Regional biomechanical and histological characterisation of the passive porcine urinary bladder: Implications for augmentation and tissue engineering strategies.

abstract：:Polydimethylsiloxanes exhibit hydrophobic behaviour and poor wettability. These features impose some problems with the clinical performance of the material when used for the construction of intraoral and extraoral facial prostheses. Surface active agents were added to modify the surface energy of the polydimethylsilox...

journal_title：Biomaterials

authors： Polyzois GL,Winter RW,Stafford GD

更新日期：1991-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are generally induced to differentiate by forming spherical structures termed embryoid bodies (EBs) in the presence of soluble growth factors. hEBs are generated by suspending small clumps of hESC colonies; however, the resulting hEBs are heterogeneous because this method lacks the a...

journal_title：Biomaterials

authors： Moon SH,Ju J,Park SJ,Bae D,Chung HM,Lee SH

更新日期：2014-07-01 00:00:00

abstract：:Seven nominally identical samples of Na-free carbonate apatite (CO(3)Ap) were prepared by reaction of CaHPO(4) with ammonium carbonate solution at 70 degrees C over 3 days. They were studied by chemical analysis, Rietveld analysis of powder X-ray diffraction (XRD) data, Ca/P ratio determinations (quantitative phase an...

journal_title：Biomaterials

authors： Wilson RM,Dowker SE,Elliott JC

更新日期：2006-09-01 00:00:00

abstract：:Cytoxicity is an essential concern for polyethyleneimine 25 kDa (PEI 25 kDa), a widely reported, highly effective transfection agent used in gene delivery. In our recent experiments, Small molecular weight cross-linked poly(ethylene imine) by biscarbamate linkage (PEI-Bu) (Mn: 3278, Mw: 4289) can reduce target cell ap...

journal_title：Biomaterials

authors： Xiang S,Su J,Tong H,Yang F,Tong W,Yuan W,Wu F,Wang C,Jin T,Dai K,Zhang X

更新日期：2012-09-01 00:00:00

abstract：:Non-viral carriers for gene therapy have been developed to minimize carrier cytotoxicity and to enhance transfection efficiency. Previously, we synthesized a 9-arginine-based reducible high molecular weight peptide for gene delivery. For the reducible poly(oligo-D-arginines) (rPOA), 9-arginine oligopeptides are connec...

journal_title：Biomaterials

authors： Hyun H,Won YW,Kim KM,Lee J,Lee M,Kim YH

更新日期：2010-12-01 00:00:00

abstract：:Topical therapy is the most favored form of treatment for whitening against hyperpigmentation and sunburn because it lends itself to self-administration, patient compliance, and absence of systemic adverse effects. However, transdermal delivery of hydrophilic chemicals is difficult. The main purpose of this study is t...

journal_title：Biomaterials

authors： Candan G,Michiue H,Ishikawa S,Fujimura A,Hayashi K,Uneda A,Mori A,Ohmori I,Nishiki T,Matsui H,Tomizawa K

更新日期：2012-09-01 00:00:00

abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

journal_title：Biomaterials

authors： Kendall MA,Chong YF,Cock A

更新日期：2007-11-01 00:00:00

abstract：:A pH-sensitive molecularly imprinted polymer (MIP) nanospheres/hydrogel composite exhibiting controlled release of dexamethasone-21 phosphate disodium (DXP) was developed as a potential coating for implantable biosensors to improve their biocompatibility. The molecularly imprinted pH-sensitive nanospheres were prepare...

journal_title：Biomaterials

authors： Wang C,Javadi A,Ghaffari M,Gong S

更新日期：2010-06-01 00:00:00

abstract：:Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency of these islets is limited by host immune responses. Extensive efforts have been made to immunoisolate these islets by introducing barriers on the islet surface. To date, these ba...

journal_title：Biomaterials

authors： Izadi Z,Hajizadeh-Saffar E,Hadjati J,Habibi-Anbouhi M,Ghanian MH,Sadeghi-Abandansari H,Ashtiani MK,Samsonchi Z,Raoufi M,Moazenchi M,Izadi M,Nejad ASSH,Namdari H,Tahamtani Y,Ostad SN,Akbari-Javar H,Baharvand H

更新日期：2018-11-01 00:00:00

abstract：:Tissue engineering of clinical-relevant large tissue constructs remains a big challenge due to the mass transfer limit. A modular approach via the assembling of modular tissues thus eliminating the mass transfer limit holds great promise for fabricating centimeter-sized constructs. In the present study, we investigate...

journal_title：Biomaterials

authors： Chen M,Wang X,Ye Z,Zhang Y,Zhou Y,Tan WS

更新日期：2011-10-01 00:00:00

abstract：:Recently, chitosan-gelatin scaffolds have gained much attention in various tissue engineering applications. However, the underlying cell-matrix interactions remain unclear in addition to the scaffold degradation and mechanical characteristics. In this study, we evaluated (i) the degradation kinetics of chitosan and ch...

journal_title：Biomaterials

authors： Huang Y,Onyeri S,Siewe M,Moshfeghian A,Madihally SV

更新日期：2005-12-01 00:00:00

abstract：:Immobilization of biomolecules on surfaces enables both localization and retention of molecules at the cell-biomaterial interface. Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, biomolecular modification of these materials is challenging. In the pre...

journal_title：Biomaterials

authors： Puleo DA,Kissling RA,Sheu MS

更新日期：2002-05-01 00:00:00

abstract：:Microstructure of thermal sprayed hydroxyapatite (HA) splats was characterized using transmission electron microscopy (TEM), and the formation mechanisms of micropores within the splats were investigated with the aid of simulated body fluids (SBF). High-velocity oxy-fuel and direct current (DC) plasma spray techniques...

journal_title：Biomaterials

authors： Li H,Khor KA,Cheang P

更新日期：2004-08-01 00:00:00

abstract：:A rapid and simple in vitro method is described which measures the extent of unrecoiled solids compression when a complex biopolymer is subjected to a centrifugal force. This method, termed the compaction assay, was used to assess the response of purulent cystic fibrosis (CF) sputum samples to the addition of recombin...

journal_title：Biomaterials

authors： Daugherty AL,Patapoff TW,Clark RC,Sinicropi DV,Mrsny RJ

更新日期：1995-05-01 00:00:00

abstract：:A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (perfluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafio...

journal_title：Biomaterials

authors： Gopalan AI,Lee KP,Ragupathy D,Lee SH,Lee JW

更新日期：2009-10-01 00:00:00

abstract：:Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently aga...

journal_title：Biomaterials

authors： Shao L,Li Q,Zhao C,Lu J,Li X,Chen L,Deng X,Ge G,Wu Y

更新日期：2019-02-01 00:00:00

abstract：:Docetaxel (DOC) produces anti-tumor effects by inducing apoptosis and inhibiting cell growth. However, its clinical application is limited by its hydrophobicity and low biocompatibility. Therefore, improving DOC's water solubility, biocompatibility, and anti-tumor effects are important goals that will improve its clin...

journal_title：Biomaterials

authors： Gao X,Wang S,Wang B,Deng S,Liu X,Zhang X,Luo L,Fan R,Xiang M,You C,Wei Y,Qian Z,Guo G

更新日期：2015-01-01 00:00:00

abstract：:When subjected to a monotonically increasing deformation state, the mechanical behavior of UHMWPE is characterized by a linear elastic response followed by distributed yielding and strain hardening at large deformations. During the unloading phases of an applied cyclic deformation process, the response is characterize...

journal_title：Biomaterials

authors： Bergström JS,Kurtz SM,Rimnac CM,Edidin AA

更新日期：2002-06-01 00:00:00

abstract：:Nanomedicine options for colon cancer therapy have been limited by the lack of suitable carriers capable of delivering sufficient drug into tumors to cause lethal toxicity. To circumvent this limitation, we fabricated a camptothecin (CPT)-loaded poly(lactic-co-glycolic acid) nanoparticle (NP) with dual-surface functio...

journal_title：Biomaterials

authors： Xiao B,Zhang M,Viennois E,Zhang Y,Wei N,Baker MT,Jung Y,Merlin D

更新日期：2015-04-01 00:00:00

abstract：:Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections...

journal_title：Biomaterials

authors： Huang N,Chen X,Zhu X,Xu M,Liu J

更新日期：2017-10-01 00:00:00

abstract：:The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-proc...

journal_title：Biomaterials

authors： Qian Y,Jin H,Qiao S,Dai Y,Huang C,Lu L,Luo Q,Zhang Z

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to characterize a nasally delivered bioadhesive liposome using an inactivated H5N3 virus as a model antigen. Bioadhesive liposomes were developed using tremella (T) or xanthan gum (XG) as the bioadhesive polysaccharide. Using chickens as the target animal, we evaluated whether delivery of a b...

journal_title：Biomaterials

authors： Chiou CJ,Tseng LP,Deng MC,Jiang PR,Tasi SL,Chung TW,Huang YY,Liu DZ

更新日期：2009-10-01 00:00:00

abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

journal_title：Biomaterials

authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

更新日期：2020-02-01 00:00:00

abstract：:Keratins are a family of structural proteins that can be isolated from a variety of tissues. "Soft" keratins are cytoskeletal elements found in epithelial tissues while protective tissues such as nails, hooves, and hair are composed of "hard" keratins. Hard keratins have been the subject of biomaterials investigations...

journal_title：Biomaterials

authors： Hill P,Brantley H,Van Dyke M

更新日期：2010-02-01 00:00:00

abstract：:Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread cells. Additionally, the system facilitates immuno-fluorescent staining of aspirated cells to investi...

journal_title：Biomaterials

authors： Reynolds NH,Ronan W,Dowling EP,Owens P,McMeeking RM,McGarry JP

更新日期：2014-04-01 00:00:00

abstract：:Overcoming biological barriers to imaging-guided site-specific delivery of therapeutics is the goal of current nanomedicine designs. Here, multifunctional polymer-coated carbon nanodots with an interleukin-6 (IL-6) fragment peptide for receptor-targeting (pCDPI) were prepared for drug delivery. The pCDPI exhibits smal...

journal_title：Biomaterials

authors： Wang S,Li C,Qian M,Jiang H,Shi W,Chen J,Lächelt U,Wagner E,Lu W,Wang Y,Huang R

更新日期：2017-10-01 00:00:00

abstract：:Peripheral nerve injuries often lead to incomplete recovery and contribute to significant disability to approximately 360,000 people in the USA each year. Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and differentiation potential in vivo are stil...

journal_title：Biomaterials

authors： Du J,Zhen G,Chen H,Zhang S,Qing L,Yang X,Lee G,Mao HQ,Jia X

更新日期：2018-10-01 00:00:00

abstract：:Site specific targeting remains elusive for gene and stem cell therapies in the cardiovascular field. One promising option involves use of devices that deliver larger and more sustained cell/gene payloads to specific disease sites using the versatility of percutaneous vascular access technology. Smooth muscle cells (S...

journal_title：Biomaterials

authors： Kumar AH,Martin K,Doyle B,Huang CL,Pillai GK,Ali MT,Skelding KA,Wang S,Gleeson BM,Jahangeer S,Ritman EL,Russell SJ,Caplice NM

更新日期：2014-10-01 00:00:00

abstract：:A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...

journal_title：Biomaterials

authors： Zeng S,Xiong MP

更新日期：2013-09-01 00:00:00

abstract：:The differences in morphological behaviour between fibroblasts cultured on smooth and nanogrooved substrata (groove depth: 5-350 nm, width: 20-1000 nm) have been evaluated in vitro. The aim of the study was to clarify to what extent cell guidance occurs on increasingly smaller topographies. Pattern templates were made...

journal_title：Biomaterials

authors： Loesberg WA,te Riet J,van Delft FC,Schön P,Figdor CG,Speller S,van Loon JJ,Walboomers XF,Jansen JA

更新日期：2007-09-01 00:00:00