Porous methacrylate scaffolds: supercritical fluid fabrication and in vitro chondrocyte responses.

abstract：:Decellularized native extracellular matrix (ECM) biomaterials are widely used in tissue engineering and have reached clinical application as biomesh implants. To enhance their regenerative properties and postimplantation performance, ECM biomaterials could be functionalized via immobilization of bioactive molecules. T...

journal_title：Biomaterials

authors： Ren X,Evangelista-Leite D,Wu T,Rajab TK,Moser PT,Kitano K,Economopoulos KP,Gorman DE,Bloom JP,Tan JJ,Gilpin SE,Zhou H,Mathisen DJ,Ott HC

更新日期：2018-11-01 00:00:00

abstract：:In human body ascorbic acid plays an essential role in the synthesis and function of skeletal tissues and immune system factors. Ascorbic acid is also a major physiological antioxidant, repairing oxidatively damaged biomolecules, preventing the formation of excessive reactive oxygen species or scavenging these species...

journal_title：Biomaterials

authors： Wang Y,Singh A,Xu P,Pindrus MA,Blasioli DJ,Kaplan DL

更新日期：2006-06-01 00:00:00

abstract：:Previous investigations have found that visible-light (VL)-irradiated camphorquinone (CQ), in the presence of a tertiary amine (e.g., N,N-dimethyl-p-toluidine, DMT), generates reactive oxygen species and causes oxidative DNA damage in vitro. In this study, oxidative DNA damage produced by VL-irradiated CQ/DMT, in the ...

journal_title：Biomaterials

authors： Winter K,Pagoria D,Geurtsen W

更新日期：2005-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biomaterials

authors： Kyle S,McPherson MJ,Aggeli A,Ingham E

更新日期：2011-07-01 00:00:00

abstract：:Previously we demonstrated the ability of ethyl glycinato substituted polyphosphazenes to neutralize the acidic degradation products and control the degradation rate of poly(lactic acid-glycolic acid) (PLAGA) by blending. In this study, blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazen...

journal_title：Biomaterials

authors： Deng M,Nair LS,Nukavarapu SP,Kumbar SG,Jiang T,Krogman NR,Singh A,Allcock HR,Laurencin CT

更新日期：2008-01-01 00:00:00

abstract：:In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modif...

journal_title：Biomaterials

authors： Yli-Urpo H,Närhi M,Närhi T

更新日期：2005-10-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Severe wear of the ultra-high molecular weight polyethylene (UHMWPE) components of total joint replacements limits their long-term success. In previous studies, the infrared spectra obtained on retrieved UHMWPE components were interpreted as evidence that the UHMWPE oxidizes in vivo. In direct contrast, infrared spect...

journal_title：Biomaterials

authors： James SP,Blazka S,Merrill EW,Jasty M,Lee KR,Bragdon CR,Harris WH

更新日期：1993-07-01 00:00:00

abstract：:Ectopic transplantation of islets provides a beta cell-replacement approach that may allow the recovery of physiological regulation of the blood sugar level in patients with Type I diabetes (T1D). In development of new extrahepatic islet transplantation protocols in support of the islet engraftment, it is pivotal to d...

journal_title：Biomaterials

authors： Wang X,Wang K,Zhang W,Qiang M,Luo Y

更新日期：2017-09-01 00:00:00

abstract：:Fibrous polyurethane (FPU) prostheses with or without fibronectin coating and gelatin impregnation and FPU prostheses with or without fibronectin coating were seeded with 4.8 x 10(5) subcultivated dog endothelial cells per cm2 prosthesis. Expanded polytetrafluoroethylene (ePTFE) prostheses with and without fibronectin...

journal_title：Biomaterials

authors： Hess F,Jerusalem R,Reijnders O,Jerusalem C,Steeghs S,Braun B,Grande P

更新日期：1992-01-01 00:00:00

abstract：:This study was designed to examine the adhesion, proliferation, and morphology of chondrocytes on new scaffolds; and to examine these cells histologically for the ability of the chondrocytes to maintain chondrogenic properties after subcutaneous implantation into nude mice. Both 75:25 poly (L-lactide-co-epsilon-caprol...

journal_title：Biomaterials

authors： Honda M,Morikawa N,Hata K,Yada T,Morita S,Ueda M,Kimata K

更新日期：2003-09-01 00:00:00

abstract：:Wound dressing is critical important for cutaneous wound healing. However, the application of current products is limited due to poor mechanical property, unsuitable water vapor transmission rate (WVTR), poor anti-infective property or poor biocompatibility, etc. In the present study, a microporous silicone rubber mem...

journal_title：Biomaterials

authors： Xu R,Luo G,Xia H,He W,Zhao J,Liu B,Tan J,Zhou J,Liu D,Wang Y,Yao Z,Zhan R,Yang S,Wu J

更新日期：2015-02-01 00:00:00

abstract：:Nervous tissue lesions are an important social concern due to their increasing prevalence and their high sanitary costs. Their treatment still remains a challenge because of the reduced ability of nervous tissue to regenerate, its intrinsic structural and functional complexity and the rapid formation of fibroglial sca...

journal_title：Biomaterials

authors： Serrano MC,Nardecchia S,García-Rama C,Ferrer ML,Collazos-Castro JE,del Monte F,Gutiérrez MC

更新日期：2014-02-01 00:00:00

abstract：:Implantation of skeletal myoblasts to the heart has been investigated as a means to regenerate and protect the myocardium from damage after myocardial infarction. While several animal studies utilizing skeletal myoblasts have reported positive findings, results from clinical studies have been mixed. In this study we u...

journal_title：Biomaterials

authors： McGinn AN,Nam HY,Ou M,Hu N,Straub CM,Yockman JW,Bull DA,Kim SW

更新日期：2011-01-01 00:00:00

abstract：:Understanding how engineered tissue scaffold architecture affects cell morphology, metabolism, phenotypic expression, as well as predicting material mechanical behavior has recently received increased attention. In the present study, an image-based analysis approach that provides an automated tool to characterize engi...

journal_title：Biomaterials

authors： D'Amore A,Stella JA,Wagner WR,Sacks MS

更新日期：2010-07-01 00:00:00

abstract：:Sub-micron particles of bioactive glass (SMBGs) with composition 85 mol% SiO(2) and 15 mol% CaO were synthesised and characterised. Bioactivity was demonstrated by the formation of calcium apatite following 5 days immersion in simulated body fluid (SBF). The effect of a 24 h exposure of SMBGs (100 μg/ml, 150 μg/ml, 20...

journal_title：Biomaterials

authors： Labbaf S,Tsigkou O,Müller KH,Stevens MM,Porter AE,Jones JR

更新日期：2011-02-01 00:00:00

abstract：:Tissue-engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue-engineered constructs, typically causing them to fail. Two components of FBR are an inflammatory response and a lac...

journal_title：Biomaterials

authors： Browne S,Monaghan MG,Brauchle E,Berrio DC,Chantepie S,Papy-Garcia D,Schenke-Layland K,Pandit A

更新日期：2015-11-01 00:00:00

abstract：:The aim of this study was to develop a new diagnostic and therapeutic approach for the treatment of osteoporosis. Previously, we demonstrated that intraosseous transplantation of platelet-rich plasma (PRP) treated-osteoblast-like cells into ovariectomized senescence-accelerated mice (OVX-SAMP8) prevented the developme...

journal_title：Biomaterials

authors： Liu HY,Wu AT,Tsai CY,Chou KR,Zeng R,Wang MF,Chang WC,Hwang SM,Su CH,Deng WP

更新日期：2011-10-01 00:00:00

abstract：:Electrically conducting polymers hold promise for developing advanced neuroprostheses, bionic systems and neural repair devices. Among them, poly(3, 4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) exhibits superior physicochemical properties but biocompatibility issues have limited its use. We d...

journal_title：Biomaterials

authors： Collazos-Castro JE,Polo JL,Hernández-Labrado GR,Padial-Cañete V,García-Rama C

更新日期：2010-12-01 00:00:00

abstract：:The shelf life of implantable materials has rarely been addressed. We determined whether osteoconductivity of titanium is stable over time. Rat bone marrow-derived osteoblasts were cultured on new titanium disks (immediately after acid-etching), 3-day-old (stored after acid-etching for 3 days in dark ambient condition...

journal_title：Biomaterials

authors： Att W,Hori N,Takeuchi M,Ouyang J,Yang Y,Anpo M,Ogawa T

更新日期：2009-10-01 00:00:00

abstract：:Peri-implant bone formation depends on the ability of mesenchymal cells to colonize the implant surface and differentiate into osteoblasts. Human mesenchymal stem cells (HMSCs) undergo osteoblastic differentiation on microstructured titanium (Ti) surfaces in the absence of exogenous factors, but the mechanisms are unk...

journal_title：Biomaterials

authors： Olivares-Navarrete R,Hyzy SL,Park JH,Dunn GR,Haithcock DA,Wasilewski CE,Boyan BD,Schwartz Z

更新日期：2011-09-01 00:00:00

abstract：:Designing biomaterial scaffolds remains a major challenge in tissue engineering. Key to this challenge is improved understanding of the relationships between the scaffold properties and its degradation kinetics, as well as the cell interactions and the promotion of new matrix deposition. Here we present the use of non...

journal_title：Biomaterials

authors： Rice WL,Firdous S,Gupta S,Hunter M,Foo CW,Wang Y,Kim HJ,Kaplan DL,Georgakoudi I

更新日期：2008-05-01 00:00:00

abstract：:Following our recent report of attractive antibacterial properties of a designed amphiphilic peptide, A(9)K, we have investigated its antitumor activities by examining the modes of its action against different mammalian cell types. The peptide strongly inhibited the growth of cancerous HeLa cells and human promyelocyt...

journal_title：Biomaterials

authors： Xu H,Chen CX,Hu J,Zhou P,Zeng P,Cao CH,Lu JR

更新日期：2013-04-01 00:00:00

abstract：:High throughput cellular studies require small sample volume to reduce costs and enhance sensitivity. Microfluidics-generated water-in-oil (W/O) single emulsion droplet systems, in particular, provide uniform, well defined and discrete microenvironment for cell culture, screening, and sorting. However, these single em...

journal_title：Biomaterials

authors： Zhang Y,Ho YP,Chiu YL,Chan HF,Chlebina B,Schuhmann T,You L,Leong KW

更新日期：2013-06-01 00:00:00

abstract：:In order to develop a more effective self-etching primer, with a longer lasting shelf life, we designed a self-etching primer comprised of methacrylamide, N-methacryloyl glycine, NMGly. In this study, the hydrolytic stability of the amide portion in the NMGly was examined. The difference in the hydrolytic stability be...

journal_title：Biomaterials

authors： Nishiyama N,Suzuki K,Yoshida H,Teshima H,Nemoto K

更新日期：2004-03-01 00:00:00

abstract：:Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chrom...

journal_title：Biomaterials

authors： Puntel A,Maeda A,Golczak M,Gao SQ,Yu G,Palczewski K,Lu ZR

更新日期：2015-03-01 00:00:00

abstract：:Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties,...

journal_title：Biomaterials

authors： Walsh WR,Guzelsu N

更新日期：1994-01-01 00:00:00

abstract：:Reconstruction of the genitourinary tract, using engineered urological tissues, requires a mechanically stable biodegradable and biocompatible scaffold and cultured cells. Such engineered autologous tissue would have many clinical implications. In this study a highly porous biodegradable polyesterurethane-foam, DegraP...

journal_title：Biomaterials

authors： Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

更新日期：2006-03-01 00:00:00

abstract：:Anti-VEGF drugs that are used in conjunction with laser ablation to treat patients with diabetic retinopathy suffer from short half-lives in the vitreous of the eye resulting in the need for frequent intravitreal injections. To improve the intravitreal half-life of anti-VEGF drugs, such as the VEGF decoy receptor sFlt...

journal_title：Biomaterials

authors： Altiok EI,Santiago-Ortiz JL,Svedlund FL,Zbinden A,Jha AK,Bhatnagar D,Loskill P,Jackson WM,Schaffer DV,Healy KE

更新日期：2016-07-01 00:00:00

abstract：:We developed cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC), to enable corneal regeneration by endogenous cell recruitment, to address the worldwide shortage of donor corneas. Patients were grafted with RHC implants. Over four years, the regenerated neo-corneas were stably int...

journal_title：Biomaterials

authors： Fagerholm P,Lagali NS,Ong JA,Merrett K,Jackson WB,Polarek JW,Suuronen EJ,Liu Y,Brunette I,Griffith M

更新日期：2014-03-01 00:00:00