Abstract:
:This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-401). Crystallisation during biodegradation was not considered in the previous work which is the topic of the current paper. For many commonly used biodegradable polymers, there is a strong interplay between crystallisation and hydrolysis reaction during biodegradation - the chain cleavage caused by the hydrolysis reaction provides an extra mobility for the polymer chains to crystallise and the resulting crystalline phase becomes more resistant to further hydrolysis reaction. This paper presents a complete theory to describe this interplay. The fundamental equations in the Avrami's theory for crystallisation are modified and coupled to the diffusion-reaction equations that were developed in our previous work. The mathematical equations are then applied to three biodegradable polymers for which long term degradation data are available in the literature. It is shown that the model can capture the behavior of the major biodegradable polymers very well.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Han X,Pan Jdoi
10.1016/j.biomaterials.2008.10.001subject
Has Abstractpub_date
2009-01-01 00:00:00pages
423-30issue
3eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00742-4journal_volume
30pub_type
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