Abstract：
:There are a number of drawbacks to incorporating large concentrations of barium sulfate (BaSO4) as the radiopacifier in PMMA-based bone cements for percutaneous vertebroplasty. These include adverse effects on injectability, viscosity profile, setting time, mechanical properties of the cement and bone resorption. We have synthesized a novel cement that is designed to address some of these drawbacks. Its powder includes PMMA microspheres in which gold particles are embedded and its monomer is the same as that used in commercial cements for vertebroplasty. In comparison to one such commercial cement brand, VertaPlex™, the new cement has longer doughing time, longer injection time, higher compressive strength, higher compressive modulus, and is superior in terms of cytotoxicity. For augmentation of fractured fresh-frozen cadaveric vertebral bodies (T6-L5) using simulated vertebroplasty, results for compressive strength and compressive stiffness of the construct and the percentage of the volume of the vertebral body filled by the cement were comparable for the two cements although the radiopacity of the new cement was significantly lower than that for VertaPlex™. The present results indicate that the new cement warrants further study.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Jacobs E,Saralidze K,Roth AK,de Jong JJ,van den Bergh JP,Lataster A,Brans BT,Knetsch ML,Djordjevic I,Willems PC,Koole LHdoi
10.1016/j.biomaterials.2015.12.024subject
Has Abstractpub_date
2016-03-01 00:00:00pages
60-70eissn
0142-9612issn
1878-5905pii
S0142-9612(15)01012-1journal_volume
82pub_type
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