Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures.

abstract：:Novel cationic pentablock copolymers with poly(diethylamino ethyl methacrylate) blocks covalently attached to parent triblock Pluronic copolymers have been designed and developed as sustained release non-viral gene delivery vectors. These copolymers electrostatically condense plasmid DNA into nanostructures (nanoplexe...

journal_title：Biomaterials

authors： Agarwal A,Unfer RC,Mallapragada SK

更新日期：2008-02-01 00:00:00

abstract：:Unlike silkworm and spider silks assembled from very large and repetitive fibrous proteins, the bee and ant silks were recently demonstrated to consist of four small and non-repetitive coiled-coil proteins. The design principle for this silk family remains largely unknown and so far no structural study is available on...

journal_title：Biomaterials

authors： Shi J,Lua S,Du N,Liu X,Song J

更新日期：2008-06-01 00:00:00

abstract：:Liver tissue engineering requires a perfect extracellular matrix (ECM) for primary hepatocytes culture to maintain high level of liver-specific functions and desirable mechanical stability. The aim of this study was to develop a novel natural nanofibrous scaffold with surface-galactose ligands to enhance the bioactivi...

journal_title：Biomaterials

authors： Feng ZQ,Chu X,Huang NP,Wang T,Wang Y,Shi X,Ding Y,Gu ZZ

更新日期：2009-05-01 00:00:00

abstract：:pH-triggered lipid-membranes designed from biophysical principles are evaluated in the form of targeted liposomal doxorubicin with the aim to ultimately better control the growth of vascularized tumors. We compare the antitumor efficacy of anti-HER2/neu pH-triggered lipid vesicles encapsulating doxorubicin to the anti...

journal_title：Biomaterials

authors： Bandekar A,Karve S,Chang MY,Mu Q,Rotolo J,Sofou S

更新日期：2012-06-01 00:00:00

abstract：:Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our limited understanding and control of the interactions within complex in...

journal_title：Biomaterials

authors： D'Hollander A,Jans H,Velde GV,Verstraete C,Massa S,Devoogdt N,Stakenborg T,Muyldermans S,Lagae L,Himmelreich U

更新日期：2017-04-01 00:00:00

abstract：:In an effort to examine liver injury, immune response, and other physiological effects in mice caused by intragastric administration of nanoparticulate anatase titanium dioxide (5nm), we assessed T lymphocytes, B lymphocyte and NK lymphocyte counts, hematological indices, biochemical parameters of liver functions, and...

journal_title：Biomaterials

authors： Duan Y,Liu J,Ma L,Li N,Liu H,Wang J,Zheng L,Liu C,Wang X,Zhao X,Yan J,Wang S,Wang H,Zhang X,Hong F

更新日期：2010-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosens...

journal_title：Biomaterials

authors： Lin LJ,Grimme JM,Sun J,Lu S,Gai L,Cropek DM,Wang Y

更新日期：2013-05-01 00:00:00

abstract：:The aim of this in vitro study was to investigate the effect of low-level laser therapy (LLLT) on the attachment, proliferation, differentiation and production of transforming growth factor-ss(1) (TGF-beta(1)) by human osteoblast-like cells (HOB). Cells derived from human mandibular bone were exposed to GaAlAs diode l...

journal_title：Biomaterials

authors： Khadra M,Lyngstadaas SP,Haanaes HR,Mustafa K

更新日期：2005-06-01 00:00:00

abstract：:Bioactive glass granules were implanted in the tibiae of rabbits in order to determine the pathway of the silicon released from bioactive glass in vivo. We traced and quantified the silicon released by obtaining 24-h urine samples and blood samples for up to 7 months after implantation. Bone tissue as well as the foll...

journal_title：Biomaterials

authors： Lai W,Garino J,Ducheyne P

更新日期：2002-01-01 00:00:00

abstract：:Hydrogels are commonly used as artificial extracellular matrices for 3D cell culture and for tissue engineering. Viscoelastic hydrogels with tunable stress relaxation have recently been developed, and stress relaxation in the hydrogels has been found to play a key role in regulating cell behaviors such as differentiat...

journal_title：Biomaterials

authors： Nam S,Stowers R,Lou J,Xia Y,Chaudhuri O

更新日期：2019-04-01 00:00:00

abstract：:Multilayered coatings composed of mixtures of HA and P2O5-based bioactive glasses are of potential clinical benefit in orthopaedic and dental surgery. Pre-immersion of these materials has been reported to further enhance their efficacy in vivo, although the precise biological effects of this treatment are not yet know...

journal_title：Biomaterials

authors： Ferraz MP,Knowles JC,Olsen I,Monteiro FJ,Santos JD

更新日期：2000-04-01 00:00:00

abstract：:This is the first report on a series of studies of the crystallinity of bone tissues. The measurements were done at the microfocused diffraction beamline at ERSF (European Synchrotron Radiation Facility) as a feasibility test on various aspects on microdiffraction analysis. Beside the crystal structure, crystallite si...

journal_title：Biomaterials

authors： Rindby A,Voglis P,Engström P

更新日期：1998-11-01 00:00:00

abstract：:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...

journal_title：Biomaterials

authors： Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

更新日期：2020-09-01 00:00:00

abstract：:Developing materials that are effective against sexually transmitted pathogens such as Chlamydia trachomatis (Ct) and HIV-1 is challenging both in terms of material selection and improving bio-membrane and cellular permeability at desired mucosal sites. Here, we engineered the prokaryotic bacterial virus (M13 phage) c...

journal_title：Biomaterials

authors： Bhattarai SR,Yoo SY,Lee SW,Dean D

更新日期：2012-07-01 00:00:00

abstract：:Biomaterials can potentially influence stem and progenitor cell proliferation and differentiation in both a positive and a negative way. Herein, we report on the expansion and differentiation of rat embryonic (E17) liver (RLC-18) cells on new bioactive membrane made of PEEK-WC-PU, whose surface was grafted with nitrog...

journal_title：Biomaterials

authors： Pavlica S,Piscioneri A,Peinemann F,Keller M,Milosevic J,Staeudte A,Heilmann A,Schulz-Siegmund M,Laera S,Favia P,De Bartolo L,Bader A

更新日期：2009-11-01 00:00:00

abstract：:The present work assesses the potential of three-dimensional porous titanium scaffolds produced by a novel powder metallurgy process for applications in bone engineering through in vitro experimentation. Mouse MC3T3-E1 pre-osteoblasts were used to investigate the proliferation (DNA content), differentiation (alkaline ...

journal_title：Biomaterials

authors： St-Pierre JP,Gauthier M,Lefebvre LP,Tabrizian M

更新日期：2005-12-01 00:00:00

abstract：:Hydrogels have been widely used as artificial cell niche to mimic extracellular matrix with tunable properties. However, changing biochemical cues in hydrogels developed-to-date would often induce simultaneous changes in mechanical properties, which do not support mechanistic studies on stem cell-niche interactions. H...

journal_title：Biomaterials

authors： Tong X,Yang F

更新日期：2014-02-01 00:00:00

abstract：:Previously we demonstrated the ability of ethyl glycinato substituted polyphosphazenes to neutralize the acidic degradation products and control the degradation rate of poly(lactic acid-glycolic acid) (PLAGA) by blending. In this study, blends of high strength poly[(50% ethyl alanato) (50% p-phenyl phenoxy) phosphazen...

journal_title：Biomaterials

authors： Deng M,Nair LS,Nukavarapu SP,Kumbar SG,Jiang T,Krogman NR,Singh A,Allcock HR,Laurencin CT

更新日期：2008-01-01 00:00:00

abstract：:It is well known that biomaterials play an important role in the regulation of adhesion and growth of a variety of cultured cell types. However, whether biomaterials are associated with the senescence of cultured cells is not known. The present work shows that the decrease of the hydrophobic property of poly (ethylene...

journal_title：Biomaterials

authors： Lou PJ,Chiu MY,Chou CC,Liao BW,Young TH

更新日期：2010-03-01 00:00:00

abstract：:The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode. The friction force and adhesive force measurements were able to differentiate the non-crosslinked pHEMA chains from the surface of the crosslinked pHEMA n...

journal_title：Biomaterials

authors： Kim SH,Marmo C,Somorjai GA

更新日期：2001-12-01 00:00:00

abstract：:TRAIL has received considerable attention as a potential anti-cancer agent due to its specific ability to target tumors. However, recombinant TRAIL has several limitations, such as, its short biological half-life, its inherent instability, and its potential hepatotoxicity. In this study, we developed a sustained relea...

journal_title：Biomaterials

authors： Lim SM,Kim TH,Jiang HH,Park CW,Lee S,Chen X,Lee KC

更新日期：2011-05-01 00:00:00

abstract：:Characterization of complex adsorbed protein films is a critical aspect of biomaterials science, particularly in understanding the in vivo response to biomaterials. The surface analysis techniques electron spectroscopy for chemical analysis (ESCA) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are parti...

journal_title：Biomaterials

authors： Wagner MS,Horbett TA,Castner DG

更新日期：2003-05-01 00:00:00

abstract：:To maintain enzymatic activity during long-term storage by conjugation with water-soluble 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers (PMPC-COOH) having various molecular weights with a carboxylic group on the terminal, such compounds were synthesized as a polymer modifier using a photoinduced living radic...

journal_title：Biomaterials

authors： Miyamoto D,Watanabe J,Ishihara K

更新日期：2004-01-01 00:00:00

abstract：:Specifically inhibiting the proliferation of activated macrophages and clearing the high levels of reactive oxygen species (ROS) secreted by macrophages is crucial for osteoarthritis (OA) treatment. Moreover, if the clearance of these high levels of ROS can be simultaneously used to induce oxidation-responsive release...

journal_title：Biomaterials

authors： Yang G,Fan M,Zhu J,Ling C,Wu L,Zhang X,Zhang M,Li J,Yao Q,Gu Z,Cai X

更新日期：2020-10-01 00:00:00

abstract：:The limited intrinsic repair capacity of articular cartilage has stimulated continuing efforts to develop tissue engineered analogues. Matrices composed of type II collagen and chondroitin sulfate (CS), the major constituents of hyaline cartilage, may create an appropriate environment for the generation of cartilage-l...

journal_title：Biomaterials

authors： Pieper JS,van der Kraan PM,Hafmans T,Kamp J,Buma P,van Susante JL,van den Berg WB,Veerkamp JH,van Kuppevelt TH

更新日期：2002-08-01 00:00:00

abstract：:A method to fabricate porous, biodegradable conduits using a combined injection molding, thermally induced phase transition technique was developed which produced conduits with dimensionally toleranced, longitudinally aligned channels. The geometry of the channels was designed to approximate the architecture of periph...

journal_title：Biomaterials

authors： Sundback C,Hadlock T,Cheney M,Vacanti J

更新日期：2003-02-01 00:00:00

abstract：:This study aimed to investigate certain processes of fluoride production which enable glass ionomer cements to leach fluoride. Two fluoroaluminosilicate glasses, G338 and LG26 were used. The free and total fluoride which could be dissolved from the glasses was measured, before and after acetic acid washing. Both glass...

journal_title：Biomaterials

authors： Williams JA,Billington RW,Pearson GJ

更新日期：2002-05-01 00:00:00

abstract：:Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

journal_title：Biomaterials

authors： Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

更新日期：2015-10-01 00:00:00

abstract：:The in vivo evaluation, in New Zealand rabbits, of a SiO(2)-P(2)O(5)-CaO sol-gel glass and a SiO(2)-P(2)O(5)-CaO-MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5mm in diameter and 4mm in depth, wer...

journal_title：Biomaterials

authors： Gil-Albarova J,Garrido-Lahiguera R,Salinas AJ,Román J,Bueno-Lozano AL,Gil-Albarova R,Vallet-Regí M

更新日期：2004-08-01 00:00:00

abstract：:The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in three-dimensions (3D). A facile method was developed to modify gelatin with cysteine via a bifunctional PEG linker, thus intr...

journal_title：Biomaterials

authors： Fu Y,Xu K,Zheng X,Giacomin AJ,Mix AW,Kao WJ

更新日期：2012-01-01 00:00:00