当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential.

Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential.

Abstract：

:Combinations of calcium phosphate scaffolds and bioactive factors are promising niche-mimetic solutions for repairing large-sized bone defects. However, the importance of compatibility between scaffolds and bioactive factors on their osteogenic outcomes has been largely ignored. This study aimed to investigate the compatibility of calcinated antler cancellous bone (CACB) scaffolds with various bioactive factors including icariin (ICA), velvet antler polypeptides (VAP) or recombinant human bone morphogenetic protein-2 (rhBMP-2) as well as their combinational osteogenic potential in vitro and in vivo. Scanning electron microscopy and fourier transform infrared spectroscopy confirmed the uniform distribution and chemical stability of the reagents on CABC. In vitro release profiles showed relative steady release of ICA from ICA/CACB, burst VAP release from VAP/CACB, and minimal rhBMP-2 release from rhBMP-2/CACB composites. When compared with VAP and rhBMP-2, incorporation of ICA within CACB resulted in most increased cell attachment, proliferation, alkaline phosphatase activity, osteogenic gene expression, and mineralization of rat bone marrow mesenchymal stem cells. In rabbit mandible critical-sized defects, the most extensive osteogenesis and neovascularization were observed in the ICA/CACB group. Differences between the VAP/CACB and rhBMP-2/CACB groups were not apparent. Interestingly, low pro-inflammatory (TNF-α, IL-6) and high anti-inflammatory (IL-10) mRNA levels were observed at scaffold implantation sites which were in close association with amount of new bone formation. These findings highlight that the compatibility between scaffolds and bioactive factors should been taken into account when considering the formula of optimized bone defect repair.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Zhang X,Xu M,Song L,Wei Y,Lin Y,Liu W,Heng BC,Peng H,Wang Y,Deng X

doi

10.1016/j.biomaterials.2013.08.024

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

9103-14

issue

36

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(13)00972-1

journal_volume

34

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Biofunctionalized PEDOT-coated microfibers for the treatment of spinal cord injury.

    abstract：:Poly(3, 4-ethylenedioxythiophene)-coated carbon microfibers (PEDOT-MFs) hold promise for developing advanced neuroprostheses and neural repair devices. We investigated the chronic cellular responses to PEDOT-MFs implanted into the uninjured and the transected rat spinal cord, and compared the effects of polymer surfac...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.02.037

    authors： Alves-Sampaio A,García-Rama C,Collazos-Castro JE

    更新日期：2016-05-01 00:00:00

  • The effect of keratinocytes on the biomechanical characteristics and pore microstructure of tissue engineered skin using deep dermal fibroblasts.

    abstract：:Fibrosis affects most organs, it results in replacement of normal parenchymal tissue with collagen-rich extracellular matrix, which compromises tissue architecture and ultimately causes loss of function of the affected organ. Biochemical pathways that contribute to fibrosis have been extensively studied, but the role ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.07.048

    authors： Varkey M,Ding J,Tredget EE,Wound Healing Research Group.

    更新日期：2014-12-01 00:00:00

  • Bioactivation of an anorganic bone matrix by P-15 peptide for the promotion of early bone formation.

    abstract：:This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2005.02.023

    authors： Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

    更新日期：2005-10-01 00:00:00

  • Scaffold vascularization in vivo driven by primary human osteoblasts in concert with host inflammatory cells.

    abstract：:Successful cell-based tissue engineering requires a rapid and thorough vascularization in order to ensure long-term implant survival and tissue integration. The vascularization of a scaffold is a complex process, and is modulated by the presence of transplanted cells, exogenous and endogenous signaling proteins, and t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.07.041

    authors： Ghanaati S,Unger RE,Webber MJ,Barbeck M,Orth C,Kirkpatrick JA,Booms P,Motta A,Migliaresi C,Sader RA,Kirkpatrick CJ

    更新日期：2011-11-01 00:00:00

  • Synthesis and application of strawberry-like Fe3O4-Au nanoparticles as CT-MR dual-modality contrast agents in accurate detection of the progressive liver disease.

    abstract：:Development of non-invasive assay for the accurate diagnosis of progressive liver diseases (e.g., fatty liver and hepatocellular carcinoma (HCC)) is of great clinical significance and remains to be a big challenge. Herein, we reported the synthesis of strawberry-like Fe3O4-Au hybrid nanoparticles at room temperature t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.02.019

    authors： Zhao HY,Liu S,He J,Pan CC,Li H,Zhou ZY,Ding Y,Huo D,Hu Y

    更新日期：2015-05-01 00:00:00

  • Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching.

    abstract：:Although dendritic nanoparticles have been prepared by many different methods, control over their degree of branching (DB) is still impossible, preventing us from understanding the effect of the DB on the properties of the nanodendrites as cancer therapeutics. Herein, we developed a novel seed-mediated method to prepa...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.06.033

    authors： Qiu P,Yang M,Qu X,Huai Y,Zhu Y,Mao C

    更新日期：2016-10-01 00:00:00

  • Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells.

    abstract：:Sodium alginate hydrogel, stabilized with gelatin, is a suitable, biologically inert matrix that can be used for encapsulating and 3D bioprinting of bone-related SaOS-2 cells. However, the cells, embedded in this matrix, remain in a non-proliferating state. Here we show that addition of an overlay onto the bioprinted ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.07.002

    authors： Neufurth M,Wang X,Schröder HC,Feng Q,Diehl-Seifert B,Ziebart T,Steffen R,Wang S,Müller WEG

    更新日期：2014-10-01 00:00:00

  • The promotion of osteoblastic differentiation of rat bone marrow stromal cells by a polyvalent plant mosaic virus.

    abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.06.029

    authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

    更新日期：2008-10-01 00:00:00

  • The effect of a fibrin-fibronectin/beta-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects.

    abstract：:In spite of good prospects for bone morphogenetic proteins (BMP) applications, an ideal carrier system for BMPs has not yet been identified. The purpose of this study was to evaluate the osteogenic effect of a fibrin-fibronectin sealing system (FFSS) combined with beta-tricalcium phosphate (beta-TCP) as a carrier syst...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.02.045

    authors： Hong SJ,Kim CS,Han DK,Cho IH,Jung UW,Choi SH,Kim CK,Cho KS

    更新日期：2006-07-01 00:00:00

  • Development of in situ thermosensitive drug vehicles for glaucoma therapy.

    abstract：:The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. Thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced polymeric eyedrop con...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00035-8

    authors： Hsiue GH,Chang RW,Wang CH,Lee SH

    更新日期：2003-06-01 00:00:00

  • The performance of a hydrogel nucleus pulposus prosthesis in an ex vivo canine model.

    abstract：:A nucleus pulposus prosthesis (NPP) made of the hydrogel N-vinyl-2-pyrrolidinone copolymerized with 2-(4'-iodobenzoyl)-oxo-ethyl methacrylate has recently been developed. The special features of this NPP, i.e. intrinsic radiopacity and its ability to swell in situ to fill the nucleus cavity and restore disc height, we...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.05.032

    authors： Bergknut N,Smolders LA,Koole LH,Voorhout G,Hagman RE,Lagerstedt AS,Saralidze K,Hazewinkel HA,van der Veen AJ,Meij BP

    更新日期：2010-09-01 00:00:00

  • Proliferation and differentiation of adipose-derived stem cells on naturally derived scaffolds.

    abstract：:A tissue-engineered substitute that facilitates large-volume regeneration of the subcutaneous adipose tissue layer is needed for reconstructive plastic surgery. Towards this goal, we describe the in vitro culture of primary human adipose-derived stem cells (ASC) seeded into placental decellular matrix (PDM) and cross-...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2007.12.028

    authors： Flynn LE,Prestwich GD,Semple JL,Woodhouse KA

    更新日期：2008-04-01 00:00:00

  • The effect of micropores in the surface of temperature-responsive culture inserts on the fabrication of transplantable canine oral mucosal epithelial cell sheets.

    abstract：:Primary canine oral mucosal epithelial cells were cultured on temperature-responsive dishes and cell culture inserts to fabricate transplantable epithelial cell sheets. When 3T3 feeder layers and fetal bovine serum were eliminated from dish culture, the harvested cell sheets became significantly more fragile. In contr...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.05.042

    authors： Murakami D,Yamato M,Nishida K,Ohki T,Takagi R,Yang J,Namiki H,Okano T

    更新日期：2006-11-01 00:00:00

  • In vitro model of mesenchymal condensation during chondrogenic development.

    abstract：:Mesenchymal condensation is a pre-requisite of chondrogenesis during embryonic development. The current understanding of chondrogenesis is limited in terms of chondrogenic condensation mechanisms. In particular, the role of matrix stiffness on homotypic cell-cell interactions leading to the establishment of distinct a...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.08.019

    authors： Ghosh S,Laha M,Mondal S,Sengupta S,Kaplan DL

    更新日期：2009-11-01 00:00:00

  • The effect of controlled release of PDGF-BB from heparin-conjugated electrospun PCL/gelatin scaffolds on cellular bioactivity and infiltration.

    abstract：:Heparin-conjugated electrospun poly(ε-caprolactone) (PCL)/gelatin scaffolds were developed to provide controlled release of platelet-derived growth factor-BB (PDGF-BB) and allow prolonged bioactivity of this molecule. A mixture of PCL and gelatin was electrospun into three different morphologies. Next, heparin molecul...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.06.017

    authors： Lee J,Yoo JJ,Atala A,Lee SJ

    更新日期：2012-10-01 00:00:00

  • Surface-modified GVs as nanosized contrast agents for molecular ultrasound imaging of tumor.

    abstract：:Nanobubbles, as a kind of new ultrasound contrast agent (UCAs), have shown promise to penetrate tumor vasculature to allow for targeted imaging. However, their inherent physical instability is an ongoing concern that could weaken their imaging ability with ultrasound. Gas vesicles (GVs), which are genetically encoded,...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.119803

    authors： Wang G,Song L,Hou X,Kala S,Wong KF,Tang L,Dai Y,Sun L

    更新日期：2020-04-01 00:00:00

  • Porous methacrylate scaffolds: supercritical fluid fabrication and in vitro chondrocyte responses.

    abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.10.023

    authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

    更新日期：2004-08-01 00:00:00

  • Chemical and physical properties of a hydrogel wound dressing.

    abstract：:Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(86)90092-x

    authors： Kickhöfen B,Wokalek H,Scheel D,Ruh H

    更新日期：1986-01-01 00:00:00

  • Importance of hydroxyapatite particles characteristics on cytokines production by human monocytes in vitro.

    abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00089-9

    authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

    更新日期：2003-07-01 00:00:00

  • The artificial disc: theory, design and materials.

    abstract：:Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: d...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/0142-9612(96)84936-2

    authors： Bao QB,McCullen GM,Higham PA,Dumbleton JH,Yuan HA

    更新日期：1996-06-01 00:00:00

  • Investigation of Ti/Al2O3 joints with intermediate tantalum and niobium layers.

    abstract：:The microstructure of TiTa30 alloys diffusion bonded to a 99.7 wt% Al2O3 ceramic was subdivided into a reaction double layer containing the intermetallic phases TiAl and Ti3Al and the (alpha + beta) Ti microstructure. Excellent fracture toughness data of the TiTa30/Al2O3 joints of about 37 J/m2 were obtained after wel...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(92)90166-l

    authors： Gibbesch B,Elssner G,Petzow G

    更新日期：1992-01-01 00:00:00

  • Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles.

    abstract：:TRAIL has received considerable attention as a potential anti-cancer agent due to its specific ability to target tumors. However, recombinant TRAIL has several limitations, such as, its short biological half-life, its inherent instability, and its potential hepatotoxicity. In this study, we developed a sustained relea...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.01.054

    authors： Lim SM,Kim TH,Jiang HH,Park CW,Lee S,Chen X,Lee KC

    更新日期：2011-05-01 00:00:00

  • Molecular basis of osteoclastogenesis induced by osteoblasts exposed to wear particles.

    abstract：:In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al(2)O(3)) or 'ultra-high molecular weight polyethylene' (UHMWPE) particles for 24h. T...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.07.045

    authors： Granchi D,Amato I,Battistelli L,Ciapetti G,Pagani S,Avnet S,Baldini N,Giunti A

    更新日期：2005-05-01 00:00:00

  • The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells.

    abstract：:Particle-based vaccine delivery systems are under exploration to enhance antigen-specific immunity against safe but poorly immunogenic polypeptide antigens. Chitosan is a promising biomaterial for antigen encapsulation and delivery due to its ability to form nano- and microparticles in mild aqueous conditions thus pre...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.11.066

    authors： Koppolu B,Zaharoff DA

    更新日期：2013-03-01 00:00:00

  • Gel spinning of silk tubes for tissue engineering.

    abstract：:Tubular vessels for tissue engineering are typically fabricated using a molding, dipping, or electrospinning technique. While these techniques provide some control over inner and outer diameters of the tube, they lack the ability to align the polymers or fibers of interest throughout the tube. This is an important asp...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.08.025

    authors： Lovett ML,Cannizzaro CM,Vunjak-Novakovic G,Kaplan DL

    更新日期：2008-12-01 00:00:00

  • Microwave CO2 plasma-initiated vapour phase graft polymerization of acrylic acid onto polytetrafluoroethylene for immobilization of human thrombomodulin.

    abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00045-8

    authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

    更新日期：1997-09-01 00:00:00

  • Synthesis and characterization of a new vertebroplasty cement based on gold-containing PMMA microspheres.

    abstract：:There are a number of drawbacks to incorporating large concentrations of barium sulfate (BaSO4) as the radiopacifier in PMMA-based bone cements for percutaneous vertebroplasty. These include adverse effects on injectability, viscosity profile, setting time, mechanical properties of the cement and bone resorption. We h...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.12.024

    authors： Jacobs E,Saralidze K,Roth AK,de Jong JJ,van den Bergh JP,Lataster A,Brans BT,Knetsch ML,Djordjevic I,Willems PC,Koole LH

    更新日期：2016-03-01 00:00:00

  • Self-assembling polystyrene-block-poly(ethylene oxide) copolymer surface coatings: resistance to protein and cell adhesion.

    abstract：:In this paper we report a method for biomaterial surface modification that utilizes the self-assembly of block copolymers of poly(styrene-block-ethylene oxide) (PS-PEO) to generate micro-phase separated surfaces with varying density PEO domains. These PS-PEO self-assembled surfaces showed a significant reduction in pr...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.01.012

    authors： George PA,Donose BC,Cooper-White JJ

    更新日期：2009-05-01 00:00:00

  • Analysis of MRI images of a silicone elastomer under different axial loading conditions.

    abstract：:Silicone elastomers have been used as implants in orthopaedics for replacements of small joints such as the metacarpophalangeal joint. A series of experiments was conducted an axially tensioned silicone elastomer tendon spacer samples to determine whether there is a relationship between stress in the material and imag...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00155-5

    authors： Abel EW,Wheeler KI,Chudek JA,Hunter G,Som FM

    更新日期：1998-01-01 00:00:00

  • Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel.

    abstract：:A system of nanoparticles of mixed lipid monolayer shell and biodegradable polymer core was developed for targeted delivery of anticancer drugs with Docetaxel as a model drug, which provide targeting versatility with a quantitative control of the targeting effect by adjusting the lipid component ratio of the mixed lip...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.09.036

    authors： Liu Y,Li K,Pan J,Liu B,Feng SS

    更新日期：2010-01-01 00:00:00