FRET-enabled biological characterization of polymeric micelles.

abstract：:Intracellular-acting therapeutic proteins offer a promising clinical alternative to extracellular-acting agents, but are limited in efficacy by their low permeability into the cell cytoplasm. We have developed a nanoparticle (NP) composed of lipid (DOTAP/DOPE) and apolipoprotein (APOA-I) to mediate the targeted delive...

journal_title：Biomaterials

authors： Kim SK,Foote MB,Huang L

更新日期：2012-05-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:Two types of cells--human platelets and spore cells--were encapsulated in polymer shells by adsorbing polyanions and polycations in a stepwise fashion. The encapsulated cells were attached to gold and silicon surfaces and their morphological and adhesion properties were studied in air using tapping mode atomic force m...

journal_title：Biomaterials

authors： Yu M,Ivanisevic A

更新日期：2004-08-01 00:00:00

abstract：:While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or lipid components. Her...

journal_title：Biomaterials

authors： Jackson MA,Bedingfield SK,Yu F,Stokan ME,Miles RE,Curvino EJ,Hoogenboezem EN,Bonami RH,Patel SS,Kendall PL,Giorgio TD,Duvall CL

更新日期：2019-02-01 00:00:00

abstract：:The management of trauma-associated nerve defects is difficult because of the absence of autologous donor motor or sensory nerves. Pre-clinical development and clinical experience has shown that damaged nerves can be surgically repaired using a tubular conduit interposed across the defect. Acceptable patient outcomes ...

journal_title：Biomaterials

authors： Sierpinski P,Garrett J,Ma J,Apel P,Klorig D,Smith T,Koman LA,Atala A,Van Dyke M

更新日期：2008-01-01 00:00:00

abstract：:Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential...

journal_title：Biomaterials

authors： Yin L,Song Z,Kim KH,Zheng N,Tang H,Lu H,Gabrielson N,Cheng J

更新日期：2013-03-01 00:00:00

abstract：:Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and size, and controlled release of immune-modulators. As thes...

journal_title：Biomaterials

authors： Kosmides AK,Meyer RA,Hickey JW,Aje K,Cheung KN,Green JJ,Schneck JP

更新日期：2017-02-01 00:00:00

abstract：:One of the major obstacles in drug discovery is the lack of in vitro three-dimensional (3D) models that can capture more complex features of a disease.Here we established a in vitro physiological model of the metabolic syndrome (MS) using cell-assembly technique (CAT), which can assemble cells into designated places t...

journal_title：Biomaterials

authors： Xu M,Wang X,Yan Y,Yao R,Ge Y

更新日期：2010-05-01 00:00:00

abstract：:Ferroptosis, a newfound non-apoptotic cell death pathway, results from the accumulation of iron-dependent lipid peroxide (LPO). Recently, emerging iron-based nanomaterials have been extensively developed to induce Fenton reaction-dependent ferroptosis for cancer therapy. However, insufficient amount of H2O2 and limite...

journal_title：Biomaterials

authors： He YJ,Liu XY,Xing L,Wan X,Chang X,Jiang HL

更新日期：2020-05-01 00:00:00

abstract：:While subcutaneous tissue has been proposed as a potential site for pancreatic islet transplantation, concern remains that the microvasculature of subcutaneous tissue is too poor to support transplanted islets. In an effort to overcome this limitation, we evaluated whether fibrin gel with human adipose-derived stem ce...

journal_title：Biomaterials

authors： Bhang SH,Jung MJ,Shin JY,La WG,Hwang YH,Kim MJ,Kim BS,Lee DY

更新日期：2013-10-01 00:00:00

abstract：:The in vivo performance of 250 retrieved internal fixation plates was evaluated. The corrosion characteristics and metallurgical properties of each implant were assessed and correlated with respective clinical performance. Screw-plate interface corrosion and screw surface corrosion were graded; Rockwell hardness, grai...

journal_title：Biomaterials

authors： Cook SD,Thomas KA,Harding AF,Collins CL,Haddad RJ Jr,Milicic M,Fischer WL

更新日期：1987-05-01 00:00:00

abstract：:Surface microroughness increases osteoblast differentiation and enhances responses of osteoblasts to 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. The observations that beta1 integrin expression is increased in osteoblasts grown on Ti substrates with rough microarchitecture, and that it is regulated by 1alpha,25(OH)2D3...

journal_title：Biomaterials

authors： Wang L,Zhao G,Olivares-Navarrete R,Bell BF,Wieland M,Cochran DL,Schwartz Z,Boyan BD

更新日期：2006-07-01 00:00:00

abstract：:In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogel...

journal_title：Biomaterials

authors： Karadağ E,Saraydin D,Cetinkaya S,Güven O

更新日期：1996-01-01 00:00:00

abstract：:A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized polymers: PEI-HZ-DOX (PHD) an...

journal_title：Biomaterials

authors： Dong DW,Xiang B,Gao W,Yang ZZ,Li JQ,Qi XR

更新日期：2013-07-01 00:00:00

abstract：:Titanium and its alloys are widely used in load-bearing implants as a result of their excellent mechanical properties and corrosion resistance. In order to improve their performances with respect to osseointegration, the use of bioactive coatings has been suggested. Polypyrrole (PPy) has been chosen as coating polymer...

journal_title：Biomaterials

authors： De Giglio E,Guascito MR,Sabbatin L,Zambonin G

更新日期：2001-10-01 00:00:00

abstract：:Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

journal_title：Biomaterials

authors： Kim MH,Kino-oka M

更新日期：2014-07-01 00:00:00

abstract：:Cell-extracellular cell matrix (ECM) interactions play a vital role in development including cytoskeletal structure, growth and differentiation. A 15 amino acid, non-RGD containing, peptide that is derived from type I collagen was tested for its ability to confer cell survival. Two routinely utilized bone graft materi...

journal_title：Biomaterials

authors： Hanks T,Atkinson BL

更新日期：2004-08-01 00:00:00

abstract：:A study on the evolution with age of the mineral composition of bones was performed on samples belonging to human and other common mammalian species (cattle, sheep, dog). The study was carried out on the ashes obtained by calcination of the bone samples (1 h at 900 degrees C). The calcined powders were carefully exami...

journal_title：Biomaterials

authors： Ravaglioli A,Krajewski A,Celotti GC,Piancastelli A,Bacchini B,Montanari L,Zama G,Piombi L

更新日期：1996-03-01 00:00:00

abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...

journal_title：Biomaterials

authors： Dandamudi S,Campbell RB

更新日期：2007-11-01 00:00:00

abstract：:Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hy...

journal_title：Biomaterials

authors： Azuma K,Nishihara M,Shimizu H,Itoh Y,Takashima O,Osaki T,Itoh N,Imagawa T,Murahata Y,Tsuka T,Izawa H,Ifuku S,Minami S,Saimoto H,Okamoto Y,Morimoto M

更新日期：2015-02-01 00:00:00

abstract：:Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neopla...

journal_title：Biomaterials

authors： Doran A,Law FC,Allen MJ,Rushton N

更新日期：1998-04-01 00:00:00

abstract：:Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts o...

journal_title：Biomaterials

authors： Nguyen KT,West JL

更新日期：2002-11-01 00:00:00

abstract：:Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical complexity of articular cartilage is through the use of recombinant bacterial collagens...

journal_title：Biomaterials

authors： Parmar PA,Skaalure SC,Chow LW,St-Pierre JP,Stoichevska V,Peng YY,Werkmeister JA,Ramshaw JA,Stevens MM

更新日期：2016-08-01 00:00:00

abstract：:In the traditional Chinese medicine, Gu-Sui-Bu [Drynaria fortunei (kunze) J. Sm] has been reported as a good enhancer for bone healing. In this experiment, we investigate the biochemical effects of this traditional Chinese medicine on the bone cells culture. Different concentrations of crude extract of Gu-Sui-Bu were ...

journal_title：Biomaterials

authors： Sun JS,Lin CY,Dong GC,Sheu SY,Lin FH,Chen LT,Wang YJ

更新日期：2002-08-01 00:00:00

abstract：:Topographic features can modulate cell behaviours such as proliferation, migration, differentiation and apoptosis. Biochemical mechanotransduction implies the conversion of mechanical forces (e.g. changes in cell spreading and morphology from changing surface topography) into biochemical signal via biomolecules. Still...

journal_title：Biomaterials

authors： Kantawong F,Burgess KE,Jayawardena K,Hart A,Burchmore RJ,Gadegaard N,Oreffo RO,Dalby MJ

更新日期：2009-09-01 00:00:00

abstract：:As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

journal_title：Biomaterials

authors： England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

更新日期：2016-09-01 00:00:00

abstract：:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants...

journal_title：Biomaterials

authors： Yang Y,Qiao X,Huang R,Chen H,Shi X,Wang J,Tan W,Tan Z

更新日期：2020-02-01 00:00:00

abstract：:We previously reported that modification of GALA peptide on the surface of liposomes enhanced fusion with endosomal membrane, and cytoplasmic release of encapsulated macromolecules. We report herein that an additional coating of GALA-modified liposomes with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer result...

journal_title：Biomaterials

authors： Ukawa M,Akita H,Masuda T,Hayashi Y,Konno T,Ishihara K,Harashima H

更新日期：2010-08-01 00:00:00

abstract：:Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem™, a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vas...

journal_title：Biomaterials

authors： Aurora A,Roe JL,Corona BT,Walters TJ

更新日期：2015-10-01 00:00:00

abstract：:Bone morphogenetic protein-2/absorbable collagen sponge (BMP-2/ACS) implants have been approved for clinical use to induce bone regeneration. We previously showed that exaggerated inflammation characterized by elevated level of inflammatory cytokines including TNF-α, IL-1β, and IL-6 has been shown to inhibit BMP-2/ACS...

journal_title：Biomaterials

authors： Huang RL,Chen G,Wang W,Herller T,Xie Y,Gu B,Li Q

更新日期：2015-10-01 00:00:00