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Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials.

Abstract：

:The shelf life of implantable materials has rarely been addressed. We determined whether osteoconductivity of titanium is stable over time. Rat bone marrow-derived osteoblasts were cultured on new titanium disks (immediately after acid-etching), 3-day-old (stored after acid-etching for 3 days in dark ambient conditions), 2-week-old, and 4-week-old disks. Protein adsorption capacity, and osteoblast migration, attachment, spread, proliferation and mineralization decreased substantially on old titanium surfaces in an age-dependent manner. When the 4-week-old implants were placed into rat femurs, the biomechanical strength of bone-titanium integration was less than half that for newly processed implants at the early healing stage. More than 90% of the new implant surface was covered by newly generated bone compared to 58% for 4-week-old implants. This time-dependent biological degradation was also found for machined and sandblasted titanium surfaces and was associated with progressive accumulation of hydrocarbon on titanium surfaces. The new surface could attract osteoblasts even under a protein-free condition, but its high bioactivity was abrogated by masking the surface with anions. These results uncover an aging-like time-dependent biological degradation of titanium surfaces from bioactive to bioinert. We also suggest possible underlying mechanisms for this biological degradation that provide new insights into how we could inadvertently lose, and conversely, maximize the osteoconductivity of titanium-based implant materials.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Att W,Hori N,Takeuchi M,Ouyang J,Yang Y,Anpo M,Ogawa T

doi

10.1016/j.biomaterials.2009.06.040

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

5352-63

issue

29

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(09)00645-0

journal_volume

30

pub_type

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