Abstract:
:Distearoylphophatidylcholine (DSPC) mixed with various mole percentages of polyethylene oxide (number average molecular weight 2000)-grafted distearoylphosphatidylethanolamine (PEO2000-DSPE) were deposited on DSPE-coated quartz surfaces by the Langmuir-Blodgett deposition. Structural transitions in PEO2000 from pancake to mushroom, and from mushroom to brush conformations were revealed from film balance experiments. Adsorption kinetics of proteins from 1% platelet-poor plasma (PPP) on the supported lipid bilayers were studied using intrinsic total internal reflection fluorescence. All the supported lipid bilayers exhibited over a magnitude reduction in adsorbed plasma proteins, compared with the quartz substrate. The increase of PEO2000-DSPE density in the mixed bilayers slightly increases the amount of adsorbed proteins on the bilayers.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Xu Z,Marchant REdoi
10.1016/s0142-9612(00)00004-1keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
1075-83issue
10eissn
0142-9612issn
1878-5905pii
S0142-9612(00)00004-1journal_volume
21pub_type
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