In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels.

Abstract:

:In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are incubated in 10 different human sera for 24 h and their biocompatibilities with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide/crotonic and acrylamide/itaconic acid hydrogels are biocompatible.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Karadağ E,Saraydin D,Cetinkaya S,Güven O

doi

10.1016/0142-9612(96)80757-5

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

67-70

issue

1

eissn

0142-9612

issn

1878-5905

pii

0142961296807575

journal_volume

17

pub_type

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