Anticoagulant activity of amino acid modified polystyrene resins: influence of the carboxylic acid function.

abstract：:In mammalian embryos, cortical interneurons travel long distances among complex three-dimensional tissues before integrating into cortical circuits. Several molecular guiding cues involved in this migration process have been identified, but the influence of physical parameters remains poorly understood. In the present...

journal_title：Biomaterials

authors： Leclech C,Renner M,Villard C,Métin C

更新日期：2019-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that affects more than 1 million individuals in the USA. Local therapy with enema formulations, such as micronized budesonide (Entocort®), is a common strategy for treating patients with distally active IBD. However, we hypothesize th...

journal_title：Biomaterials

authors： Date AA,Halpert G,Babu T,Ortiz J,Kanvinde P,Dimitrion P,Narayan J,Zierden H,Betageri K,Musmanno O,Wiegand H,Huang X,Gumber S,Hanes J,Ensign LM

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to access tissue reactions to the outer prismatic (prism) and the inner nacreous (nacre) layers of the fresh water Margaritifera shell. The materials, in granule form, were implanted into the back muscles and femurs of rats for 1, 2, 4, 8 and 16 weeks. In the back muscles, a foreign body ...

journal_title：Biomaterials

authors： Liao H,Mutvei H,Sjöström M,Hammarström L,Li J

更新日期：2000-03-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect vertebrates by killing infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB-induced apoptosis of target cells causes inflammatory disease and chronic transplant rejection and so is an important disease target. The aim...

journal_title：Biomaterials

authors： Cheng W,Yang C,Hedrick JL,Williams DF,Yang YY,Ashton-Rickardt PG

更新日期：2013-05-01 00:00:00

abstract：:Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties,...

journal_title：Biomaterials

authors： Walsh WR,Guzelsu N

更新日期：1994-01-01 00:00:00

abstract：:In spite of good prospects for bone morphogenetic proteins (BMP) applications, an ideal carrier system for BMPs has not yet been identified. The purpose of this study was to evaluate the osteogenic effect of a fibrin-fibronectin sealing system (FFSS) combined with beta-tricalcium phosphate (beta-TCP) as a carrier syst...

journal_title：Biomaterials

authors： Hong SJ,Kim CS,Han DK,Cho IH,Jung UW,Choi SH,Kim CK,Cho KS

更新日期：2006-07-01 00:00:00

abstract：:A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized polymers: PEI-HZ-DOX (PHD) an...

journal_title：Biomaterials

authors： Dong DW,Xiang B,Gao W,Yang ZZ,Li JQ,Qi XR

更新日期：2013-07-01 00:00:00

abstract：:Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod ...

journal_title：Biomaterials

authors： Jin L,Shen S,Huang Y,Li D,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Collagen fibers are essential components of tissues, which are highly conserved across the animal kingdom and could be extremely useful in tissue engineering. The formation of these macromolecular fibers depends on molecular interactions-based self-assembly of the basic building blocks of collagen called tropocollagen...

journal_title：Biomaterials

authors： Krishnamoorthy N,Yacoub MH,Yaliraki SN

更新日期：2011-10-01 00:00:00

abstract：:Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature to allow for targeted imaging. However, their inherent physical instability is an ongoing concern that could weaken their imaging ability with ultrasound. Gas vesicles (GVs), which are genetically encoded,...

journal_title：Biomaterials

authors： Wang G,Song L,Hou X,Kala S,Wong KF,Tang L,Dai Y,Sun L

更新日期：2020-04-01 00:00:00

abstract：:Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures have been developed in order to improve the efficiency and the specificity of drug action. Their small size permits them to be injected intravenously in order to reach target tissues. However, it is known that they can be rapidly...

journal_title：Biomaterials

authors： Vonarbourg A,Passirani C,Saulnier P,Benoit JP

更新日期：2006-08-01 00:00:00

abstract：:Titanium implants have been used widely and successfully for various types of bone-anchored reconstructions. It is believed that properties of oxide films covering titanium implant surfaces are of crucial importance for a successful osseointegration, in particular at compromized bone sites. The aim of the present stud...

journal_title：Biomaterials

authors： Sul YT,Johansson CB,Petronis S,Krozer A,Jeong Y,Wennerberg A,Albrektsson T

更新日期：2002-01-01 00:00:00

abstract：:Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...

journal_title：Biomaterials

authors： Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

更新日期：2012-05-01 00:00:00

abstract：:We determined whether a two-part space-conforming polyethylene glycol/dopa polymer-based gel promoted healing of contaminated wounds in mice. This silver-catalysed gel was previously developed to be broadly microbiocidal in vitro while being biocompatible with human wound cell functioning. Full-thickness wounds were c...

journal_title：Biomaterials

authors： Yates CC,Whaley D,Babu R,Zhang J,Krishna P,Beckman E,Pasculle AW,Wells A

更新日期：2007-09-01 00:00:00

abstract：:To study the effect of ionizable functional groups on the adhesion of leucocytes to surfaces, both poly(ethyleneimine) and poly(acrylic acid) were immobilized on polyurethane films, resulting in the introduction of amine and carboxylic acid groups, respectively. This was confirmed by contact angle measurements and XPS...

journal_title：Biomaterials

authors： Bruil A,Terlingen JG,Beugeling T,van Aken WG,Feijen J

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study was to investigate the chemical influence of chemo-mechanical caries removal (CMCR) on surface topography of dental ceramic materials. Thirty samples of three different types of ceramics (Vita Omega, Vita Alpha, and Procera AllTitan) were manufactured and used. With an optical profilometer, d...

journal_title：Biomaterials

authors： Arvidsson A,Milleding P,Wennerberg A

更新日期：2002-10-01 00:00:00

abstract：:The construction of tissue-engineered devices for medical applications is now possible in vitro using cell culture and bioreactors. Although methods of incorporating them back into the host are available, current constructs depend purely on diffusion which limits their potential. The absence of a vascular network capa...

journal_title：Biomaterials

authors： Kannan RY,Salacinski HJ,Sales K,Butler P,Seifalian AM

更新日期：2005-05-01 00:00:00

abstract：:Physiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using w...

journal_title：Biomaterials

authors： Malinen MM,Kanninen LK,Corlu A,Isoniemi HM,Lou YR,Yliperttula ML,Urtti AO

更新日期：2014-06-01 00:00:00

abstract：:Hydroxylated and methylated surfaces were prepared by the self-assembled monolayer technique (SAM) of alkane thiols on gold. The surfaces were used to evaluate the influence of implant surface chemistry on protein deposition and inflammatory cell response. Implants were inserted subcutaneously in the rat for 3 and 24 ...

journal_title：Biomaterials

authors： Källtorp M,Oblogina S,Jacobsson S,Karlsson A,Tengvall P,Thomsen P

更新日期：1999-11-01 00:00:00

abstract：:A major goal of bone tissue engineering is to design better scaffold configuration and materials to better control osteoblast behavior. Nanoporous architecture has been shown to significantly affect cellular response. In this work, nanoporous alumina membranes were fabricated by a two-step anodization method to invest...

journal_title：Biomaterials

authors： Popat KC,Leary Swan EE,Mukhatyar V,Chatvanichkul KI,Mor GK,Grimes CA,Desai TA

更新日期：2005-08-01 00:00:00

abstract：:The native retinal pigment epithelium (RPE) exists as a monolayer structure and is critically involved in the maintenance of photoreceptors. Damage or destruction of the RPE due to a variety of diseases therefore often results in loss of vision. With regenerative purposes in mind, we have examined various culture cond...

journal_title：Biomaterials

authors： Kubota A,Nishida K,Yamato M,Yang J,Kikuchi A,Okano T,Tano Y

更新日期：2006-07-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:In arterial replacement there is a clear clinical need for a functional substitute possessing appropriate haemocompatible properties to be implanted as small diameter artery. Endothelial cell seeding constitutes an appreciated method to improve blood compatibility on the condition that cells firmly adhere to the suppo...

journal_title：Biomaterials

authors： Rémy M,Durand M,Menu P,Voegel JC,Ponsot JF,Bérard X,Harmand MF,Bordenave L

更新日期：2013-12-01 00:00:00

abstract：:A simple approach to the mechanical modulation of layer-by-layer (LbL) films is through manipulation of the film assembly. Here, we report results based on altering the salt concentration during film assembly and its effect on film rigidity. Based on changes in film rigidity, cell adhesion characteristics and transfec...

journal_title：Biomaterials

authors： Blacklock J,Vetter A,Lankenau A,Oupický D,Möhwald H

更新日期：2010-09-01 00:00:00

abstract：:Patients with stable vitiligo can be helped surgically using transplantation of autologous cultured melanocytes, but there is a need for a culture methodology that is free from xenobiotic agents and for a simple way of delivering cultured melanocytes to the patient to achieve pigmentation with good wound healing. The ...

journal_title：Biomaterials

authors： Eves PC,Beck AJ,Shard AG,Mac Neil S

更新日期：2005-12-01 00:00:00

abstract：:After surgery, the bone and soft tissues around integrated biomaterials can be adversely affected by implant-related factors acting over a period of years. However, few studies have directly addressed the effects upon the adjacent soft tissue. The present study was designed to test the biological effects of various si...

journal_title：Biomaterials

authors： Sun JS,Tsuang YH,Chang WH,Li J,Liu HC,Lin FH

更新日期：1997-05-01 00:00:00

abstract：:Cell sheet technology has emerged as an important tissue engineering approach. Adipose-derived stem cells (ASCs) have valuable applications in regenerative medicine, but their stemness and differentiation capabilities in the cell sheet format have not been well investigated. In this study, we found that l-ascorbate 2-...

journal_title：Biomaterials

authors： Yu J,Tu YK,Tang YB,Cheng NC

更新日期：2014-04-01 00:00:00

abstract：:An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...

journal_title：Biomaterials

authors： Assal Y,Mie M,Kobatake E

更新日期：2013-04-01 00:00:00

abstract：:Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, prolifer...

journal_title：Biomaterials

authors： Wang X,Wei F,Liu A,Wang L,Wang JC,Ren L,Liu W,Tu Q,Li L,Wang J

更新日期：2012-05-01 00:00:00

abstract：:Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms are unknown. In order to investigate the role of 3D cell-cell interactions in maintaining hepatocyte differentiated functions ex vivo, primary mouse hepatocytes were ...

journal_title：Biomaterials

authors： Chang TT,Hughes-Fulford M

更新日期：2014-02-01 00:00:00