Abstract:
:Degradable hydrogels to deliver bioactive proteins represent an emerging platform for promoting tissue repair and vascularization in various applications. However, implanting these biomaterials requires invasive surgery, which is associated with complications such as inflammation, scarring, and infection. To address these shortcomings, we applied microfluidics-based polymerization to engineer injectable poly(ethylene glycol) microgels of defined size and crosslinked with a protease degradable peptide to allow for triggered release of proteins. The release rate of proteins covalently tethered within the microgel network was tuned by modifying the ratio of degradable to non-degradable crosslinkers, and the released proteins retained full bioactivity. Microgels injected into the dorsum of mice were maintained in the subcutaneous space and degraded within 2 weeks in response to local proteases. Furthermore, controlled release of VEGF from degradable microgels promoted increased vascularization compared to empty microgels or bolus injection of VEGF. Collectively, this study motivates the use of microgels as a viable method for controlled protein delivery in regenerative medicine applications.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Foster GA,Headen DM,González-García C,Salmerón-Sánchez M,Shirwan H,García AJdoi
10.1016/j.biomaterials.2016.10.044subject
Has Abstractpub_date
2017-01-01 00:00:00pages
170-175eissn
0142-9612issn
1878-5905pii
S0142-9612(16)30595-6journal_volume
113pub_type
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