Abstract:
:A new approach to overcome the degradation of protein drugs by proteolytic enzymes and their targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of drugs into the polymeric hydrogel containing glycoprotein--ovomucoid from duck egg whites. This glycoprotein inhibits the activity of proteolytic enzymes and acts as a biospecific ligand to lectins on the walls of the gastrointestinal tract.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Plate NA,Valuev IL,Sytov GA,Valuev LIdoi
10.1016/s0142-9612(01)00294-0keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
1673-7issue
7eissn
0142-9612issn
1878-5905pii
S0142961201002940journal_volume
23pub_type
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