Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1).

abstract：:A quantitative comparison between nuclear DNA release from carriers and their transfection activity would be highly useful for improving the effectiveness of non-viral gene vectors. We previously reported that, for condensed DNA particles, a close relationship exists between the efficiency of DNA release and transfect...

journal_title：Biomaterials

authors： Yamada Y,Nomura T,Harashima H,Yamashita A,Yui N

更新日期：2012-05-01 00:00:00

abstract：:This study was designed to explore the feasibility of using cartilage-derived morphogenetic protein-1 (CDMP1) induced dermal fibroblasts (DFs) as seed cells and polyglycolide (PGA) as scaffold for fibrocartilage engineering. DFs isolated from canine were expanded and seeded on PGA scaffold to fabricate cell/scaffold c...

journal_title：Biomaterials

authors： Zhao G,Yin S,Liu G,Cen L,Sun J,Zhou H,Liu W,Cui L,Cao Y

更新日期：2009-07-01 00:00:00

abstract：:Distearoylphophatidylcholine (DSPC) mixed with various mole percentages of polyethylene oxide (number average molecular weight 2000)-grafted distearoylphosphatidylethanolamine (PEO2000-DSPE) were deposited on DSPE-coated quartz surfaces by the Langmuir-Blodgett deposition. Structural transitions in PEO2000 from pancak...

journal_title：Biomaterials

authors： Xu Z,Marchant RE

更新日期：2000-05-01 00:00:00

abstract：:This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...

journal_title：Biomaterials

authors： Hayashi K,Mashima T,Uenoyama K

更新日期：1999-01-01 00:00:00

abstract：:Both positively and negatively charged residues play pivotal roles in recruiting precursor ions or ion clusters, and lowering interfacial energy in natural biomineralization process. Synergistic utilization of opposite charges, however, has rarely been implemented in the design of cytocompatible synthetic scaffolds pr...

journal_title：Biomaterials

authors： Liu P,Song J

更新日期：2013-03-01 00:00:00

abstract：:Mesenchymal condensation is a pre-requisite of chondrogenesis during embryonic development. The current understanding of chondrogenesis is limited in terms of chondrogenic condensation mechanisms. In particular, the role of matrix stiffness on homotypic cell-cell interactions leading to the establishment of distinct a...

journal_title：Biomaterials

authors： Ghosh S,Laha M,Mondal S,Sengupta S,Kaplan DL

更新日期：2009-11-01 00:00:00

abstract：:Random copolymers of trimethylene carbonate and epsilon-caprolactone have been synthesized through ring-opening polymerization using rare earth alkoxides as initiator. The structure of the copolymers has been characterized by 1H and 13C NMR. Their thermal behaviour, their permeability to liquid and their mechanical pr...

journal_title：Biomaterials

authors： Schappacher M,Fabre T,Mingotaud AF,Soum A

更新日期：2001-11-01 00:00:00

abstract：:Patients regularly taking non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (IND) have a risk of small intestinal injuries. In this study, we have developed an oral nanotherapeutics by using a redox nanoparticle (RNP(O)), which is prepared by self-assembly of an amphiphilic block copolymer that posse...

journal_title：Biomaterials

authors： Sha S,Vong LB,Chonpathompikunlert P,Yoshitomi T,Matsui H,Nagasaki Y

更新日期：2013-11-01 00:00:00

abstract：:This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on t...

journal_title：Biomaterials

authors： Gristina AG,Hobgood CD,Webb LX,Myrvik QN

更新日期：1987-11-01 00:00:00

abstract：:Islet-like cells derived from embryonic stem (ES) cells may be a promising therapeutic option for future diabetes treatment. Here, we demonstrated a five-stage protocol with adding exendin-4 instead of nicotinamide finally could generate islet-like cells from human embryonic stem (ES) cells. Immunofluorescence analysi...

journal_title：Biomaterials

authors： Mao GH,Chen GA,Bai HY,Song TR,Wang YX

更新日期：2009-03-01 00:00:00

abstract：:Here, we demonstrated dimethyldioctadecylammonium bromide (DODAB), a cationic lipid, bilayer coated Au nanoparticles (AuNPs) could efficiently deliver two types of plasmid DNA into human embryonic kidney cells (HEK 293) in the presence of serum. The transfection efficiency of AuNPs was about five times higher than tha...

journal_title：Biomaterials

authors： Li P,Li D,Zhang L,Li G,Wang E

更新日期：2008-09-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are effective in scavenging intracellular reactive oxygen species (ROS). In this study nanoceria synthesized by flame spray pyrolysis (dXRD = 12 nm) were functionalised with heparin via an organosilane linker, 3-aminopropyltriethoxysilane. Nanoceria were functionalised with appro...

journal_title：Biomaterials

authors： Ting SR,Whitelock JM,Tomic R,Gunawan C,Teoh WY,Amal R,Lord MS

更新日期：2013-06-01 00:00:00

abstract：:We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also se...

journal_title：Biomaterials

authors： Khoo X,Simons EJ,Chiang HH,Hickey JM,Sabharwal V,Pelton SI,Rosowski JJ,Langer R,Kohane DS

更新日期：2013-01-01 00:00:00

abstract：:X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2O3 (BP/Bi2O3) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer ...

journal_title：Biomaterials

authors： Huang H,He L,Zhou W,Qu G,Wang J,Yang N,Gao J,Chen T,Chu PK,Yu XF

更新日期：2018-07-01 00:00:00

abstract：:A two-layer hydroxyapatite (HA)/HA+TiO(2) bond coat composite coating (HTH coating) on titanium was fabricated by plasma spraying. The HA+TiO(2) bond coat (HTBC) consists of 50 vol% HA and 50 vol% TiO(2) (HT). The microstructural characterization of the HTH coatings before and after heat treatment was conducted by usi...

journal_title：Biomaterials

authors： Lu YP,Li MS,Li ST,Wang ZG,Zhu RF

更新日期：2004-08-01 00:00:00

abstract：:Three-dimensional constructs formed by cells embedded in an exogenous scaffold could not represent a faithful in vitro replica of native and functional tissues. In this work we produced an endogenous human skin equivalent by means of a tissue engineering process that induces the full morphogenesis of functional dermal...

journal_title：Biomaterials

authors： Casale C,Imparato G,Urciuolo F,Netti PA

更新日期：2016-09-01 00:00:00

abstract：:Osteomyelitis characterized by an inflammatory response often leads to bone loss and the spread of bacterial infection to surrounding soft tissues. To overcome the side effects induced by the systemic antibiotic treatment for osteomyelitis, recent investigations have explored the use of antibiotic-loaded undegradable ...

journal_title：Biomaterials

authors： Peng KT,Chen CF,Chu IM,Li YM,Hsu WH,Hsu RW,Chang PJ

更新日期：2010-07-01 00:00:00

abstract：:The objective of this study was to investigate the effect of repeated applications of a neutral NaF solution on the surface roughness of four conventional glass ionomer cements (GIC) (ChemFil Superior encapsulated, Fuji Cap II, Ketac-Fil and Hi Dense), three resin-modified (RM-) GIC (Fuji II LC encapsulated, Photac-Fi...

journal_title：Biomaterials

authors： De Witte AM,De Maeyer EA,Verbeeck RM

更新日期：2003-05-01 00:00:00

abstract：:The present study deals with the effect of the type and chemical character of incorporated polyester (polyether blocks) on the hydrolytic stability of different types of polyurethane medical adhesive dressings. Diffusion parameters of the investigated polyurethane adhesives, giving information concerning the chemical ...

journal_title：Biomaterials

authors： Pavlova M,Draganova M

更新日期：1994-01-01 00:00:00

abstract：:We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 microm dependin...

journal_title：Biomaterials

authors： Ferreira L,Gil MH,Cabrita AM,Dordick JS

更新日期：2005-08-01 00:00:00

abstract：:Development of biochips containing living cells for biodetection, drug screening and tissue engineering applications is limited by a lack of reconfigurable material interfaces and actuators. Here we describe a new class of nanostructured magnetizable materials created with a femtosecond laser surface etching technique...

journal_title：Biomaterials

authors： Polte TR,Shen M,Karavitis J,Montoya M,Pendse J,Xia S,Mazur E,Ingber DE

更新日期：2007-06-01 00:00:00

abstract：:The creep strain rate and fracture of several dental amalgams has been shown to be markedly dependent on the type of loading applied. Cyclic loading typical of the in vivo situation increases creep rates and reduces times to fracture when analysis is based on a Mechanical Equation of State. The cyclic strain rate enha...

journal_title：Biomaterials

authors： Williams KR

更新日期：1983-10-01 00:00:00

abstract：:Polyelectrolyte complexes (PEC) were prepared from chitosan as the polycation and several synthesized functional anion polysaccharides, and their effects on cell attachment, morphology, proliferation and differentiation were estimated using normal human osteoblasts (NHOst). After a 1-week incubation, PEC made from pol...

journal_title：Biomaterials

authors： Nagahata M,Nakaoka R,Teramoto A,Abe K,Tsuchiya T

更新日期：2005-09-01 00:00:00

abstract：:Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biol...

journal_title：Biomaterials

authors： Verron E,Gauthier O,Janvier P,Pilet P,Lesoeur J,Bujoli B,Guicheux J,Bouler JM

更新日期：2010-10-01 00:00:00

abstract：:Poly(3, 4-ethylenedioxythiophene)-coated carbon microfibers (PEDOT-MFs) hold promise for developing advanced neuroprostheses and neural repair devices. We investigated the chronic cellular responses to PEDOT-MFs implanted into the uninjured and the transected rat spinal cord, and compared the effects of polymer surfac...

journal_title：Biomaterials

authors： Alves-Sampaio A,García-Rama C,Collazos-Castro JE

更新日期：2016-05-01 00:00:00

abstract：:The main challenge for neural progenitor cell (NPC)-mediated repair of spinal cord injury (SCI) is lack of favorable environment to direct its differentiation towards neurons rather than glial cells. The myelin associated inhibitors have been demonstrated to promote NPC differentiation into glial lineage. Herein, to i...

journal_title：Biomaterials

authors： Li X,Xiao Z,Han J,Chen L,Xiao H,Ma F,Hou X,Li X,Sun J,Ding W,Zhao Y,Chen B,Dai J

更新日期：2013-07-01 00:00:00

abstract：:Saturated neoglycopolymers, prepared via tandem ROMP-hydrogenation (ROMP=ring-opening metathesis polymerization) of carbohydrate-functionalized norbornenes, are investigated as novel collagen crosslinking agents in corneal tissue engineering. The neoglycopolymers were incorporated into recombinant human collagen type ...

journal_title：Biomaterials

authors： Merrett K,Liu W,Mitra D,Camm KD,McLaughlin CR,Liu Y,Watsky MA,Li F,Griffith M,Fogg DE

更新日期：2009-10-01 00:00:00

abstract：:Bioencapsulation involves the envelopment of tissues or biological active substances in semipermeable membranes. Bioencapsulation has been shown to be efficacious in mimicking the cell's natural environment and thereby improves the efficiency of production of different metabolites and therapeutic agents. The field of ...

journal_title：Biomaterials

authors： de Vos P,Bucko M,Gemeiner P,Navrátil M,Svitel J,Faas M,Strand BL,Skjak-Braek G,Morch YA,Vikartovská A,Lacík I,Kolláriková G,Orive G,Poncelet D,Pedraz JL,Ansorge-Schumacher MB

更新日期：2009-05-01 00:00:00

abstract：:Neural transplantation therapy using neural stem cells has received as potential treatments for neurodegenerative diseases. Indeed, this therapy is thought to be effective for replacement of degenerating neurons in restricted anatomical region. However, because injected neural stem cells integrate randomly into the ho...

journal_title：Biomaterials

authors： Kato-Negishi M,Tsuda Y,Onoe H,Takeuchi S

更新日期：2010-12-01 00:00:00

abstract：:Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fib...

journal_title：Biomaterials

authors： Wintermantel E,Mayer J,Blum J,Eckert KL,Lüscher P,Mathey M

更新日期：1996-01-01 00:00:00