Intravascular cell delivery device for therapeutic VEGF-induced angiogenesis in chronic vascular occlusion.

abstract：:We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive c...

journal_title：Biomaterials

authors： Navarro JR,Lerouge F,Cepraga C,Micouin G,Favier A,Chateau D,Charreyre MT,Lanoë PH,Monnereau C,Chaput F,Marotte S,Leverrier Y,Marvel J,Kamada K,Andraud C,Baldeck PL,Parola S

更新日期：2013-11-01 00:00:00

abstract：:Collagen, type I, is a highly abundant natural protein material which has been cross-linked by a variety of methods including chemical agents, physical heating and UV irradiation with the aim of enhancing its physical characteristics such as mechanical strength, thermal stability, resistance to proteolytic breakdown, ...

journal_title：Biomaterials

authors： Chau DY,Collighan RJ,Verderio EA,Addy VL,Griffin M

更新日期：2005-11-01 00:00:00

abstract：:Nano-scale modification of a segmented polyurethane (SPU) with cross-linked 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was performed to obtain a biocompatible elastomer. To control the domain size and the depth of the modified layer, various compositions of monomers, including MPC, 2-ethylhexyl methacrylat...

journal_title：Biomaterials

authors： Morimoto N,Watanabe A,Iwasaki Y,Akiyoshi K,Ishihara K

更新日期：2004-10-01 00:00:00

abstract：:A lipid/calcium/phosphate (LCP) nanoparticle (NP) formulation (particle diameter ∼25 nm) with superior siRNA delivery efficiency was developed and reported previously. Here, we describe the successful formulation of (111)In into LCP for SPECT/CT imaging. Imaging and biodistribution studies showed that, polyethylene gl...

journal_title：Biomaterials

authors： Tseng YC,Xu Z,Guley K,Yuan H,Huang L

更新日期：2014-05-01 00:00:00

abstract：:Bone marrow-derived cells have demonstrated the ability to differentiate into multiple mesenchymal cell lineages. Here we tested whether smooth muscle (SM)-like tissues can be created in vivo with bone marrow stromal cells (BMSCs). Cultured canine BMSCs, which expressed SM cell-specific markers including SM alpha-acti...

journal_title：Biomaterials

authors： Cho SW,Kim IK,Lim SH,Kim DI,Kang SW,Kim SH,Kim YH,Lee EY,Choi CY,Kim BS

更新日期：2004-07-01 00:00:00

abstract：:The biopolymer DNA allows to create nanoscale, biocompatible structures, which can be designed in a target-specific and stimuli-responsive manner. DNA carrier systems with these characteristics hold a great potential for nanomedical applications, such as for the treatment of inflammatory diseases. Here we used a DNA-b...

journal_title：Biomaterials

authors： Sellner S,Kocabey S,Zhang T,Nekolla K,Hutten S,Krombach F,Liedl T,Rehberg M

更新日期：2017-07-01 00:00:00

abstract：:The purpose of this study was to determine the mechanical properties and the atomistic structures of various gelatin hydrogels as a preliminary to using these in bioengineering applications. The hydrogels were investigated as neat materials and as particulate-reinforced composites both in the as-formed state and follo...

journal_title：Biomaterials

authors： Usta M,Piech DL,MacCrone RK,Hillig WB

更新日期：2003-01-01 00:00:00

abstract：:A-B-type block copolymers, consisting of polystyrene (PST) or poly(methyl methacrylate) (PMMA) forming segment (A) and poly(gamma-benzyl L-glutamate) (P[Glu(OBzl)]) segment (B), were synthesized and the thrombus formation on these block copolymer films was investigated in relation to the adsorption of plasma proteins ...

journal_title：Biomaterials

authors： Mori A,Ito Y,Sisido M,Imanishi Y

更新日期：1986-09-01 00:00:00

abstract：:Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loa...

journal_title：Biomaterials

authors： Xu C,Chen F,Valdovinos HF,Jiang D,Goel S,Yu B,Sun H,Barnhart TE,Moon JJ,Cai W

更新日期：2018-05-01 00:00:00

abstract：:Nanofiber scaffold-mediated delivery of small-interfering RNA (siRNA) holds great potential in regenerative medicine by providing biomimicking topographical signals and enhanced gene silencing effects to seeded cells. While the delivery of naked siRNA was demonstrated previously using poly (ε-caprolactone) (PCL) nanof...

journal_title：Biomaterials

authors： Rujitanaroj PO,Wang YC,Wang J,Chew SY

更新日期：2011-09-01 00:00:00

abstract：:Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no...

journal_title：Biomaterials

authors： Helle J,Barr J,Ng SY,Shen HR,Schwach-Abdellaoui K,Gurny R,Vivien-Castioni N,Loup PJ,Baehni P,Mombelli A

更新日期：2002-11-01 00:00:00

abstract：:AuCu and AuAg alloys (30 at. % Au) have been immersed in aqueous solutions of chloride and sulphide with additions of protein (mucin). The surfaces of the alloys were subsequently analysed by means of ESCA and compared with previous and similar tests without addition of mucin. No noticeable effect of the mucin additio...

journal_title：Biomaterials

authors： Herø H,Hultquist G,Odén A

更新日期：1985-11-01 00:00:00

abstract：:Radiolabeled nanomaterials, especially those with ultra-small structures, have been the research focus in recent years, and thus may open up new prospects for clinical diseases theranostics. Herein, fluorinated Pd nanosheets labeled with Gd or radionuclides are developed as multimodal platforms for tumor theranostics....

journal_title：Biomaterials

authors： Guo Z,Chen M,Peng C,Mo S,Shi C,Fu G,Wen X,Zhuang R,Su X,Liu T,Zheng N,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:In vitro tissue engineered models are poised to have significant impact on disease modeling and preclinical drug development. Reliable methods to induce microvascular networks in such microphysiological systems are needed to improve the size and physiological function of these models. By systematically engineering sev...

journal_title：Biomaterials

authors： Brown A,He H,Trumper E,Valdez J,Hammond P,Griffith LG

更新日期：2020-06-01 00:00:00

abstract：:CD47, a "don't eat me" signal, is over-expressed on the surface of most tumors that interacts with signal regulatory protein α (SIRPα) on phagocytic cells. By engaging SIRPα, CD47 limits the ability of macrophages to engulf tumor cells, which acts as a major phagocytic barrier. In this study, we developed an exosome-b...

journal_title：Biomaterials

authors： Koh E,Lee EJ,Nam GH,Hong Y,Cho E,Yang Y,Kim IS

更新日期：2017-03-01 00:00:00

abstract：:A tissue-engineered substitute that facilitates large-volume regeneration of the subcutaneous adipose tissue layer is needed for reconstructive plastic surgery. Towards this goal, we describe the in vitro culture of primary human adipose-derived stem cells (ASC) seeded into placental decellular matrix (PDM) and cross-...

journal_title：Biomaterials

authors： Flynn LE,Prestwich GD,Semple JL,Woodhouse KA

更新日期：2008-04-01 00:00:00

abstract：:Thermostimulated current spectroscopy has been applied to the investigation of molecular mobility in human calcified tissue. A comparative study of extracts at various stages of demineralization is presented. The response of an organic-mineral complex interphase has been identified. ...

journal_title：Biomaterials

authors： Martin M,Lamure A,Lacabanne C,Betin C,Harmand MF

更新日期：1990-07-01 00:00:00

abstract：:Surface properties of poly (D,L-lactide) (PDLLA) were modified by combining plasma treatment and collagen modification. The changes of surface properties were characterized by contact angles, surface energy, X-ray photoelectron spectra and scanning electron microscopy. The mouse 3T3 fibroblasts were used as model cell...

journal_title：Biomaterials

authors： Yang J,Bei J,Wang S

更新日期：2002-06-01 00:00:00

abstract：:Hydroxyapatite (HA) in 25%, 50% and 75% w/w fractions was incorporated into chitin solutions and processed into air- and freeze-dried materials. These HA-chitin materials were exposed to cell cultures and implanted into the intramusculature of a rat model. The HA-chitin materials were found to be non-cytotoxic and deg...

journal_title：Biomaterials

authors： Ge Z,Baguenard S,Lim LY,Wee A,Khor E

更新日期：2004-03-01 00:00:00

abstract：:This article introduces novel biocompatible tissue adhesives that do not involve any chemical or biochemical reactions, during their application in vivo. The use of these new adhesives is based exclusively on their temperature-dependent rheological properties. Since biocompatibility and biodegradability are additional...

journal_title：Biomaterials

authors： Cohn D,Lando G

更新日期：2004-12-01 00:00:00

abstract：:Microstructure of thermal sprayed hydroxyapatite (HA) splats was characterized using transmission electron microscopy (TEM), and the formation mechanisms of micropores within the splats were investigated with the aid of simulated body fluids (SBF). High-velocity oxy-fuel and direct current (DC) plasma spray techniques...

journal_title：Biomaterials

authors： Li H,Khor KA,Cheang P

更新日期：2004-08-01 00:00:00

abstract：:To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and soluti...

journal_title：Biomaterials

authors： Badiger MV,McNeill ME,Graham NB

更新日期：1993-11-01 00:00:00

abstract：:This article reports a novel preparation method of poly(ethylene glycol) (PEG)-polystyrene (PST) amphiphilic block copolymers with well-defined block lengths by using photopolymerization of an iniferter, benzyl N,N-diethyldithiocarbamate. PEG macroiniferters, which were prepared by end-capping of PEG monomethyl ethers...

journal_title：Biomaterials

authors： Nakayama Y,Miyamura M,Hirano Y,Goto K,Matsuda T

更新日期：1999-05-01 00:00:00

abstract：:Human stem cells are vulnerable to unfavorable conditions, and their transportation relies on costly and inconvenient cryopreservation. We report here that human mesenchymal stem cells (MSC) in spheroids survived ambient conditions (AC) many days longer than in monolayer. Under AC, the viability of MSC in spheroids re...

journal_title：Biomaterials

authors： Jiang B,Yan L,Miao Z,Li E,Wong KH,Xu RH

更新日期：2017-07-01 00:00:00

abstract：:Nanomedicine options for colon cancer therapy have been limited by the lack of suitable carriers capable of delivering sufficient drug into tumors to cause lethal toxicity. To circumvent this limitation, we fabricated a camptothecin (CPT)-loaded poly(lactic-co-glycolic acid) nanoparticle (NP) with dual-surface functio...

journal_title：Biomaterials

authors： Xiao B,Zhang M,Viennois E,Zhang Y,Wei N,Baker MT,Jung Y,Merlin D

更新日期：2015-04-01 00:00:00

abstract：:We report the synthesis and characterization of dendrimer-entrapped gold nanoparticles (Au DENPs) modified by polyethylene glycol (PEG) with enhanced biocompatibility for computed tomography (CT) imaging applications. In this study, amine-terminated poly(amidoamine) dendrimers of generation 5 (G5.NH(2)) modified by PE...

journal_title：Biomaterials

authors： Peng C,Zheng L,Chen Q,Shen M,Guo R,Wang H,Cao X,Zhang G,Shi X

更新日期：2012-02-01 00:00:00

abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

journal_title：Biomaterials

authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

更新日期：2011-10-01 00:00:00

abstract：:We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (-) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells and a DUP-1 peptide aptamer specific to PSMA (-) cells were conjugated through streptavidin. Doxorubicin-loaded onto the ste...

journal_title：Biomaterials

authors： Min K,Jo H,Song K,Cho M,Chun YS,Jon S,Kim WJ,Ban C

更新日期：2011-03-01 00:00:00

abstract：:Literature has shown that slowing down the curing rate of light-initiated resin composites by lowering the light intensity of the light source improved the integrity of the adhesive composite-cavity interface as a result of a more gradual contraction stress development. This study investigated how the curing rate coul...

journal_title：Biomaterials

authors： Venhoven BA,de Gee AJ,Davidson CL

更新日期：1996-12-01 00:00:00

abstract：:Keratins are a family of structural proteins that can be isolated from a variety of tissues. "Soft" keratins are cytoskeletal elements found in epithelial tissues while protective tissues such as nails, hooves, and hair are composed of "hard" keratins. Hard keratins have been the subject of biomaterials investigations...

journal_title：Biomaterials

authors： Hill P,Brantley H,Van Dyke M

更新日期：2010-02-01 00:00:00