Structural alterations of p(HEMA)--collagen implants.

abstract：:The micro-environment is an important factor in the differentiation of cultured stem cells for the purpose of site specific transplantation. In an attempt to optimize differentiation conditions, co-culture systems composed of both stem cells and primary cells or cell lines were used in hydrogel with in vitro and in vi...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Kim H,Na K,Park KH

更新日期：2010-10-01 00:00:00

abstract：:Scaffold design plays a crucial role in developing graft-based regenerative strategies, especially when intended to be used in a highly ordered nerve tissue. Here we describe a hybrid matrix approach, which combines the structural properties of collagen (type I) with the epitope-presenting ability of peptide amphiphil...

journal_title：Biomaterials

authors： Sur S,Pashuck ET,Guler MO,Ito M,Stupp SI,Launey T

更新日期：2012-01-01 00:00:00

abstract：:Hyaluronic acid (HA) hydrogels have found a wide range of applications in biomedicine: regenerative medicine to drug delivery applications. In vivo quantitative assessment of these hydrogels using magnetic resonance imaging (MRI) provides an effective, accurate, safe, and non-invasive translational approach to assess ...

journal_title：Biomaterials

authors： Shazeeb MS,Corazzini R,Konowicz PA,Fogle R,Bangari DS,Johnson J,Ying X,Dhal PK

更新日期：2018-09-01 00:00:00

abstract：:The potential for base poly(ethylene glycol) graft poly(acrylic acid) PEG-g-PA copolymers and surface-modified PEG-g-PA materials to inhibit random protein fouling and bacterial adhesion are investigated. PEG-g-PA co-polymers were synthesized that inhibited non-specific protein and cellular adhesion. PEG-g-PA co-polym...

journal_title：Biomaterials

authors： Wagner VE,Koberstein JT,Bryers JD

更新日期：2004-05-01 00:00:00

abstract：:Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected ...

journal_title：Biomaterials

authors： Schutte RJ,Xie L,Klitzman B,Reichert WM

更新日期：2009-01-01 00:00:00

abstract：:Injectable scaffolds made of biodegradable biomaterials can stabilize a myocardial infarct and promote cardiac repair. Here, we describe the synthesis of a new, temperature-sensitive, aliphatic polyester hydrogel (HG) conjugated with vascular endothelial growth factor (VEGF) and evaluate its effects on cardiac recover...

journal_title：Biomaterials

authors： Wu J,Zeng F,Huang XP,Chung JC,Konecny F,Weisel RD,Li RK

更新日期：2011-01-01 00:00:00

abstract：:Cytoxicity is an essential concern for polyethyleneimine 25 kDa (PEI 25 kDa), a widely reported, highly effective transfection agent used in gene delivery. In our recent experiments, Small molecular weight cross-linked poly(ethylene imine) by biscarbamate linkage (PEI-Bu) (Mn: 3278, Mw: 4289) can reduce target cell ap...

journal_title：Biomaterials

authors： Xiang S,Su J,Tong H,Yang F,Tong W,Yuan W,Wu F,Wang C,Jin T,Dai K,Zhang X

更新日期：2012-09-01 00:00:00

abstract：:The major problem in skin grafting is that tissue-engineered skin grafts after their transplantation are initially entirely dependent on diffusion. Since this process is slow and inefficient, nutrients, growth factors, and oxygen will insufficiently be supplied and the regenerating graft will undergo a physiological c...

journal_title：Biomaterials

authors： Klar AS,Güven S,Biedermann T,Luginbühl J,Böttcher-Haberzeth S,Meuli-Simmen C,Meuli M,Martin I,Scherberich A,Reichmann E

更新日期：2014-06-01 00:00:00

abstract：:Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...

journal_title：Biomaterials

authors： Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

更新日期：2016-03-01 00:00:00

abstract：:Mussel adhesive proteins (MAPs) have received increased attention as potential environmentally friendly adhesives under aqueous conditions and in medicine. However, attempts to produce functional recombinant MAPs (mainly foot protein type 1, fp-1) by several expression systems have failed. Even though we previously re...

journal_title：Biomaterials

authors： Hwang DS,Gim Y,Yoo HJ,Cha HJ

更新日期：2007-08-01 00:00:00

abstract：:B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal cen...

journal_title：Biomaterials

authors： Roh KH,Song HW,Pradhan P,Bai K,Bohannon CD,Dale G,Leleux J,Jacob J,Roy K

更新日期：2018-05-01 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:The hypothesis that E-selectin on activated endothelial cells could be exploited to selectively target drug delivery systems to tumor vasculature was investigated. HPMA copolymer-doxorubicin (DOX) conjugates displaying the high affinity E-selectin binding peptide (Esbp, primary sequence DITWDQLWDLMK) as targeting liga...

journal_title：Biomaterials

authors： Shamay Y,Paulin D,Ashkenasy G,David A

更新日期：2009-11-01 00:00:00

abstract：:Hydroxyapatite ceramics with zirconia dispersion from fine powders synthesized hydrothermally were post-sintered at 1000-1300 degrees C under 200 MPa of argon for 1 h without capsules, after normal sintering in air at 1200 degrees C for 3 h. Densification was most significant with post-sintering at 1200 degrees C. Fra...

journal_title：Biomaterials

authors： Ioku K,Yoshimura M,Somiya S

更新日期：1990-01-01 00:00:00

abstract：:Construction of bio-mimetic well-organized three-dimensional (3D) tissue with various cells in vitro is one of the ultimate goals of tissue engineering. In particular, fabrication of vasculature in 3D tissue is one of the most important tasks in tissue engineering, because a vascular network is indispensable for almos...

journal_title：Biomaterials

authors： Muraoka M,Shimizu T,Itoga K,Takahashi H,Okano T

更新日期：2013-01-01 00:00:00

abstract：:Simultaneous detection of multiple antigens by conventional immunological methods has been limited by the source of primary antibodies. Each antibody should be derived from a different host species (or subclass of immunoglobulin (Ig)) for suppressing the cross-reactions of secondary antibodies. Here we describe an inn...

journal_title：Biomaterials

authors： Iijima M,Matsuzaki T,Yoshimoto N,Niimi T,Tanizawa K,Kuroda S

更新日期：2011-12-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:Bone marrow-derived cells have demonstrated the ability to differentiate into multiple mesenchymal cell lineages. Here we tested whether smooth muscle (SM)-like tissues can be created in vivo with bone marrow stromal cells (BMSCs). Cultured canine BMSCs, which expressed SM cell-specific markers including SM alpha-acti...

journal_title：Biomaterials

authors： Cho SW,Kim IK,Lim SH,Kim DI,Kang SW,Kim SH,Kim YH,Lee EY,Choi CY,Kim BS

更新日期：2004-07-01 00:00:00

abstract：:Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these ...

journal_title：Biomaterials

authors： Martinez JO,Chiappini C,Ziemys A,Faust AM,Kojic M,Liu X,Ferrari M,Tasciotti E

更新日期：2013-11-01 00:00:00

abstract：:We studied three different types of scaffolds, encapsulating bone morphogenetic protein-2 (BMP-2) plasmid, in terms of their performances in bone regeneration in nude mice. The plasmid was loaded into fibrous matrices in three different ways: coating of naked DNA (Group A) or DNA/chitosan nanoparticles (Group B) onto ...

journal_title：Biomaterials

authors： Nie H,Ho ML,Wang CK,Wang CH,Fu YC

更新日期：2009-02-01 00:00:00

abstract：:In an effort to examine liver injury, immune response, and other physiological effects in mice caused by intragastric administration of nanoparticulate anatase titanium dioxide (5nm), we assessed T lymphocytes, B lymphocyte and NK lymphocyte counts, hematological indices, biochemical parameters of liver functions, and...

journal_title：Biomaterials

authors： Duan Y,Liu J,Ma L,Li N,Liu H,Wang J,Zheng L,Liu C,Wang X,Zhao X,Yan J,Wang S,Wang H,Zhang X,Hong F

更新日期：2010-02-01 00:00:00

abstract：:The study is focused on the evaluation of the potential bioadhesive behaviour of chitosan and thiolated chitosan (chitosan-TBA)-coated poly(isobutyl cyanoacrylates) (PIBCA) nanoparticles. Nanoparticles were obtained by radical emulsion polymerisation with chitosan of different molecular weight and with different propo...

journal_title：Biomaterials

authors： Bravo-Osuna I,Vauthier C,Farabollini A,Palmieri GF,Ponchel G

更新日期：2007-04-01 00:00:00

abstract：:Chitosan coated porous titanium alloy implant (CTI) is demonstrated a promising approach to improve osseointegration capacity of pure porous titanium alloy implant (TI). Since chitosan has been demonstrated to exhibit antioxidant activity, we propose CTI may ameliorate the ROS overproduction, thus reverse the poor oss...

journal_title：Biomaterials

authors： Li X,Ma XY,Feng YF,Ma ZS,Wang J,Ma TC,Qi W,Lei W,Wang L

更新日期：2015-01-01 00:00:00

abstract：:Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...

journal_title：Biomaterials

authors： Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

更新日期：2012-03-01 00:00:00

abstract：:The anodic behaviour of Ni-Cr dental alloys used as porcelain substrates has been investigated in both as-cast and thermal treated conditions. Polarization curves and scratching at constant potentials in synthetic salivas have shown that breakdown potentials are not influenced by the elimination of passive films cover...

journal_title：Biomaterials

authors： de De Micheli SM,Riesgo O

更新日期：1982-10-01 00:00:00

abstract：:Here, we demonstrated dimethyldioctadecylammonium bromide (DODAB), a cationic lipid, bilayer coated Au nanoparticles (AuNPs) could efficiently deliver two types of plasmid DNA into human embryonic kidney cells (HEK 293) in the presence of serum. The transfection efficiency of AuNPs was about five times higher than tha...

journal_title：Biomaterials

authors： Li P,Li D,Zhang L,Li G,Wang E

更新日期：2008-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

journal_title：Biomaterials

authors： Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

更新日期：2017-11-01 00:00:00

abstract：:Cell-extracellular cell matrix (ECM) interactions play a vital role in development including cytoskeletal structure, growth and differentiation. A 15 amino acid, non-RGD containing, peptide that is derived from type I collagen was tested for its ability to confer cell survival. Two routinely utilized bone graft materi...

journal_title：Biomaterials

authors： Hanks T,Atkinson BL

更新日期：2004-08-01 00:00:00

abstract：:In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generall...

journal_title：Biomaterials

authors： Morris DE,Mather ML,Crowe JA

更新日期：2009-09-01 00:00:00

abstract：:To explore molecular mechanism of mediation of adsorbed proteins to cell adhesion and growth on biomaterials, this study examined endothelial cell adhesion, morphology and viability on bare and titanium nitride (TiN) coated nickel titanium (NiTi) alloys and chitosan film firstly, and then identified the type and amoun...

journal_title：Biomaterials

authors： Yang D,Lü X,Hong Y,Xi T,Zhang D

更新日期：2013-07-01 00:00:00