Design and evaluation of polypseudorotaxanes of pegylated insulin with cyclodextrins as sustained release system.

abstract：:A new diamond ATR FTIR method has been developed to quantify the processes occurring in the resin-modified glass-ionomer cement (RMGIC). Fuji II LC (Improved), at 1 mm depth from the cement/water interface. With Fuji II LC (Improved) various changes in the spectra due to 90% monomer polymerisation were observed within...

journal_title：Biomaterials

authors： Young AM

更新日期：2002-08-01 00:00:00

abstract：:The regeneration of large bone defects remains an unsolved clinical problem, which could benefit from recent findings on the biology of skeletal stem and progenitor cells. The elucidation of conditions to specifically control their dynamic and function will likely enable the development of novel treatment strategies. ...

journal_title：Biomaterials

authors： Papageorgiou P,Vallmajo-Martin Q,Kisielow M,Sancho-Puchades A,Kleiner E,Ehrbar M

更新日期：2019-10-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:An urgent unmet need exists for early-stage treatment of spinal cord injury (SCI). Currently methylprednisolone is the only therapeutic agent used in clinics, for which the efficacy is controversial and the side effect is well-known. We demonstrated functional restoration of injured spinal cord by self-assembled nanop...

journal_title：Biomaterials

authors： Wu W,Lee SY,Wu X,Tyler JY,Wang H,Ouyang Z,Park K,Xu XM,Cheng JX

更新日期：2014-02-01 00:00:00

abstract：:CD47, a "don't eat me" signal, is over-expressed on the surface of most tumors that interacts with signal regulatory protein α (SIRPα) on phagocytic cells. By engaging SIRPα, CD47 limits the ability of macrophages to engulf tumor cells, which acts as a major phagocytic barrier. In this study, we developed an exosome-b...

journal_title：Biomaterials

authors： Koh E,Lee EJ,Nam GH,Hong Y,Cho E,Yang Y,Kim IS

更新日期：2017-03-01 00:00:00

abstract：:Over the past two decades, in vitro autologous endothelial cell (EC) coverage of expanded polytetrafluoroethylene (ePTFE) graft has been developed and clinically applied with success in infrainguinal bypasses. Before endothelialization, the luminal surface of the graft has to be coated with a currently used fibrinolyt...

journal_title：Biomaterials

authors： Fernandez P,Deguette A,Pothuaud L,Belleannée G,Coste P,Bordenave L

更新日期：2005-08-01 00:00:00

abstract：:Bioglass 45S5 is a silica-based melt-derived glass, used in medical field as a bone regenerative material because of the deposition of a layer of hydroxy carbonate apatite (HCA) on the surface of the glass when immersed in body fluid. The present paper studies the early steps of reaction of 2-microm sized particles of...

journal_title：Biomaterials

authors： Cerruti M,Greenspan D,Powers K

更新日期：2005-05-01 00:00:00

abstract：:The blood-brain barrier (BBB) prevents entry of neurotoxic substances but also that of drugs into the brain. Here, the paracellular barrier is formed by tight junctions (TJs) with claudin-5 (Cldn5) being the main sealing constituent. Transient BBB opening by targeting Cldn5 could improve paracellular drug delivery. Th...

journal_title：Biomaterials

authors： Neuhaus W,Piontek A,Protze J,Eichner M,Mahringer A,Subileau EA,Lee IM,Schulzke JD,Krause G,Piontek J

更新日期：2018-04-01 00:00:00

abstract：:A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phos...

journal_title：Biomaterials

authors： Ibim SE,Ambrosio AM,Kwon MS,El-Amin SF,Allcock HR,Laurencin CT

更新日期：1997-12-01 00:00:00

abstract：:We have used a new synthetic injectable composite constituted of hydroxyapatite/tricalcium phosphate (HA/TCP) particles in suspension in a self-hardening Si-hydroxypropylmethylcellulose (HPMC) hydrogel. The aim of this study was to evaluate in vivo the biocompatibility and the new bone formation efficacy of this scaff...

journal_title：Biomaterials

authors： Trojani C,Boukhechba F,Scimeca JC,Vandenbos F,Michiels JF,Daculsi G,Boileau P,Weiss P,Carle GF,Rochet N

更新日期：2006-06-01 00:00:00

abstract：:This study was designed to develop a skin permeable recombinant low-molecular-weight protamine (LMWP) conjugated epidermal growth factor (EGF) (rLMWP-EGF) by linking a highly positive charged LMWP to the N-terminal of EGF through genetic recombination. We evaluated its biological activity, skin permeability, and wound...

journal_title：Biomaterials

authors： Choi JK,Jang JH,Jang WH,Kim J,Bae IH,Bae J,Park YH,Kim BJ,Lim KM,Park JW

更新日期：2012-11-01 00:00:00

abstract：:The purpose of the present work was to examine the effect of different Ti-6Al-4V surface treatments on osteoblasts behaviour. Previous work in this laboratory has demonstrated that an ageing treatment reduces metal ion release from this alloy compared to standard passivation procedures. In this study. human osteosarco...

journal_title：Biomaterials

authors： Ku CH,Pioletti DP,Browne M,Gregson PJ

更新日期：2002-03-01 00:00:00

abstract：:We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT) peptide bypass the efflux action of P-glycoprotein and increase the transport of the encapsulated ritonavir, a protease inhibitor (PI), across the blood-brain-barrier (BBB) to the central nervous system (CNS). A steady increase in...

journal_title：Biomaterials

authors： Rao KS,Reddy MK,Horning JL,Labhasetwar V

更新日期：2008-11-01 00:00:00

abstract：:Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, a departure from legacy crosslinking chemistries was sought as a multipurpose platform for tissue mending. A fresh approach to bonding wet substrates has yielded a synthetic biomaterial that overcomes the drawbacks of free-r...

journal_title：Biomaterials

authors： Djordjevic I,Pokholenko O,Shah AH,Wicaksono G,Blancafort L,Hanna JV,Page SJ,Nanda HS,Ong CB,Chung SR,Chin AYH,McGrouther D,Choudhury MM,Li F,Teo JS,Lee LS,Steele TWJ

更新日期：2020-11-01 00:00:00

abstract：:A simple route for synthesizing nano-sized beta-tricalcium phosphate (beta-TCP) at room temperature has been developed in methanol solvent. The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging ...

journal_title：Biomaterials

authors： Bow JS,Liou SC,Chen SY

更新日期：2004-07-01 00:00:00

abstract：:The channel of the viral DNA packaging motor allows dsDNA to enter the protein procapsid shell during maturation and to exit during infection. We recently showed that the bacteriophage phi29 DNA packaging motor exercises a one-way traffic property using a channel as a valve for dsDNA translocation. This raises a quest...

journal_title：Biomaterials

authors： Geng J,Fang H,Haque F,Zhang L,Guo P

更新日期：2011-11-01 00:00:00

abstract：:Nanomedicine options for colon cancer therapy have been limited by the lack of suitable carriers capable of delivering sufficient drug into tumors to cause lethal toxicity. To circumvent this limitation, we fabricated a camptothecin (CPT)-loaded poly(lactic-co-glycolic acid) nanoparticle (NP) with dual-surface functio...

journal_title：Biomaterials

authors： Xiao B,Zhang M,Viennois E,Zhang Y,Wei N,Baker MT,Jung Y,Merlin D

更新日期：2015-04-01 00:00:00

abstract：:A major role of respiratory mucus is to trap inhaled particles, including pathogens and environmental particulates, to limit body exposure. Despite the tremendous health implications, how particle size and surface chemistry affect mobility in respiratory mucus from humans without lung disease is not known. We prepared...

journal_title：Biomaterials

authors： Schuster BS,Suk JS,Woodworth GF,Hanes J

更新日期：2013-04-01 00:00:00

abstract：:The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

journal_title：Biomaterials

authors： Wang X,Ma J,Feng Q,Cui F

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to develop a hydrogel which would be suitable for corneal cell re-epithelialization when used as a corneal implant. To achieve this, a series of hydrogels were functionalized with primary amines by post-polymerization reactions between amine compounds and glycidyl ether groups attached to the...

journal_title：Biomaterials

authors： Rimmer S,Johnson C,Zhao B,Collier J,Gilmore L,Sabnis S,Wyman P,Sammon C,Fullwood NJ,MacNeil S

更新日期：2007-12-01 00:00:00

abstract：:The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

journal_title：Biomaterials

authors： Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

更新日期：2012-06-01 00:00:00

abstract：:Developing materials that are effective against sexually transmitted pathogens such as Chlamydia trachomatis (Ct) and HIV-1 is challenging both in terms of material selection and improving bio-membrane and cellular permeability at desired mucosal sites. Here, we engineered the prokaryotic bacterial virus (M13 phage) c...

journal_title：Biomaterials

authors： Bhattarai SR,Yoo SY,Lee SW,Dean D

更新日期：2012-07-01 00:00:00

abstract：:Subtle changes on the surface of polymeric materials on autoclaving have been ignored so far. An increase in cyclic trimer content on the surface of polyethylene terephthalate on autoclaving is reported. This increase may affect the biocompatibility of polyethylene terephthalate. Quantification of the cyclic trimer wa...

journal_title：Biomaterials

authors： Nair PD,Sreenivasan K

更新日期：1984-09-01 00:00:00

abstract：:We design a class of imprinted hybrid microgels that can optically monitor glucose levels with high sensitivity and selectivity in complex media at physiological pH, acting like a "glucose-indicator". Such imprinted hybrid microgels were made of Ag nanoparticles (NPs) in situ immobilized in molecularly imprinted gluco...

journal_title：Biomaterials

authors： Wu W,Shen J,Li Y,Zhu H,Banerjee P,Zhou S

更新日期：2012-10-01 00:00:00

abstract：:Cell movement on adhesive surfaces is a complicated process based on myriad cell-surface interactions. Although both micron and nanoscale surface topography have been known to be important in understanding cell-materials interactions, typically only simple patterns (e.g., parallel lines or aligned posts) have been use...

journal_title：Biomaterials

authors： Jeon H,Hidai H,Hwang DJ,Healy KE,Grigoropoulos CP

更新日期：2010-05-01 00:00:00

abstract：:Nanoparticle-induced endothelial cell (EC) dysfunction, due to the induction of inflammation and/or the activation of the coagulation system, is associated with pulmonary and ischemic cardiovascular diseases. Although it is contigent on several mechanisms, involving formation of reactive oxygen species and inflammator...

journal_title：Biomaterials

authors： Bauer AT,Strozyk EA,Gorzelanny C,Westerhausen C,Desch A,Schneider MF,Schneider SW

更新日期：2011-11-01 00:00:00

abstract：:Two kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method. One (Lac-f-micelles: lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(l-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)...

journal_title：Biomaterials

authors： Ma P,Liu S,Huang Y,Chen X,Zhang L,Jing X

更新日期：2010-03-01 00:00:00

abstract：:In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modif...

journal_title：Biomaterials

authors： Yli-Urpo H,Närhi M,Närhi T

更新日期：2005-10-01 00:00:00

abstract：:Cartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human bone marrow (hBM) stem cells under hypoxic environment and delineated the mechanism whereby chondrogenesis could be condu...

journal_title：Biomaterials

authors： Duval E,Baugé C,Andriamanalijaona R,Bénateau H,Leclercq S,Dutoit S,Poulain L,Galéra P,Boumédiene K

更新日期：2012-09-01 00:00:00

abstract：:Implanted materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body reaction (FBR), which causes several complications for example in hip prostheses, silicone implants, peritoneal dialysis catheters and left ventricular assist devices. FBR is initiated by macr...

journal_title：Biomaterials

authors： Vranken I,De Visscher G,Lebacq A,Verbeken E,Flameng W

更新日期：2008-03-01 00:00:00