Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold.

abstract：:Magnetic microcarrier particles useful for delivering chemotherapeutic drug molecules are described. The particles are formed by joint deformation of iron and carbon in a ball mill. Physical, chemical, and functional characterization has been carried out on the particles. Physical characteristics include microscopy, p...

journal_title：Biomaterials

authors： Rudge SR,Kurtz TL,Vessely CR,Catterall LG,Williamson DL

更新日期：2000-07-01 00:00:00

abstract：:Poly(3, 4-ethylenedioxythiophene)-coated carbon microfibers (PEDOT-MFs) hold promise for developing advanced neuroprostheses and neural repair devices. We investigated the chronic cellular responses to PEDOT-MFs implanted into the uninjured and the transected rat spinal cord, and compared the effects of polymer surfac...

journal_title：Biomaterials

authors： Alves-Sampaio A,García-Rama C,Collazos-Castro JE

更新日期：2016-05-01 00:00:00

abstract：:Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...

journal_title：Biomaterials

authors： van Mullem PJ,Vaandrager JM,Nicolai JP,de Wijn JR

更新日期：1990-07-01 00:00:00

abstract：:Current advances in stem cell biology have brought much hope for therapy of neuro-degenerative diseases. However, neural stem cells (NSCs) are rare adult stem cells, and the use of non-NSCs requires efficient and high-yielding lineage-specific differentiation prior to transplantation for efficacy. We report on the eff...

journal_title：Biomaterials

authors： Wang CH,Wu CC,Hsu SH,Liou JY,Li YW,Wu KK,Lai YK,Yen BL

更新日期：2013-04-01 00:00:00

abstract：:Cell delivery in cell therapy is typically challenged by the low cell survival rate and immunological rejection during cells injection and circulation. Encapsulation of cells with semipermeable hydrogels or membranes can improve cell viability by resisting high shear force and inhibit immune response with the physical...

journal_title：Biomaterials

authors： Yang J,Yang Y,Kawazoe N,Chen G

更新日期：2019-03-01 00:00:00

abstract：:A comprehensive strategy for the preparation of mulberry-like dual-drug complicated nanocarriers (MLDC NCs) with high drug loading and adjustable dual-drug ratio was developed. First, apogossypolone (ApoG2) amphiphilic starch micelles (AASt MCs) were prepared by self-assembly process, and doxorubicin (DOX) hyaluronic ...

journal_title：Biomaterials

authors： Li K,Liu H,Gao W,Chen M,Zeng Y,Liu J,Xu L,Wu D

更新日期：2015-01-01 00:00:00

abstract：:We previously reported that modification of GALA peptide on the surface of liposomes enhanced fusion with endosomal membrane, and cytoplasmic release of encapsulated macromolecules. We report herein that an additional coating of GALA-modified liposomes with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer result...

journal_title：Biomaterials

authors： Ukawa M,Akita H,Masuda T,Hayashi Y,Konno T,Ishihara K,Harashima H

更新日期：2010-08-01 00:00:00

abstract：:Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymeri...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Takatori Y,Kawaguchi H,Nakamura K,Ishihara K

更新日期：2010-02-01 00:00:00

abstract：:Topographical features on the nanometer scale are known to influence cellular behavior. The response of specific cell types to various types of surface structures is currently still being investigated. Alumina ceramics play an important role as biomaterials, e.g., in medical and dental applications. In this study, we ...

journal_title：Biomaterials

authors： Wittenbrink I,Hausmann A,Schickle K,Lauria I,Davtalab R,Foss M,Keller A,Fischer H

更新日期：2015-09-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:The authors aimed to develop a liquid material for embolization of aneurysms. In vitro and in vivo performances of the new embolic material were examined by cell culture and using an aneurysm model made in common carotid arteries (CCAs) of adult rats. Engineered protein ProNectin F (PnF), which contains 13 sites of an...

journal_title：Biomaterials

authors： Ohyama T,Ko IK,Miura A,Iwata H,Taki W

更新日期：2004-08-01 00:00:00

abstract：:RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

journal_title：Biomaterials

authors： Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of...

journal_title：Biomaterials

authors： Rajabi S,Pahlavan S,Ashtiani MK,Ansari H,Abbasalizadeh S,Sayahpour FA,Varzideh F,Kostin S,Aghdami N,Braun T,Baharvand H

更新日期：2018-02-01 00:00:00

abstract：:Random copolymers of trimethylene carbonate and epsilon-caprolactone have been synthesized through ring-opening polymerization using rare earth alkoxides as initiator. The structure of the copolymers has been characterized by 1H and 13C NMR. Their thermal behaviour, their permeability to liquid and their mechanical pr...

journal_title：Biomaterials

authors： Schappacher M,Fabre T,Mingotaud AF,Soum A

更新日期：2001-11-01 00:00:00

abstract：:In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room te...

journal_title：Biomaterials

authors： Migneco F,Huang YC,Birla RK,Hollister SJ

更新日期：2009-11-01 00:00:00

abstract：:Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth factor is known to enhance chondrocyte differentiation and endochondral ossification during development, yet whether PGRN also plays a role in bone regeneration remains un...

journal_title：Biomaterials

authors： Zhao YP,Tian QY,Frenkel S,Liu CJ

更新日期：2013-09-01 00:00:00

abstract：:Polylactide (PLA) microspheres were coated with collagen for cell culture and injectable cell carriers. Utilizing a method of emulsion-solvent evaporation, PLA microspheres with diameter ranging from 180 to 280 microm were prepared, followed with aminolysis in hexanediamine/n-propanol solution to introduce free amino ...

journal_title：Biomaterials

authors： Hong Y,Gao C,Xie Y,Gong Y,Shen J

更新日期：2005-11-01 00:00:00

abstract：:Bone substitutes of bovine origin are widely used for treatment of bone defects in dental and orthopedic surgery. Due to the occurrence of BSE and the new variant of Creutzfeldt Jakob Disease risks of transmitting diseases through the use of such materials need to be carefully evaluated. Risk analysis can either be ba...

journal_title：Biomaterials

authors： Wenz B,Oesch B,Horst M

更新日期：2001-06-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have anti-cancer effect. However, whether and how these particles could inhibit the growth of acute myeloid leukemia (AML) cells is unclear. In the present study, we prepared AgNPs with various sizes and investigated their cytotoxic effect on AML cells. We found that AgNPs could inhibit th...

journal_title：Biomaterials

authors： Guo D,Zhu L,Huang Z,Zhou H,Ge Y,Ma W,Wu J,Zhang X,Zhou X,Zhang Y,Zhao Y,Gu N

更新日期：2013-10-01 00:00:00

abstract：:We report a novel silk-gold nanocomposite based nerve conduit successfully tested in a neurotmesis grade sciatic nerve injury model in rats over a period of eighteen months. The conduit was fabricated by adsorbing gold nanoparticles onto silk fibres and transforming them into a nanocomposite sheet by electrospinning w...

journal_title：Biomaterials

authors： Das S,Sharma M,Saharia D,Sarma KK,Sarma MG,Borthakur BB,Bora U

更新日期：2015-09-01 00:00:00

abstract：:Biodegradable and non-biodegradable polymers represent promising materials for sustained protein delivery systems. However, structural protein instabilities due to interactions with the polymer surface are often observed. Aim of the present study was to analyze and predict these instabilities by determination of adsor...

journal_title：Biomaterials

authors： Seidel N,Sitterberg J,Vornholt W,Bakowsky U,Keusgen M,Kissel T

更新日期：2012-02-01 00:00:00

abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

journal_title：Biomaterials

authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the ...

journal_title：Biomaterials

authors： Grunkemeier JM,Tsai WB,McFarland CD,Horbett TA

更新日期：2000-11-01 00:00:00

abstract：:To investigate the roles of composition and characteristics of titanium surface oxides in cellular behaviour of osteoblasts, the surface oxides of titanium were modified in composition and topography by anodic oxidation in two kinds of electrolytes, (a) 0.2 M H(3)PO(4), and (b) 0.03 M calcium glycerophosphate (Ca-GP) ...

journal_title：Biomaterials

authors： Zhu X,Chen J,Scheideler L,Reichl R,Geis-Gerstorfer J

更新日期：2004-08-01 00:00:00

abstract：:The native retinal pigment epithelium (RPE) exists as a monolayer structure and is critically involved in the maintenance of photoreceptors. Damage or destruction of the RPE due to a variety of diseases therefore often results in loss of vision. With regenerative purposes in mind, we have examined various culture cond...

journal_title：Biomaterials

authors： Kubota A,Nishida K,Yamato M,Yang J,Kikuchi A,Okano T,Tano Y

更新日期：2006-07-01 00:00:00

abstract：:Ferroptosis, a newfound non-apoptotic cell death pathway, results from the accumulation of iron-dependent lipid peroxide (LPO). Recently, emerging iron-based nanomaterials have been extensively developed to induce Fenton reaction-dependent ferroptosis for cancer therapy. However, insufficient amount of H2O2 and limite...

journal_title：Biomaterials

authors： He YJ,Liu XY,Xing L,Wan X,Chang X,Jiang HL

更新日期：2020-05-01 00:00:00

abstract：:Site specific targeting remains elusive for gene and stem cell therapies in the cardiovascular field. One promising option involves use of devices that deliver larger and more sustained cell/gene payloads to specific disease sites using the versatility of percutaneous vascular access technology. Smooth muscle cells (S...

journal_title：Biomaterials

authors： Kumar AH,Martin K,Doyle B,Huang CL,Pillai GK,Ali MT,Skelding KA,Wang S,Gleeson BM,Jahangeer S,Ritman EL,Russell SJ,Caplice NM

更新日期：2014-10-01 00:00:00

abstract：:Mesoporous silica (MPS), synthesized via the supramolecular polymer templating method, is one of the most attractive nanomaterials for biomedical applications, such as drug delivery systems, labeling, and tissue engineering. The significant difference between MPS and general silica (colloidal silica) is the pore archi...

journal_title：Biomaterials

authors： Lee S,Yun HS,Kim SH

更新日期：2011-12-01 00:00:00

abstract：:We prepared copper/low-density polyethylene (LDPE) nanocomposites with various mass fractions of copper nanoparticles and investigated the Cu(2+) release rate of them for 220 days in a simulated uterine solution .The influences of copper nanoparticle mass fraction on Cu(2+) release and volume resistivity confirm that ...

journal_title：Biomaterials

authors： Cai S,Xia X,Xie C

更新日期：2005-05-01 00:00:00

abstract：:The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer vaccines, as they c...

journal_title：Biomaterials

authors： Molino NM,Neek M,Tucker JA,Nelson EL,Wang SW

更新日期：2016-04-01 00:00:00