IL-6 remained in PVP-coating GO group. In addition, PVP-coating GO delayed significantly the apoptotic process of T lymphocytes, at the same time, and exhibited anti-phagocytosis ability against macrophages and markedly enhanced the physiological activity of macrophages. In conclusion, PVP-coating GO possesses good immunological biocompatibility and immunoenhancement effects in vitro, and is likely to be an available candidate of immunoadjuvant in the future.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Zhi X,Fang H,Bao C,Shen G,Zhang J,Wang K,Guo S,Wan T,Cui Ddoi
10.1016/j.biomaterials.2013.03.024subject
Has Abstractpub_date
2013-07-01 00:00:00pages
5254-61issue
21eissn
0142-9612issn
1878-5905pii
S0142-9612(13)00321-9journal_volume
34pub_type
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