Abstract：
:We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 microm depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Ferreira L,Gil MH,Cabrita AM,Dordick JSdoi
10.1016/j.biomaterials.2004.11.051keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
4707-16issue
23eissn
0142-9612issn
1878-5905pii
S0142-9612(04)01055-5journal_volume
26pub_type
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